The Innate Regenerome: Harnessing Mesenchymal Niches and Engineered Cytotoxic Killers for Solid Tumor Immunotherapy [0.03%]
肿瘤内在再生药学：利用间充质生态位和工程细胞毒性杀手进行实体瘤免疫治疗
Amr Ali Mohamed Abdelgawwad El-Sehrawy,Usamah Sayed,Aslonov Farrukh et al.
Amr Ali Mohamed Abdelgawwad El-Sehrawy et al.
Solid tumors evade adaptive immunity through MHC class I downregulation, stromal barricades, and T-cell exhaustion, rendering conventional immunotherapies ineffective in "cold" lesions. This review introduces the Innate Regenerome, a unifie...
Neddylation Cooperates with Multiple Phosphorylation to Enhance FGFR1 Stability and Drive Breast Cancer Progression [0.03%]
Neddylation与多种磷酸化合作增强FGFR1稳定性并驱动乳腺癌进展
Yongjun Du,Dezhou Ning,Jing Yu et al.
Yongjun Du et al.
Background: Fibroblast growth factor receptor 1 (FGFR1) is frequently overexpressed in breast cancer (BC), yet the mechanisms governing its protein stabilization remain unclear. This study investigates the role of neddyla...
Upregulation of PTEN mediated by FTO-m6A-YTHDF2 improves airway epithelial barrier damage and inflammation in asthma by inhibiting endoplasmic reticulum stress [0.03%]
FTO-m6A-YTHDF2介导的PTEN上调通过抑制内质网应激改善哮喘气道上皮屏障损伤和炎症
Junwei Li,Dan Wang,Yan Zhang et al.
Junwei Li et al.
Phosphatase and tensin homolog deleted on chromosome ten (PTEN) alleviates airway remodeling in asthmatic mice by inhibiting CD38 protein expression. Dysregulation of PTEN expression mediated by N6-methyladenosine (m6A) regulators is involv...
Targeting the MAPK/ERK Signaling Pathway: Mechanistic Analysis of Pexidartinib in Overcoming Adriamycin Resistance in Breast Cancer [0.03%]
靶向MAPK/ERK信号通路：帕昔達替尼克服乳腺癌阿霉素耐藥性的機制分析
Rujue Peng,Yujie Zhan,Zhenjie Cheng et al.
Rujue Peng et al.
Background and purpose: Breast cancer severely threatens women's health, adriamycin (Doxorubicin), as the first-line chemotherapy drug for breast cancer, has a serious problem of drug resistance, which severely restricts ...
Exosomes from bone marrow mesenchymal stem cells inhibit osteoclast differentiation and alleviate osteoporosis via RBM15B/YAP1 to induce autophagy [0.03%]
骨髓间充质干细胞源外泌体通过RBM15B/YAP1诱导自噬抑制破骨细胞分化和缓解骨质疏松症
Yongxian Wan,Yanshu Zhang,Jie Shi
Yongxian Wan
Background: Osteoporosis develops primarily as a result of an imbalance between osteoclastic bone resorption and osteoblastic bone formation. Bone marrow mesenchymal stem cells-derived-exosomes (BMSCs-Exos) regulate osteo...
Aconitine promotes injured peripheral nerve recovery through restraining the activation of inflammasome-mediated cell pyroptosis and pathological inflammation [0.03%]
乌头素通过限制炎性小体介导的细胞炎性坏死和病理炎症促进损伤外周神经恢复
Rui Li,Juerong Feng,Zhuoyu Wen et al.
Rui Li et al.
Peripheral nerve injury (PNI) represents a common neurological condition with significant social and economic implications. Aconitine, a diterpenoid alkaloid derived from Aconitum species, exhibits potent anti-cancer, anti-viral, anti-infla...
Peimisine ameliorates diabetic nephropathy by attenuating inflammation and ferroptosis through inhibition of the JAK/STAT pathway [0.03%]
.peimis通过抑制JAK/STAT通路来缓解糖尿病肾病中的炎症和铁死亡作用于糖尿病肾病
Junsheng Qu,Shihua Wang,Jie Wang et al.
Junsheng Qu et al.
This study aimed to investigate the effect of peimisine on diabetic nephropathy (DN) and explore its potential mechanisms in a mouse model of high-fat diet and streptozocin-induced DN and cell model of high glucose (HG)-treated MPC5 cells. ...
ALYREF drives NLRP3 inflammasome-dependent macrophage pyroptosis to promote sepsis-associated acute liver injury by enhancing GADD45A mRNA stability [0.03%]
ALYREF通过增强GADD45A mRNA稳定性促进NLRP3炎性小体依赖的巨噬细胞焦亡从而加重脓毒症相关急性肝损伤
Yanfang Pei,Zheng Tan,Yan Cao et al.
Yanfang Pei et al.
Sepsis-associated acute liver injury (SALI) is an independent risk factor that significantly worsens sepsis prognosis, underscoring the need for mechanistic insights to guide targeted therapy. Accordingly, we established a sepsis mouse mode...
Retraction notice to "Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway" [Exp. Cell Res. 361 (2017) 342-352] [0.03%]
撤稿：促红细胞生成素通过调节微胶质细胞极化来缓解蛛网膜下腔出血后的早期脑损伤[实验细胞研究，361（2017）342—352]
Shanwu Wei,Chunxia Luo,Shanping Yu et al.
Shanwu Wei et al.
METTL3-Mediated m6A Modification Stabilizes COL1A1 mRNA to Promote Extracellular Matrix Accumulation in Keloids [0.03%]
METTL3介导的m6A修饰通过稳定COL1A1 mRNA促进瘢痕中细胞外基质积累
Yanbin Zhai,Xiaofei Wang,Wanli Guo et al.
Yanbin Zhai et al.
Keloids are pathological scars characterized by excessive collagen deposition and fibroblast hyperactivity, yet effective therapies remain limited due to incomplete understanding of their molecular drivers. Emerging evidence implicates N6-m...