The BET degrader BETd-246 demonstrated significant anti-tumor efficacy in T-cell acute lymphoblastic leukemia by inhibiting TRAT1 [0.03%]
BET降解剂BETd-246通过抑制TRAT1在T细胞急性淋巴细胞白血病中展示出显著的抗肿瘤效果
Haixia Ge,Huike Bai,Juanjuan Yu et al.
Haixia Ge et al.
T cell acute lymphoblastic leukemia (T-ALL) is a rare lymphoblastic leukemia characterized by T lymphocyte heterogeneity and diverse genetic abnormalities, accounting for approximately 15% of childhood leukemias. BETd-246 serves as a tether...
Epitranscriptomic analysis reveals features of NAD-capped RNAs upon supplementation of nicotinamide mononucleotide in human [0.03%]
补充烟酸单核苷酸的人类的表转录组分析揭示了NAD帽RNA的特征
Shuwen Ge,Yandong Liu,Dean Li et al.
Shuwen Ge et al.
Nicotinamide mononucleotide (NMN), a precursory metabolite of NAD, has been demonstrated to boost cellular NAD level that is coupled with various age-related beneficial effects in animal models. NAD-capped RNA (NAD-RNA) represents a critica...
Harish C Chandramoorthy,Raed Obaid Saleh,Viralkumar Mandaliya et al.
Harish C Chandramoorthy et al.
The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has recently been characterized as a major player in cancer-related inflammation, tumor progression, immune modulation, and metastasis. The role of extracellular ves...
Targeting Glutaminase C, a splice variant of Glutaminase 1, Suppresses Smooth Muscle Cell Phenotypic Modulation and Neointimal Hyperplasia [0.03%]
靶向谷氨酰胺酶C（谷氨酰胺酶1的剪接变体）可抑制平滑肌细胞表型转化和内膜过度增生
Ankan Sarkar,Bhavneesh Kumar,Ashok K Yadav et al.
Ankan Sarkar et al.
Smooth muscle cell (SMC) phenotypic modulation plays a pivotal role in vascular proliferative disorders. During proliferation, SMCs utilize glutamine to fulfill their energy, biosynthesis, and redox needs. Glutaminase C (GAC), a splice vari...
Suppressor of Tumorigenicity 14 inhibits non-small cell lung cancer cell proliferation by suppressing Transketolase O-GlcNAcylation [0.03%]
抑癌因子ST14通过抑制己酮糖激酶O-连接的N-乙酰葡萄糖胺化抑制非小细胞肺癌细胞增殖
Lei Ji,Maowei Zhang,Yanan Liu et al.
Lei Ji et al.
Suppressor of Tumorigenicity 14 Protein (ST14), a type II transmembrane serine protease, is a well-documented oncogenic driver in multiple malignancies. Paradoxically, its pathobiological functions in non-small cell lung cancer (NSCLC) rema...
A time course analysis of the electrophysiological and gene expression properties during differentiation of hair cell-like cells in culture [0.03%]
体外培养过程中类毛细胞分化的时间进程的电生理和基因表达性质分析
Ali Asghar Peyvandi,Shima Davoudi,Narges Bazgir et al.
Ali Asghar Peyvandi et al.
Bone marrow-derived mesenchymal stromal cells (BMSCs) are multipotent cells that have attracted considerable attention in regenerative medicine. Current in vitro test focus on biochemical assays of hair cell-like cells (HCLCs) derived from ...
Human trophoblast stem cell-differentiated syncytiotrophoblasts as a model for hypoxia-enhanced secretion of the anti-angiogenic factor sFLT1 [0.03%]
人滋养细胞干细胞定向合体滋养外胚层分化物作为低氧增强分泌抗血管生成因子sflt1的模型
Tadashi Sasagawa,Masabumi Shibuya
Tadashi Sasagawa
Preeclampsia (PE) is a major disease in the field of obstetrics. Onset and progression of PE are associated with abnormally high serum levels of soluble fms-like tyrosine kinase-1 (sFLT1), an anti-angiogenic factor primarily secreted by syn...
SOCS1 orchestrates ferroptotic renal injury via GPX4 ubiquitination in hyperuricemia [0.03%]
SOCS1通过GPX4泛素化调控高尿酸血症肾细胞铁死亡损伤
Renzhong Zhang,Xu Fu,Xiaoli Zhao et al.
Renzhong Zhang et al.
Hyperuricemia (HUA)-induced renal injury involves elusive molecular mechanisms. This study uncovers suppressor of cytokine signaling 1 (SOCS1) as a pivotal mediator of hyperuricemic nephropathy through ferroptosis regulation. In a murine HU...
Tumor cell-derived DNASE2B mediates M2 macrophage infiltration to promote prostate cancer progression through the PSA secretion [0.03%]
肿瘤细胞来源的DNASE2B通过PSA介导M2型巨噬细胞浸润促进前列腺癌进展
Yulin Dai,Junkai Xu,Yunhui Zhao et al.
Yulin Dai et al.
This study sought to explore the role of DNASE2B (deoxyribonuclease II beta), a gene specifically overexpressed in prostate cancer (PCa) whose mechanism in driving disease progression remains unclear. We analyzed DNASE2B expression in the T...
Inhibition of USP18 in the presence of IFN-α elevates apoptosis, autophagy, and chemosensitivity of oesophageal cancer cell lines [0.03%]
干扰素存在下抑制USP18可增强食管癌细胞系的凋亡、自噬和化疗敏感性
M M Carey,T R O&#x;Donovan,C M Coveney et al.
M M Carey et al.
Oesophageal cancer remains a poor-prognosis disease with a five-year survival of 20%. Chemoresistance poses a significant challenge, and its mechanisms remain unclear. Our previous study found that the ISGylation network is differentially e...