Bioinformatics Analysis of PLAUR and Its Oncogenic Role of Promoting Colorectal Cancer Progression Through the AKT/p53 signaling [0.03%]
PLAUR的生物信息学分析及其通过AKT/p53信号促进结直肠癌进展的致癌作用
You Chen,Rui Ma,Chuyue Wang et al.
You Chen et al.
Cancer is a significant global health challenge, driving an urgent need to uncover novel therapeutic strategies, including for colorectal cancer (CRC). Elevated expression of the plasminogen activator, urokinase receptor (PLAUR) has been re...
MicroRNA-124-3p suppresses lung cancer by targeting ITGB1/PI3K/p-AKT signal transduction pathway [0.03%]
微小核糖核酸-124-3p通过靶向ITGB1/PI3K/p-AKT信号转导途径抑制肺癌发生发展的作用研究
Ruiyun Han,Shunjuan Wang,Zhen Zhou et al.
Ruiyun Han et al.
Worldwide, lung cancer is a leading cause of cancer-related death, and non-small cell lung cancer (NSCLC) represents the most common histological subtype. Numerous studies have demonstrated that microRNAs (miRNAs) play critical roles in NSC...
MicroRNA-Mediated Metabolic Control in HCC: From Molecular Networks to Therapy [0.03%]
肝癌中微小核糖核酸介导的代谢调控：从分子网络到治疗
Dhuha D M Alrawi,Shahd Rajab Farhan,Ali G Alkhathami et al.
Dhuha D M Alrawi et al.
Hepatocellular carcinoma (HCC) is the most common histological subtype of primary liver cancer, accounting for nearly 80-90% of all liver cancer cases. While 'liver cancer' refers broadly to all malignant tumors arising in the liver (includ...
IL-33/ST2 signaling promotes intrahepatic cholangiocarcinoma through reprogramming macrophage polarization via MAPK pathway [0.03%]
白细胞介素33/ST2信号通过MAPK途径极化巨噬细胞促进肝内胆管癌发展
Aimaiti Yasen,Yichen Tang,Xiaomin Yang et al.
Aimaiti Yasen et al.
Background: The role of IL-33/ST2 signaling in reprogramming macrophage polarization within the intrahepatic cholangiocarcinoma (ICC) microenvironment remains poorly understood. This study aimed to elucidate the mechanism...
SLBP Promotes Lung Adenocarcinoma Progression by Inhibiting Ferroptosis and Reprogramming Glutamine Metabolism via FADS2 Interaction [0.03%]
SLBP通过与FADS2相互作用抑制铁死亡并重新编程谷氨酰胺代谢从而促进肺腺癌进展
Wei Yan,Pengfei Xu,Dan Xiao et al.
Wei Yan et al.
SLBP is significantly overexpressed in lung adenocarcinoma (LUAD) and correlates strongly with poor patient prognosis. Functional studies demonstrated that SLBP potently enhances proliferation, invasion, and metastasis of LUAD cells both in...
miR-98-3p/VEGFA axis mediates MALAT1-induced angiogenesis in ovarian tumors [0.03%]
MALAT1通过miR-98-3p/VEGFA轴诱导卵巢肿瘤血管生成的作用及机制研究
Mengxin Zhang,Yu Zhang,Jiabao Xu et al.
Mengxin Zhang et al.
The functional role of MicroRNA miR-98-3p in ovarian cancer is largely unexplored and its molecular mechanisms remain incompletely understood. In this study, we identified a novel regulatory axis involving MALAT1, miR-98-3p, and VEGFA in ov...
Mulberry leaf flavonoid extract inhibits high glucose-induced ferroptosis by regulating the PI-3K/Akt/Nrf2/GPX4 pathway in HT22 mouse hippocampal neuronal cells [0.03%]
桑叶黄酮提取物通过调节PI-3K/Akt/Nrf2/GPX4信号通路抑制高糖诱导的HT22小鼠海马神经元细胞铁死亡
Fan Yang,Liang Li,Tao Chai et al.
Fan Yang et al.
Objective: To explore the inhibitory effects of mulberry leaf flavonoid extract (MFE) on high glucose-induced diabetic encephalopathy (DE) in a cell model, and to investigate the underlying mechanisms combined with networ...
microRNA-100 inhibits cell division in human non-small cell lung cancer via a CDC25A signaling mechanism [0.03%]
MicroRNA-100通过活化CDC25A信号通路抑制人类非小细胞肺癌的细胞增殖
Mo Xu,Zhijun Chen,Fan Yang et al.
Mo Xu et al.
Lung cancer is one of the most common malignancies worldwide, and the prognosis remains unsatisfactory with conventional treatments. Our research revealed that miR-100 is significantly decreased in non-small cell lung cancer (NSCLC) tissues...
Ferroptosis modulates invasion and migration in prostate cancer PC-3M subclones [0.03%]
铁死亡调节前列腺癌PC-3M亚克隆的侵袭和迁移
Yuliang Rao,Siyu Liu,Aicui Ma et al.
Yuliang Rao et al.
Prostate cancer (PCa) metastasis remains a formidable clinical challenge, underscoring the urgent need to uncover its underlying molecular mechanisms. Leveraging the PC-3M cell line and its sublines with divergent metastatic potentials (PC-...
Histone H3 lysine 18 lactylation promotes alveolar epithelial cell apoptosis in sepsis-induced lung injury by upregulating caspase-8 in vivo and in vitro [0.03%]
组蛋白H3第18位赖氨酸乳酸化通过体内和体外上调caspase-8促进脓毒症诱导的肺损伤中Ⅱ型肺泡上皮细胞凋亡
Ping Lin,Yu Wang,Xiaoqian Li et al.
Ping Lin et al.
Background: Sepsis is a leading cause of acute lung injury (ALI), with apoptosis of alveolar epithelial cells (AECs) playing a central role. Elevated lactate, a hallmark of sepsis-induced metabolic reprogramming, has rece...