Inhibition of the TRPM4 channel by 9-PH attenuates hippocampal endothelial injury induced by sleep deprivation and the subsequent neuroinflammation and neurological dysfunction [0.03%]
9-PH抑制TRPM4通道减轻睡眠剥夺诱导的海马血管内皮损伤及后续神经炎症和神经功能障碍
Hao Yang,Sirou Huang,Yiwen Ma et al.
Hao Yang et al.
Sleep deprivation (SD) is a significant public health concern and a recognized risk factor for cognitive impairment. While both vascular dysfunction and neuroinflammation are implicated, the mechanistic link between them remains elusive. He...
Calcaratarin D exerts neuroprotective effects in Alzheimer's disease mouse model by inhibiting CERT-mediated NF-κB pathway [0.03%]
卡尔卡塔林D通过抑制CERT介导的NF-κB途径在阿尔茨海默病小鼠模型中发挥神经保护作用
Jin-Zhi Pan,Meng-Yao Yu,Ming-Zhu Tian et al.
Jin-Zhi Pan et al.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by β-amyloid plaque accumulation, neuroinflammation, and dysregulation of sphingolipid metabolism, mainly manifested as irreversible cognitive decline and memory loss. A...
Near-infrared light improves postoperative cognitive dysfunction by alleviating Lcn2-dependent ferroptosis induced neuronal injury [0.03%]
近红外光通过缓解Lcn2依赖性铁死亡诱导的神经元损伤来改善术后认知功能障碍
Junying Zhong,Li Li,Longjie Hou et al.
Junying Zhong et al.
Background: Iron overload and oxidative stress significantly contribute to the pathophysiology of postoperative cognitive dysfunction (POCD). Our previous findings demonstrated that transcranial near-infrared (NIR) light ...
Levodopa differentially modulates spectral features in cerebellum and basal ganglia in a rodent model of Parkinson's disease [0.03%]
左旋多巴在帕金森病动物模型中选择性调节小脑和基底节的谱特征
Shelby Sabourin,Kelly Modi,Jack Williams et al.
Shelby Sabourin et al.
The cerebellum has largely remained overlooked for its role in Parkinson's disease (PD). Interrogation of this motor system may reveal innovative targets for therapeutics for PD. Here, we investigate longitudinal changes in spatiospectral d...
Excitation-inhibition imbalance as a common thread linking early Alzheimer's disease with temporal lobe epilepsy [0.03%]
兴奋性-抑制性失衡作为早期阿尔茨海默病与颞叶癫痫的共通联系
Nwife Getrude Okechukwu,Claudio Zaccone,Livia La Barbera et al.
Nwife Getrude Okechukwu et al.
Growing evidence suggests that network hyperexcitability is a pivotal yet under-recognized pathology linking early Alzheimer's disease (AD) with mesial Temporal Lobe Epilepsy (mTLE). This narrative review synthesises pre-clinical and clinic...
Juquan Song,Balaji Krishnan,Nisha J Garg
Juquan Song
Burn injuries pose a substantial global health concern, impacting patients both acutely and profoundly in the long term. We elucidate key factors driving burn pathophysiology, moving beyond the initial wound to emphasize the resulting syste...
Optimizing functional recovery after acute ischemic stroke through intensity and frequency of rehabilitation: The critical role of HIF-1α/PLD2/mTOR signaling mechanisms [0.03%]
缺血性脑卒中后功能恢复的优化：低氧诱导因子HIF-1α/PLD2/mTOR信号机制发挥关键作用
Qingzhu Wang,Yanna Tong,Yuchuan Ding et al.
Qingzhu Wang et al.
Objectives: This study aims to identify the most optimal rehabilitation strategy for acute ischemic stroke recovery by examining the effects of different mobilization intensities and frequencies, and investigating the und...
TET3 SUMOylation enhances neuronal DNA damage repair and neuroprotection after ischemic stroke [0.03%]
TET3SUMO化增强缺血性脑卒中后的神经元DNA损伤修复和神经保护作用
Ye Pang,Hui Huang,Guangsheng Wang et al.
Ye Pang et al.
Ischemic stroke causes significant neuronal DNA damage, but the mechanisms regulating DNA repair remain unclear. This study investigates the role of Ten-eleven translocase 3 (TET3) in DNA damage repair and its potential neuroprotective effe...
Early deep brain stimulation attenuates parkinsonism progression in a neurotoxin-induced Parkinson's disease mouse model [0.03%]
早期进行深部脑刺激可减轻神经毒素诱导的小鼠帕金森病的病情进展
Miguel Cesar Merino Ruiz,Jair Trapé Goulart,Gabriely Dos Santos Penha et al.
Miguel Cesar Merino Ruiz et al.
Deep brain stimulation (DBS) is an effective symptomatic therapy for Parkinson's disease (PD). Although unproven in humans, animal studies suggest that DBS, when applied beyond the acute phase of parkinsonism induction, may be neuroprotecti...
Tracking remyelination in a model of multiple sclerosis: Visual evoked potentials reveal therapeutic effect from brain stimulation and exercise [0.03%]
追踪多发性硬化模型中的脱髓鞘和再髓鞘化：视觉诱发电位揭示了脑刺激和运动的治疗效果
Elena Rossi,Silvia Marenna,Valerio Castoldi et al.
Elena Rossi et al.
Visual evoked potentials (VEPs) represent an accurate, fast, and cost-effective diagnostic tool to evaluate visual function in multiple sclerosis (MS), and its use in preclinical research can support longitudinal monitoring of treatments ef...