Multimodal severity assessment using objective and quantitative indicators in a rat cisterna magna subarachnoid hemorrhage model [0.03%]
基于客观定量指标的脑池蛛网膜下腔出血模型多模态严重程度评估研究
Laura Warner,Ekaterina Harder,Annika Bach-Hagemann et al.
Laura Warner et al.
Assessing and minimizing animal distress is a critical ethical and scientific aspect of preclinical research. The EU Directive 2010/63 requires an assessment of the overall burden of animal experimentation in order to refine procedures and ...
Gut-microbiota-brain axis as a potential source of susceptibility/risk biomarkers for post-traumatic epilepsy: An opinion review [0.03%]
肠道微生物群-脑轴可能成为创伤后癫痫易感性/风险生物标志物的来源：意见综述
Andrey M Mazarati,Mulugeta Million,Muriel Larauche et al.
Andrey M Mazarati et al.
Both clinical and experimental evidence support the notion that traumatic brain injury (TBI) through the top-down dysregulation of gut-microbiota-brain axis (GMBA) profoundly affects the function and structural integrity of the gut, and tha...
Rapid hippocampal kindling of mice as a model of sudden unexpected death in temporal lobe epilepsy [0.03%]
快速海马致痫的小鼠模型在颞叶癫痫突发意外死亡中的作用
Selena N Garcia DuBar,Sebastian Moeller Rivera,Miranda L Sculimbrene et al.
Selena N Garcia DuBar et al.
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of seizure-related death in people with epilepsy. Yet, its mechanisms remain poorly understood. While most epilepsy syndromes have no known genetic component, animal SUDEP mod...
The LncRNA CRNDE/miR-152-3p/ROCK1 axis aggravates neurological deficits and neuroinflammation in intracerebral hemorrhage [0.03%]
长链非编码RNA CRNDE通过miR-152-3p/ROCK1轴加重脑出血后神经功能缺损和神经炎症损伤
Junli Xiao,Ming Wang,Haiyan Zuo et al.
Junli Xiao et al.
Objective: Intracerebral hemorrhage (ICH) is a fatal cerebrovascular disease. This study explored the intrinsic relationship between ICH and lncRNA CRNDE. ...
Age-related trajectories in Epileptogenesis and neurological function in an experimental model of post-traumatic epilepsy [0.03%]
一种外伤性癫痫的小鼠模型中癫痫发作及相关脑功能的年龄相关变化轨迹研究
Lauren Franklin,Sreevidhya Ramakrishnan,Doodipala Samba Reddy
Lauren Franklin
Post-traumatic epilepsy (PTE) is a debilitating long-term consequence of traumatic brain injury (TBI), yet the influence of age on epileptogenesis and neurological recovery remains insufficiently understood. Despite the high prevalence of T...
Neuromodulation for psychological sequelae of traumatic brain injury [0.03%]
神经调控在创伤性脑损伤后的心理 sequelaes 中的应用
Chunyan Li,Anjali LeDoux,Bernadette Tam et al.
Chunyan Li et al.
Traumatic brain injury (TBI) frequently precipitates chronic psychological disorder, particularly anxiety, depression, post-traumatic stress disorder (PTSD), and increased suicide risk, that worsen with injury severity yet remain understudi...
Mesenchymal stem cell-derived secretome in traumatic brain injury: Stage-specific paracrine mechanisms and translational challenges [0.03%]
创伤性脑损伤中间充质干细胞分泌组的作用：阶段特异性旁分泌机制和转化挑战
Jingtao Huang,Wenjun Zhang,Guanlin Huang et al.
Jingtao Huang et al.
Traumatic brain injury (TBI) is a stage-dependent disorder that evolves from acute neuroinflammation, blood-brain barrier (BBB) disruption, oxidative stress, excitotoxicity, and apoptosis to subacute neurovascular remodeling and chronic imp...
TGFα plays essential roles in angiogenesis and cognitive recovery after ischemic stroke [0.03%]
TGFα在缺血性脑卒中后血管生成和认知恢复方面发挥重要作用
Aditi Junagade,Eric Peng,Xuejiao Dai et al.
Aditi Junagade et al.
Stroke is a major global health issue and imposes a financial burden on survivors and caregivers. Current treatments for ischemic stroke, such as intravenous thrombolysis and endovascular thrombectomy, have strict time constraints, leaving ...
β-Hydroxybutyrate induces histone H3 β-hydroxybutyrylation and attenuates diabetic brain microvascular endothelial hyperpermeability [0.03%]
β-羟基丁酸诱导组蛋白H3的β-羟基丁酰化并减弱糖尿病脑微血管内皮高通透性
Le Liu,Runxi Yi,Yu Wang et al.
Le Liu et al.
Although the main ketone body β-hydroxybutyrate (BHB) exerts multiple protective roles in the brain, it remains unclear whether BHB can up-regulate tight junction proteins and antagonize brain microvascular endothelial hyperpermeability in...
Intranasal ketamine attenuates neuronal damage and behavioral deficits following mild fluid percussion injury [0.03%]
鼻内给药氯胺酮减轻轻度液体撞击伤大鼠的神经元损伤及行为缺损
Mohd Aleem,Princy Verma,Harshita Sharma et al.
Mohd Aleem et al.
Mild traumatic brain injury (mTBI) induces neuronal swelling, dendritic distortion, and microvascular damage. Following the initial insult, neurons undergo depolarization, triggering cortical spreading depolarization (SD) that contributes t...