miRNA-186-5p modulates placental inflammation via Inflammasome activation in gestational diabetes mellitus [0.03%]
miRNA-186-5p通过调控凋亡小体激活来调节妊娠糖尿病患者的胎盘炎症反应
Bhatnagar Megha,K L Milan,M Anuradha et al.
Bhatnagar Megha et al.
Inflammasomes are multiprotein complexes that initiate inflammatory responses by activating pro-inflammatory cytokines, playing a crucial role in innate immunity. However, their dysregulation can lead to excessive inflammation, particularly...
Potential therapeutic strategies targeting efferocytosis for inflammation resolution and tissue repair in inflammatory bowel disease [0.03%]
针对炎症性肠病中促炎症反应和组织修复的促凋亡治疗策略
Chaoquan Li,Wanting Liu,Aoni Fu et al.
Chaoquan Li et al.
Efferocytosis, the process by which apoptotic cells (ACs) are recognized and cleared by phagocytes, is a critical mechanism in maintaining intestinal immune homeostasis and promoting the resolution of inflammation. Inflammatory bowel diseas...
Transfer of bone marrow niche-residential regulatory T cells ameliorates experimental colitis [0.03%]
骨髓龛定植的调节性T细胞的转移可改善实验性结肠炎
Chen Meng,Tatsuyuki Sato,Ryosuke Ueda et al.
Chen Meng et al.
Background: Adoptive transfer of regulatory T cells (Tregs) has been proposed as a next-generation treatment approach for the treatment of various inflammatory or autoimmune disorders(Amini et al., 2022; Bluestone et al.,...
The real-world impact of corticosteroid-associated adverse events in myasthenia gravis: A patient-reported survey analysis [0.03%]
皮质类固醇相关不良事件在重症肌无力中的真实世界影响：患者报告的调查分析
Jinyi Yan,Kalam Choi,Peicai Fu et al.
Jinyi Yan et al.
Background: Corticosteroids are crucial for managing acute exacerbation symptoms and preventing relapses in myasthenia gravis (MG) patients. Methods: ...
Lupeol mitigates spinal cord injury by modulating microglial M1/M2 polarization via Na+/K+-ATPase-mediated mitophagy [0.03%]
卢泊醇通过钠钾泵介导的线粒体自噬调节小胶质细胞M1/M2极化缓解脊髓损伤
Ruyin Liu,Zongjin Yue,Jia&#x;an Dong et al.
Ruyin Liu et al.
Spinal cord injury (SCI) often results in severe disability or even death, with inflammation playing a critical role in hindering recovery. Although Lupeol is known for its potent anti-inflammatory properties, its specific role in SCI-induc...
Aged mice-derived bronchial epithelial cells regulate Th17 cell differentiation in asthma via the MBD2-sICOSL axis [0.03%]
老年小鼠来源的气道上皮细胞通过MBD2-sICOSL轴促进哮喘小鼠Th17细胞分化
Zhifeng Chen,Yulin Shang,Yu Yuan et al.
Zhifeng Chen et al.
Th17 cells are involved in the pathogenesis of elderly asthma. Bronchial epithelial cells (BECs) can act as antigen-presenting cells, and our previous studies have shown that methyl-CPG binding domain protein 2 (MBD2) in BECs can promote Th...
Hyperoside suppresses NSCLC progression by inducing ATG13-mediated autophagy and apoptosis [0.03%]
hyperoside通过诱导ATG13介导的自噬和凋亡来抑制非小细胞肺癌进展
Mingming Jin,Yuqing Lou,Xiaoshuo Wang et al.
Mingming Jin et al.
Background: Lung cancer is a leading cause for cancer-related mortality across the globe. In the last decade, significant advancements have been made in the research of non-small cell lung cancer (NSCLC). However, new bio...
Role of CD44+CCR2+CD64-monocyte-derived macrophage in chronic rhinosinusitis with nasal polyps [0.03%]
CD44+CCR2+CD64-单核细胞源性巨噬细胞在鼻息肉慢性鼻窦炎中的作用
Yuling Zhang,Mengzhe Yang,Yan Li et al.
Yuling Zhang et al.
Heterogeneity of monocyte-derived macrophages (MDMs) is gradually recognized in polyp tissue of chronic rhinosinusitis with nasal polyps (CRSwNP). However, the contributions of MDM subsets for sustaining inflammation remain unclear. This st...
Novel and effective tandem CD38 and CD19 targeting CAR-T cells inhibit hematological tumor immune escape [0.03%]
新颖有效的串联CD38和CD19靶向CAR-T细胞可抑制血液系统肿瘤免疫逃逸
Xiuying Liu,Yaru Feng,Zhiru Song et al.
Xiuying Liu et al.
Targeting CD19 with chimeric antigen receptor (CAR)-T cells is clinically effective, but tumor immune escape and tumor recurrence still occur. Designing CAR-T cells that target multiple antigens simultaneously is a viable approach for inhib...
MAPK14 drives Ferroptosis and immune dysfunction in pediatric Sepsis-induced acute lung injury [0.03%]
MAPK14驱动儿童脓毒症急性肺损伤中铁死亡和免疫功能障碍
Ning Zhang,Yuanyuan Fan,Juan Chen et al.
Ning Zhang et al.
Objective: Sepsis-induced acute lung injury (ALI) is driven by inflammation, oxidative stress, and immune suppression. MAPK14 (p38α) plays a role in ferroptosis and immune regulation, but its specific function in pediatr...