PRDM5 regulates ASK1 transcription to affect macrophage inflammation, lipid accumulation and apoptosis progression [0.03%]
Mengchen Sun,Han Sun,Hanzheng Wang et al.
Mengchen Sun et al.
Background: Atherosclerotic cardiovascular disease (ASCVD) has shared genetic susceptibility across various vascular lesions. Identification of common pathogenic factors for multi-territorial atherosclerosis is urgently r...
CircUBE2I regulates YAP/TAZ signaling pathway through miR-659-3p/PSMA1 axis to promote human lung adenocarcinoma cell progression [0.03%]
circUBE2I通过miR-659-3p/PSMA1轴调控YAP/TAZ信号通路促进人肺腺癌细胞进展
Peini Xue,Yongheng Gao,Tianhao Li et al.
Peini Xue et al.
Circular RNAs (circRNAs) exhibit wide expression across human tissues and play pivotal roles in tumorigenesis and cancer progression. However, studies regarding the function and mechanism of circRNAs in lung adenocarcinoma (LUAD) are insuff...
IRF8 transcriptionally drives NAIP to promote NLRP3/NLRC4 inflammasome-mediated renal tubular pyroptosis in diabetic kidney disease [0.03%]
IRF8通过转录激活NAIP促进NLRP3/NLRC4炎性小体介导的糖尿病肾病管状上皮细胞焦亡
Xiaorong Zou,Rui Su,Xueyan Liang et al.
Xiaorong Zou et al.
Objective: Renal tubular pyroptosis is a key driver of inflammation and fibrosis in diabetic kidney disease (DKD), yet the contribution of the NAIP-NLRC4 inflammasome arm and its upstream transcriptional control have rema...
CTSB promotes ferroptosis in macrophage-derived foam cells and aggravates plaque instability via the NRF2/HMOX1 axis [0.03%]
CTSB通过NRF2/HMOX1轴促进巨噬细胞泡沫细胞的铁死亡并加重斑块不稳定性
Fan Gong,Xiaobin Wang,Weisong Mo et al.
Fan Gong et al.
Atherosclerosis is a chronic inflammatory vascular disease characterized by lipid accumulation and plaque formation, representing a leading cause of life-threatening cardiovascular events. Ferroptosis, an iron-dependent form of cell death d...
The bone vicious cycle: How the microenvironment drives osteosarcoma progression [0.03%]
恶性循环：基质如何驱动骨肉瘤进展
Liu Yang,Siyu Meng,Haolong Zhang et al.
Liu Yang et al.
Osteosarcoma progression cannot be fully explained by tumor-intrinsic genetic alterations alone; it is shaped by continuous interactions with the bone microenvironment. Emerging evidence indicates that osteosarcoma cells actively sense, app...
Ferroptosis in Vitiligo and Melanoma: Opposing Susceptibilities, Shared Mechanisms, and Therapeutic Targets [0.03%]
白癜风和黑色素瘤中的铁死亡：相反的易感性、共享的机制与治疗靶点
Chunyan Zhang,Faming Xu
Chunyan Zhang
Vitiligo is a common acquired depigmentation disorder affecting approximately 0.5-2% of the global population, characterized by the selective destruction of melanocytes leading to white patches on the skin. The pathogenesis of vitiligo invo...
High-altitude hypoxia remodels lipid metabolism in renal tubular epithelial cells by inhibiting the expression of HNF4α [0.03%]
高空低氧通过抑制HNF4α的表达重塑肾小管上皮细胞脂代谢
Ruihui Chen,Jiawu Li,Xinjian Guo et al.
Ruihui Chen et al.
A deficiency of fatty acid oxidation (FAO) is the key hallmark in renal tubular epithelial cells (TECs) under high-altitude hypoxia (HH), reflecting their physiological reliance on FAO as a major energy source. The resulting lipid accumulat...
Circ_PRKCA Drove NSCLC Progression via SRSF1/HIF-1A/PKM2 Axis-Mediated Glycolytic Reprogramming [0.03%]
circ_prkca通过srsf1/hif-1a/pkm2轴介导的糖酵解重塑驱动nsclc进展
Haiting Chen,Xingxing Jin,Leilei Tao et al.
Haiting Chen et al.
Elucidating the complex molecular drivers of non-small cell lung cancer (NSCLC) and identifying novel therapeutic targets are urgently needed. Although circPRKCA is implicated in tumorigenesis, its role in NSCLC remains poorly characterized...
From Contested Target to Context-Aware Node: A Three-Layer Regulatory Code for Interpreting FTO's Oncogene-Tumor Suppressor Paradox in Cancer [0.03%]
从 contested target（有争议的靶点）到 context-aware node（感知环境的节点）：FTO 在癌症中致癌基因/抑癌基因矛盾现象的三层调控代码解释机制
Ghaleb Oriquat,Sajida Hussein Ismael,Tushar B Gajjar et al.
Ghaleb Oriquat et al.
The fat mass and obesity-associated protein (FTO), the first identified N6-methyladenosine (m6A) RNA demethylase, has become both a leading candidate target in oncology and one of its most contested, behaving as an oncogene in some malignan...
Retraction notice to "Tumor necrosis factor α stimulates endothelin-1 synthesis in rat hepatic stellate cells in hepatic wound healing through a novel IKK/JNK pathway" [Exp. Cell Res. 317 (2011) 1040-1048] [0.03%]
有关“肿瘤坏死因子α通过一种新的IKK / JNK途径刺激大鼠肝星状细胞中内皮素-1合成在肝创伤愈合中的作用”的文章的撤稿通知[实验细胞研究 317（2011）1040-1048]
Shuxin Zhan,Don C Rockey
Shuxin Zhan