Yixuan Ma,Yue Zhou,Miao Yu
Yixuan Ma
T follicular helper (Tfh) cells constitute a functionally specialized subset of CD4+ T lymphocytes that orchestrate germinal center (GC) responses, critically regulating B cell destination and the development of long-term humoral immunity. ...
Exosomes from hypoxic pretreated BMSCs attenuate primary Sjögren's syndrome-induced skin injury via PPARγ-mediated M2-like macrophage activation [0.03%]
缺氧预处理的BMSCs源外泌体通过PPARγ介导的M2型巨噬细胞活化缓解原发性舍格伦综合征所致皮肤损伤
Xin Wang,Xu Sun,Xinmeng Yang et al.
Xin Wang et al.
Background: Sjögren's syndrome (SS) is an autoimmune disorder identified by a triad of sicca symptoms, pain, and fatigue. SS-induced skin injury seriously affects people's health but remains unsolved. Accumulating invest...
EGCG remodels the TGF-β cervical cancer micro-environment towards immune responsiveness [0.03%]
EGCG通过重塑人宫颈癌微环境的免疫抑制作用向免疫反应性转变
Jayapradha Gnanagurusamy,Rajalakshmi Sabanayagam,Sneha Krishnamoorthy et al.
Jayapradha Gnanagurusamy et al.
Background: Exploring the role of immune modulators alongside TGF-β in cervical cancer (CC) and PBMCs may improve the understanding of targeted treatment strategies. ...
Exploring novel strategies of oncolytic viruses and gut microbiota to enhance CAR-T cell therapy for colorectal cancer [0.03%]
探究溶瘤病毒和肠道微生物的新策略以增强CAR-T细胞疗法治疗结直肠癌的效果
Jia Yi,Sangmu Quji,Luxuan Guo et al.
Jia Yi et al.
Colorectal cancer (CRC), ranking as the third most prevalent malignant tumor globally (accounting for 10.0 % of new cancer cases) and the second leading cause of cancer-related deaths (9.4 % of cancer mortality), continues to escalate in in...
Mohua Liu,Xiao Wang,Xiaoya Qu et al.
Mohua Liu et al.
Both trained immunity (TRIM) and endotoxin tolerance (ET) initiate similar metabolic reprogramming characterized by enhanced glycolysis following an initial stimulus. However, TRIM exhibited heightened immune activation upon restimulation, ...
A synergy of CD133 overexpression and TGF-β supplementation in tumorigenesis of ovarian cancer cell lines in a three-dimensional sphere forming model [0.03%]
CD133过表达与TGF-β补充协同促进卵巢癌细胞系三维类器官模型中肿瘤发生发展
Hao-Chien Hung,Tsui-Lien Mao,Ke-Hung Tsui et al.
Hao-Chien Hung et al.
Background: Ovarian cancer (OC) is a highly lethal gynecological malignancy, mainly due to chemoresistance and tumor recurrence. Cancer stem cells (CSCs) may be responsible for chemoresistance, and CSC has become a new ta...
Establishment of a multi-parameter flow cytometry method to identify and characterize neutrophil extracellular traps [0.03%]
建立一种鉴定和表征中性粒细胞胞外陷阱的多功能流式细胞术方法
Weixiang Liu,Jieming Ping,Ning Wu
Weixiang Liu
Neutrophil extracellular traps (NETs) are web-like decondensed DNA filaments released by activated neutrophils, decorated with antimicrobial proteins such as myeloperoxidase (MPO) and elastase. Although several methods exist to evaluate NET...
Establishing a clinical prediction model of neurosyphilis via a lumbar-puncture-free nomogram [0.03%]
基于腰穿的神经梅毒临床预测模型的建立及验证：简易神经梅毒诊断计分卡的构建
Xuebi Wang,Wei Wang,Yabin Liu et al.
Xuebi Wang et al.
Objectives: Neurosyphilis (NS) can cause a range of central nervous system (CNS) damage, from asymptomatic states to severe mental disorders. While lumbar puncture is a reliable diagnostic method for NS, it is often poorl...
ANAPC5 mitigates acute lung injury through regulating macrophage M1/M2 polarization via the EGFR/CD24 axis [0.03%]
ANAPC5通过EGFR/CD24轴调节巨噬细胞M1/M2极化来缓解急性肺损伤
Yiqi Wang,Xiuhua Zhang,Jiannan Zhang et al.
Yiqi Wang et al.
Acute lung injury (ALI) is a respiratory disease induced by uncontrolled inflammatory responses in the lungs. The pathological features of ALI include alveolar structural damage and pulmonary edema, which ultimately leads to pulmonary dysfu...
METTL3 positively regulates the development and cytotoxicity of human embryonic stem cells-derived NK cells [0.03%]
METTL3正向调节人胚胎干细胞来源的NK细胞的发育和细胞毒性
Xiaofeng Yin,Zhaohui Zhang,Jiaxing Qiu et al.
Xiaofeng Yin et al.
Human embryonic stem cell-derived NK (hESC-NK) cells or induced pluripotent stem cell derived NK cells have demonstrated efficacy and safety in clinical trials for cancer therapy and serve as a valuable tool for studying the mechanisms of h...