Yan-Ge Li,Meng-Yuan Hao,Hong-Jie Li et al.
Yan-Ge Li et al.
Paraptosis represents a mode of cell death, which is separate from classical apoptosis. Classical apoptotic pathways are caspase-dependent, accompanied by cell shrinkage, chromatin condensation, and apoptotic body formation. In contrast, pa...
CircRNA_38959 protects liver cells from intermittent hypoxia-triggered injury and suppresses ferroptosis by interacting with IGF2BP3 [0.03%]
Chaowei Li,Jinhuang Lin,Yanta Guo et al.
Chaowei Li et al.
Intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), is closely associated with liver injury and ferroptosis. However, the molecular mechanisms underlying IH-induced liver damage remain largely unexplored. Here, we identi...
ALPK1 promotes cardiomyocyte hypertrophy by activating NF-κB/NLRP3 inflammasome-mediated pyroptosis [0.03%]
Xiaomi Zhuang,Shuai Han,Zeyao Dong et al.
Xiaomi Zhuang et al.
Background: Cardiac hypertrophy is a leading risk factor for cardiovascular morbidity and mortality. Alpha-protein kinase 1 (ALPK1) is a novel essential player in innate immunity and inflammation. Therapeutic agents targe...
The ATF4/PSAT1/JNK Signaling Axis Suppresses Ferroptosis to Drive Venetoclax Resistance in AML [0.03%]
ATF4/PSAT1/JNK信号轴通过抑制铁死亡驱动AML中对维奈托克的耐药性
XunXun Zhu,WenHui Huang,MingYan Zhang et al.
XunXun Zhu et al.
Metabolic reprogramming has emerged as a key driver of therapy resistance in acute myeloid leukemia (AML). Here, we identify phosphoserine aminotransferase 1 (PSAT1) as a critical metabolic determinant of venetoclax (VEN) resistance through...
Yue Zhou,Yiqiang Liu,Yuesheng Lv et al.
Yue Zhou et al.
Despite the rational therapeutic premise of microRNA (miRNA) replacement or inhibition for cancer treatment, its clinical translation remains significantly constrained. Major challenges span from inherent molecular instability and off-targe...
Matrix stiffness disrupts tight junction integrity in retinal pigment epithelial cells via YAP1-mediated autophagy suppression [0.03%]
基质刚度通过YAP1介导的自噬抑制破坏视网膜色素上皮细胞紧密连接完整性
Songtao Wang,Yu Zhang,Ning Yang et al.
Songtao Wang et al.
Background: The extracellular matrix (ECM) of retinal pigment epithelial (RPE) cells undergoes progressive stiffening during aging and under pathological conditions. However, how such mechanical effects affect RPE cell fu...
The role of disease-modifying anti-rheumatic drugs (DMARDs) in cardiovascular risk management induced by rheumatoid arthritis [0.03%]
抗风湿病药物(DMARDs)在类风湿关节炎诱导的心血管风险控制中的作用
Yan Wang,Ning Zhang,Chun-Xia He et al.
Yan Wang et al.
Rheumatoid arthritis (RA) is a prevalent autoimmune disease affecting approximately 1% of the global population, which significantly increases the risks of cardiovascular disease (CVD). RA-associated cardiovascular risks, such as pericardit...
MDK promotes the mast cell activation and pancreatic fibrosis in mice with chronic pancreatitis via MDK-NCL signaling pathway [0.03%]
MDK通过MDK-NCL信号通路促进慢性胰腺炎小鼠肥大细胞活化和胰腺纤维化
Jianbin Xiong,Jian Song,Xing Jiang et al.
Jianbin Xiong et al.
Chronic pancreatitis (CP) is characterized by persistent inflammation and fibrosis in the pancreas, but its exact pathogenesis remains unclear. To investigate the underlying mechanisms, human CP single-cell RNA sequencing (scRNA-seq) data (...
Chemogenetic screen identifies EphA2 as a synthetic lethal vulnerability in MYC-driven triple-negative breast cancer [0.03%]
化学遗传筛选鉴定EphA2在MYC驱动的三阴性乳腺癌中的合成致死脆弱性
Meng Ye,Zixin Wang,Yuxin Wang et al.
Meng Ye et al.
The MYC oncoprotein is a key driver of various cancers and is particularly relevant in triple-negative breast cancer (TNBC), where its dysregulated activation promotes aggressive tumor growth, metastasis, and resistance to treatment. Despit...
The combinations of histone lysine demethylase inhibitors with panobinostat exert enhanced effects against head and neck cancer cells [0.03%]
组蛋白赖氨酸去甲基化酶抑制剂与帕比司他的联合使用可增强对头颈部癌细胞的作用
Dawid Dorna,Robert Kleszcz,Karolina Drabarz et al.
Dawid Dorna et al.
The effectiveness of treatment of head and neck squamous cell carcinomas (HNSCC) is still unsatisfactory, and novel therapeutics could improve outcomes. Histone deacetylases (HDAC) and histone lysine demethylases (KDMs) emerged as important...