The effect of tocilizumab treatment for skin fibrosis by inhibiting CD38+ macrophages in systemic sclerosis [0.03%]
托珠单抗通过抑制CD38+巨噬细胞治疗系统性硬化病皮肤纤维化的影响
Hongzhen Chen,Dapeng Yang,Yirui Shi et al.
Hongzhen Chen et al.
Background: Dermal and pulmonary fibrosis are the main clinical symptoms of systemic scleroderma (SSc), for which there are no effective therapeutic agents. Tocilizumab is thought to improve the symptoms of fibrosis, but ...
Sodium butyrate prevents lipopolysaccharide induced inflammation and restores the expression of tight junction protein in human epithelial Caco-2 cells [0.03%]
丁酸钠通过防止脂多糖诱导的炎症和恢复紧密连接蛋白表达来保护Caco-2细胞损伤
Jyotsana Bakshi,K P Mishra
Jyotsana Bakshi
The gastrointestinal (GI) tract is susceptible to damage under high altitude hypoxic conditions, leading to gastrointestinal discomfort and intestinal barrier injury. Sodium butyrate, a short-chain fatty acid present as a metabolite in the ...
Augmented IFNγ producing ILC1 and IL 17 producing ILC3 in pemphigus vulgaris: Plausible therapeutic target [0.03%]
天疱疮中增多的辅助性淋巴组织诱导细胞的作用及治疗意义
Vishakha Hooda,Sujay Khandpur,Alpana Sharma
Vishakha Hooda
Innate Lymphoid cells (ILCs) are innate counterparts of helper T cells. Although low in number, they have proven to play major roles in many autoimmune diseases. In Pemphigus Vulgaris (PV), the gaps in the knowledge of functional role of IL...
Enhanced apoptosis and inflammation allied with autophagic and apoptotic Leishmania amastigotes in the seemingly undamaged ear skin of clinically affected dogs with canine visceral Leishmaniasis [0.03%]
看似正常的皮肤中莱什曼原虫诱导的细胞凋亡和炎症与犬内脏利什曼病患者的自噬有关
Barbara Laurice Araújo Verçosa,Maria Imaculada Muniz-Junqueira,Ana Lys Bezerra Barradas Mineiro et al.
Barbara Laurice Araújo Verçosa et al.
Programmed cell death plays a relevant role in the pathogenesis of visceral Leishmaniasis. Apoptosis selects suitable parasites, regulating parasite density, whereas autophagy eliminates pathogens. This study aimed to assess the inflammatio...
Jinjin Xie,Xin Du,Yuke Li et al.
Jinjin Xie et al.
Pyroptosis is a programmed cell death (PCD) mainly mediated by the Gasdermin family of proteins, among which Gasdermin E (GSDME) is considered a tumor suppressor gene. GSDME can recruit immune cells to the tumor microenvironment (TME) and p...
P2RX1-blocked neutrophils induce CD8+ T cell dysfunction and affect the immune escape of gastric cancer cells [0.03%]
P2RX1阻断的中性粒细胞诱导CD8⁺ T细胞功能障碍并影响胃癌细胞免疫逃逸
Yan Zhang,Fenglin Zhang,Zhi Liu et al.
Yan Zhang et al.
Background: Gastric cancer (GC) is one of the deadly malignancies of the gastrointestinal tract. Research has confirmed the linkage of P2RX1 with immune cell activation and tumor progression. This project focused on the i...
Abtin Ghasempour,Rashin Mohseni,Pouya Mahdavi Sharif et al.
Abtin Ghasempour et al.
Neuroblastoma (NB) is the most common extracranial solid tumor of childhood forming around 15 % of all pediatric tumors. Despite advances in the treatment of NB, high-risk patients still face a grave prognosis. Adoptive cell therapies based...
Fan Fan Qu,Ya Qian Wu,Jian Bin Ji et al.
Fan Fan Qu et al.
Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease characterized mainly by inflammatory changes in the intestinal mucosa. While the specific etiology of UC remains unclear, it is generally believed that it is relate...
Immunomodulation by galectin-9: Distinct role in T cell populations, current therapeutic avenues and future potential [0.03%]
半乳糖凝集素9的免疫调节作用：不同T细胞群体中的独特作用、当前治疗途径和未来前景
Eva M Gossink,Paul J Coffer,Alessandro Cutilli et al.
Eva M Gossink et al.
Galectins, glycan-binding proteins, have been identified as critical regulators of the immune system. Recently, Galectin-9 (Gal-9) has emerged as biomarker that correlates with disease severity in a range of inflammatory conditions. However...
Ubiquitination and degradation of MHC-II by Tim-3 inhibits antiviral immunity [0.03%]
Tim-3介导MHC-II泛素化降解抑制抗病毒免疫响应
Jie Zhou,Zhonglin Lv,Meichen Liu et al.
Jie Zhou et al.
We previously reported that Tim-3, an immune checkpoint inhibitor, inhibits MHC-II expression, but the molecular mechanisms involved and the implications for antiviral immunity remain to be determined. Here, we found that during H1N1 infect...