Tim-3 promotes viral infection by suppressing the USP25-TRAF3-IRF7 signaling pathway [0.03%]
TIM-3通过抑制USP25-TRAF3-IRF7信号通路促进病毒感染
Lin Du,Jinjie Chen,Chunxiao Du et al.
Lin Du et al.
Tim-3, an immune checkpoint inhibitor, plays key roles in maintaining immune homeostasis and is involved in viral evasion. However, the precise role of Tim-3 in viral infection remains to be determined. USP25 is a deubiquitinating enzyme th...
The polarization of macrophages participates in the repair after folic acid-induced acute kidney injury [0.03%]
极化巨噬细胞参与叶酸诱导的急性肾损伤修复过程
Shujie Yang,Yan Shen
Shujie Yang
Acute kidney injury (AKI) remains a major public health challenge, posing serious threats to human health. Increasing evidence indicates that renal cells undergo significant metabolic alterations following AKI, with inflammatory responses p...
The double-edged sword role of natural Killer cells in Parkinson's disease [0.03%]
自然杀伤细胞在帕金森病中的双刃剑作用
Delbar Daneshjou,Seyed Masood Nabavi,Parisa Shams et al.
Delbar Daneshjou et al.
Neurological disorders are the leading cause of disability worldwide, with Parkinson's disease (PD) emerging as a rapidly growing neurological condition on a global scale. Although treatments exist to alleviate symptoms and maintain patient...
Arctiin suppress Th17 cells response and ameliorates experimental autoimmune uveitis through JAK/STAT signaling [0.03%]
茋类衍生物arctiin通过jak/stat信号通路抑制th17细胞应答并改善实验性自身免疫性葡萄膜炎
Xiao&#x;e Fan,Manhong Xu,Zhengmin Wang et al.
Xiao&#x;e Fan et al.
Conventional treatments for autoimmune uveitis, such as corticosteroids and systemic immunosuppressants, often result in adverse side effects, prompting the need for therapies targeting specific molecular pathways. This study investigates t...
Effect of high-fat diet on IgA+ cells and BAFF/APRIL in small intestinal villous lamina propria of mice [0.03%]
高脂饮食对小鼠小肠固有层IgA⁺细胞和BAFF/APRIL的影响
Yuta Sakamoto,Masatoshi Niwa,Ken Muramatsu et al.
Yuta Sakamoto et al.
Obesity exacerbates susceptibility to infectious diseases. We investigated the effects of a high-fat diet (HFD) on intestinal immunity, particularly immunoglobulin (Ig)A-producing cells, B-cell activating factor (BAFF), and a proliferation-...
IL-17 family members exert an autocrine pro-inflammatory loop in CF respiratory epithelial cells ex vivo [0.03%]
细胞因子IL-17家族成员通过自分泌途径促进囊性纤维化呼吸道上皮细胞炎症状况的加重
Caterina Allegretta,Enza Montemitro,Fabiana Ciciriello et al.
Caterina Allegretta et al.
Background: Lungs of people with Cystic Fibrosis (pwCF) are characterized by chronic inflammation and infection with P. aeruginosa. High levels of IL-17 A and F have been observed in sputum of pwCF and the interleukin-17(...
The distinct characteristic of two peritoneal macrophage subsets in a mouse model of hepatocellular carcinoma presents a novel therapeutic strategy [0.03%]
小鼠肝细胞癌模型中两种腹腔巨噬细胞亚群的显著特征提供了新的治疗策略
Wan-Li Yang,Chao Yang,Nan Pang et al.
Wan-Li Yang et al.
The peritoneal cavity (PerC) is a discrete anatomical compartment housing diverse peritoneal macrophage subpopulations. Nonetheless, there exists a paucity of knowledge concerning the distinct functions of these subpopulations in the contex...
KLHDC8A knockdown in normal ovarian epithelial cells promoted the polarization of pro-tumoral macrophages via the C5a/C5aR/p65 NFκB signaling pathway [0.03%]
敲除正常卵巢上皮细胞中的KLHDC8A通过C5a/C5aR/p65NF-κB信号通路促进促肿瘤巨噬细胞的极化
Jie Fang,Jin Wang,Xinyue Zhao et al.
Jie Fang et al.
Aims: Tumor-associated macrophages (TAM) is related to Ovarian cancer (OC) pathogenesis, but the exact mechanism remains unclear. This study investigated the expression of Kelch Domain Containing 8 A (KLHDC8A) in OC and t...
Deciphering the role of TMEM164 in autophagy-mediated ferroptosis and immune modulation in non-small cell lung cancer [0.03%]
TMEM164在非小细胞肺癌自噬介导的铁死亡和免疫调节中的作用机制研究
Tahani Ahmad ALMatrafi
Tahani Ahmad ALMatrafi
Background: Non-small cell lung cancer (NSCLC) remains one of the most prevalent and deadly malignancies. Despite advancements in molecular therapies and diagnostic methods, the 5-year survival rate for lung adenocarcinom...
Bacteriophage derived dsRNA induces polarized activation of alveolar macrophages from Balb/c and C57Bl/6 mice in vitro in sex- and age-dependent manner [0.03%]
一种噬菌体来源的双链RNA诱导小鼠肺泡巨噬细胞活化的极化现象具有性别和年龄依赖性
R Dovhyi,A Dvukhriadkina,K Ostrovska et al.
R Dovhyi et al.
Bacteriophage-derived dsRNA (bp-dsRNA), also known as Larifan, is a poly-functional and wide-spectrum antiviral medication with potent interferonogenic activity. In the lungs of golden Syrian hamsters infected with SARS-CoV-2, Larifan subst...