A new chimeric protein composed by T-cell epitopes from peroxidoxin and pyridoxal kinase proteins is protective against visceral leishmaniasis [0.03%]
一种由过氧化物酶体二硫异构酶和吡哆醛激酶T细胞表位组成的嵌合蛋白可保护小鼠免受内脏利什曼病的侵害
Daniela P Lage,Danniele L Vale,Marcela G P Silva et al.
Daniela P Lage et al.
Visceral leishmaniasis (VL) is a neglected tropical disease caused by intracellular protozoan parasites, and which present high incidence in populations in the world. The diagnosis is difficult to be performed, and treatment is toxic and/or...
Immunology of familial chorea-acanthocytosis with presenting generalized tonic-clonic seizure: Blood cell study for early diagnosis and management [0.03%]
chorea-acanthocytosis家系的免疫学研究（以全面性强直-阵挛性癫痫发作为首发症状）：用于早期诊断和治疗的血细胞研究
Amineh Salem,Narges Omidvar
Amineh Salem
A male, who involved familial chorea-acanthocytosis (ChAc), was introduced to provide direction for early diagnosis and management. The admitted patient was found to have the significant episode with generalized tonic-clonic seizure, gradua...
Simon Fillatreau
Simon Fillatreau
METTL3 promotes infantile pneumonia-induced lung injury by the m6A-TBL1XR1-ACSL1 axis [0.03%]
METTL3通过m6A-TBL1XR1-ACSL1轴促进婴儿肺炎引起的肺损伤
Fuxing Song,Fang Guo,Bo Su et al.
Fuxing Song et al.
Background: Methyltransferase-like 3 (METTL3) is the catalytic subunit of methyltransferase complex that catalyzes mRNA methylation and has been identified to be involved in lipopolysaccharide (LPS)-induced lung cell inju...
Dexmedetomidine modulates peritoneal macrophage to attenuate lipopolysaccharide-induced inflammation [0.03%]
右美托咪定通过调节腹膜巨噬细胞来减轻脂多糖诱导的炎症反应
Tao Wang,Rui Pan,Jianli Wen et al.
Tao Wang et al.
Purpose: To investigate how Dexmedetomidine (Dex) modulates the function of peritoneal macrophages (PMs) to reduce lipopolysaccharide (LPS)-induced inflammation. ...
USP14 inhibits sensitization-mediated degradation of KDM4D to epigenetically regulate dendritic cell tolerogenic capacity and mitigates airway allergy [0.03%]
USP14通过表观遗传学调节树突细胞的免疫耐受并缓解气道过敏反应
Aizhi Zhang,Huanping Zhang,Le Liu et al.
Aizhi Zhang et al.
Numerous immune disorders are caused by the dysfunction of dendritic cells (DC). The mechanism has not been fully comprehended yet. This research is designed to regulate the epigenetic status of lysine-specific demethylase 4D (KDM4D) to enh...
Divergent impact of endotoxin priming and endotoxin tolerance on macrophage responses to cancer cells [0.03%]
内毒素预激和内毒素耐受对巨噬细胞响应癌细胞的不同影响
Konkonika Roy,Tomasz Jędrzejewski,Justyna Sobocińska et al.
Konkonika Roy et al.
Endotoxin tolerance (ET) is an adaptive phenomenon that arises from the repeated exposure of immune cells, such as macrophages, to endotoxins like lipopolysaccharide (LPS). Initially, when macrophages are activated by LPS, they produce infl...
Nebulized mesenchymal stem cell-derived exosomes attenuate airway inflammation in a rat model of chronic obstructive pulmonary disease [0.03%]
雾化间充质干细胞衍生的外泌体可以减轻慢性阻塞性肺疾病大鼠模型的气道炎症
Min Wang,Yuxin Hao,Wei He et al.
Min Wang et al.
Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of death worldwide, and current treatments fail to significantly halt its progression. Exosomes derived from mesenchymal stem cells (MSCs-Exos) have demonstrated prom...
In vitro ovarian tumor-conditioned CD163+ human macrophages retain phagocytic response to CD47 blockade [0.03%]
体外卵巢肿瘤条件下CD163+人巨噬细胞保留了对CD47阻断的吞噬反应
Kristian W Antonsen,Anne G Jensen,Boe S Sorensen et al.
Kristian W Antonsen et al.
Introduction: CD163-expressing macrophages are abundant in ovarian cancer where they accelerate tumor growth and metastasis. CD47 blockade is a novel immunotherapy aiming to activate macrophage phagocytosis of tumor cells...
Breast cancer stem cells convert anti-tumor CD4+ T cells to pro-tumor T regulatory cells: Potential role of exosomal FOXP3 [0.03%]
乳腺癌干细胞转化抗肿瘤CD4+T细胞到促肿瘤的调节性T细胞中的作用：FOXP3胞外小泡的潜在角色
Udit Basak,Sourio Chakraborty,Sumon Mukherjee et al.
Udit Basak et al.
Cancer progression and its treatment-response are regulated by the tumor microenvironment (TME). Tumor-initiating cancer stem cells (CSCs) remain in constant communication with the TME, and modulate it through several mechanisms. Here, from...