Acute spinal cord injury-acquired pneumonia induces sustained lung injury in mice [0.03%]
急性脊髓损伤获得性肺炎诱导小鼠持续肺损伤
Ananya Das,Anish Sairam,Lisa Baer et al.
Ananya Das et al.
Systemic immunosuppression is a devastating result of spinal cord injury (SCI), leaving many patients susceptible to infections such as pneumonia. SCI-associated pneumonia (SCI-AP) is a clinically-relevant outcome modifier associated with i...
Let-7d-5p improves mouse cognitive function by targeting bach1 in Alzheimer's disease [0.03%]
Let-7d-5p通过靶向Bach1改善阿尔茨海默病模型小鼠的认知功能
Yu Liu,Lang Peng,Ming Li et al.
Yu Liu et al.
Background: MicroRNAs (miRNAs) have emerged as critical modulators in Alzheimer's disease (AD) pathogenesis. The lethal-7 (let-7) family functions as key regulators of cell apoptosis, differentiation, and immune response....
Absence of thyroid hormone transporters Mct8/Oatp1c1 causes distinct spinal cord alterations in adult female mice [0.03%]
甲状腺激素转运蛋白Mct8/Oatp1c1的缺失导致成年雌性小鼠脊髓出现特异性改变
Andrea Alcaide-Martin,Bettina Budeus,Reinhard Bauer et al.
Andrea Alcaide-Martin et al.
Thyroid hormone (TH) is critical for a normal development of the nervous system and the maintenance of adult CNS functions. As a prerequisite of its cellular action, TH is taken up across CNS barriers and further into target cells by specia...
Absence of thyroid hormone transporters Mct8/Oatp1c1 causes distinct spinal cord alterations in adult female mice [0.03%]
甲状腺激素转运蛋白Mct8/Oatp1c1缺失导致成年雌性小鼠脊髓出现差异化的改变
Andrea Alcaide-Martin,Bettina Budeus,Reinhard Bauer et al.
Andrea Alcaide-Martin et al.
Thyroid hormone (TH) is critical for a normal development of the nervous system and the maintenance of adult CNS functions. As a prerequisite of its cellular action, TH is taken up across CNS barriers and further into target cells by specia...
Tet1-mediated 5-hydroxymethylcytosine alterations in the olfactory bulb are associated with aberrant neurogenesis and PI3K-Akt signaling in response to CIH [0.03%]
缺氧通过PI3K-Akt信号异常调控神经发生及嗅球中 Tet1介导的5hmC变化
Yaru Kong,Yuwei Qi,Jiajia Dong et al.
Yaru Kong et al.
Chronic intermittent hypoxia (CIH), a key feature of obstructive sleep apnea, impairs central nervous system function, but its effects on olfactory bulb (OB) and epigenetic mechanisms are unclear. We show that CIH causes olfactory behaviora...
Enhanced therapeutic effect of intracavitary mesenchymal stromal cell administration with alginate scaffold in acute intracerebral hemorrhage model rat after hematoma aspiration [0.03%]
藻酸盐支架增强间充质基质细胞在颅内血肿穿刺清除大鼠后的腔内递送效应
Zheng Li,Kota Kurisu,Masahito Kawabori et al.
Zheng Li et al.
In order to develop a novel treatment for intracerebral hemorrhage (ICH), the cavity formed after hematoma evacuation is reasonable therapeutic target, given that secondary brain injuries are triggered and evolve from this cavity. We concei...
Impaired Glur2 palmitoylation in cerebellar Purkinje cells of a Friedreich ataxia mouse model [0.03%]
弗里德reich共济失调小鼠模型中浦肯野神经元GLUR2棕榈酰化障碍
Elizabeth Mercado-Ayón,Jennifer Coulman,Jia-Ying Lee et al.
Elizabeth Mercado-Ayón et al.
Friedreich's ataxia (FRDA) is a neurodegenerative disorder caused by frataxin deficiency, characterized by progressive cerebellar dysfunction and neuronal loss. Although synaptic abnormalities are an early feature of FRDA, the molecular mec...
Alzheimer's disease as a disorder of time-gated clearance: Circadian regulation of Glymphatic function in neurodegeneration [0.03%]
阿尔茨海默病作为门控清除功能紊乱的一种疾病：神经退行性疾病中甘淋巴系统功能的昼夜调节机制
Dipita Bhakta-Guha,Gunjan Guha
Dipita Bhakta-Guha
Alzheimer's disease (AD) is traditionally defined by amyloid-β (Aβ) accumulation, tau pathology, synaptic dysfunction, and progressive neurodegeneration. However, increasing evidence suggests that impaired brain waste clearance represents...
Gpr158 deficiency alleviates co-occurring motor and anxiety-like deficits after spinal cord injury in a partially dissociable manner [0.03%]
Gpr158缺失以部分解离的方式缓解脊髓损伤后的共病运动和焦虑样缺陷
Lei Guo,Haizhen Li,Xinyue Ning et al.
Lei Guo et al.
Spinal cord injury (SCI) is traditionally viewed as a neurological disorder characterized predominantly by motor dysfunction, yet anxiety-like and social behavioral abnormalities frequently co-occur and substantially impair functional outco...
Aerobic exercise improves cognition in sepsis-associated encephalopathy by enhancing glucose metabolism through astrocytic GLUT1 [0.03%]
有氧运动通过星形胶质细胞GLUT1增强糖代谢改善脓毒症相关性脑病的认知识别能力
Wenbo Liu,Qiuting Zeng,Wenlan Cai et al.
Wenbo Liu et al.
Sepsis-associated encephalopathy (SAE) is a common neurological complication of sepsis and a major cause of persistent cognitive impairment in survivors. In recent years, aerobic exercise has attracted increasing attention for its potential...