METTL3 positively regulates the development and cytotoxicity of human embryonic stem cells-derived NK cells [0.03%]
METTL3正向调节人胚胎干细胞来源的NK细胞的发育和细胞毒性
Xiaofeng Yin,Zhaohui Zhang,Jiaxing Qiu et al.
Xiaofeng Yin et al.
Human embryonic stem cell-derived NK (hESC-NK) cells or induced pluripotent stem cell derived NK cells have demonstrated efficacy and safety in clinical trials for cancer therapy and serve as a valuable tool for studying the mechanisms of h...
Identification of Epstein-Barr virus nuclear antigen 1 (EBNA1)-specific T-cell receptors: implications for immunotherapy targeting EBV-associated malignancies [0.03%]
识别针对Epstein-Barr病毒核抗原1（EBNA1）的特异性T细胞受体：对靶向EB病毒相关恶性肿瘤免疫治疗的意义
Ying Liu,Yaqi Pan,Huirong Ding et al.
Ying Liu et al.
Background: Epstein-Barr virus nuclear antigen (EBNA1) is uniquely expressed across all three EBV latency types, making it an ideal target for TCR-engineered T-cell therapy against EBV-associated malignancies. However, pr...
Chloroquine treatment ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell differentiation and pDC accumulation [0.03%]
氯喹通过抑制T细胞分化和pDC聚集来改善实验性自身免疫性脑脊髓炎
Yonghai Li,Yue Shao,Xianfen Ma et al.
Yonghai Li et al.
Objectives: Chloroquine (CQ) has been used to treat rheumatoid arthritis and systemic lupus erythematosus, but its use in multiple sclerosis (MS) is limited by side effects and insufficient efficacy. To enhance treatment ...
Sfrp2-deficient colonic fibroblasts drive mucosal inflammation and epithelial injury in ulcerative colitis [0.03%]
肠炎相关无Sfrp2成纤维细胞驱动黏膜炎症和上皮损伤
Mengyuan Zhu,Zhanqiu Diao,Lei Hu et al.
Mengyuan Zhu et al.
Ulcerative colitis (UC) is a chronic inflammatory disorder targeting the colon, which remains clinically challenging due to limited targeted therapies. Although intestinal fibroblasts have emerged as critical regulators of mucosal immunity ...
Enhancing the antitumor activity of CD19/BCMA CAR-T cells in vitro with a PD1IL7R chimeric switch receptor [0.03%]
通过PD1-IL7R嵌合开关受体提高CD19/BCMA CAR-T细胞的体外抗肿瘤活性
Kai Yan,Zhongdang Xiao
Kai Yan
Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of hematologic malignancies, but its long-term efficacy is hindered by antigen escape, T-cell exhaustion, and the immunosuppressive tumor microenvironment (TME)...
Acetyl-CoA subcellular compartmentalization regulates T cell adaptation [0.03%]
乙酰辅酶A亚细胞区隔化调节T细胞适应性反应
Annefien Tiggeler,Paul J Coffer
Annefien Tiggeler
Upon activation, naïve T cells undergo rapid proliferation and differentiation, giving rise to clonally expanded populations specifically tailored for an effective immune response. To meet the heightened bioenergetic and biosynthetic deman...
Functional avidity enhancement of a T-cell receptor targeting the KRASG12D cancer neoantigen [0.03%]
靶向KRASG12D癌症新抗原的T细胞受体的功能亲和力增强
Feiyang Luo,Qiwen Yao,Yanan Hao et al.
Feiyang Luo et al.
Engineered T cell receptors (TCRs) targeting neoantigens represent a transformative approach in cancer immunotherapy, yet their clinical potential is limited by low natural TCR avidity and the risk of off-target toxicity from over-engineere...
M6A methyltransferase ZC3H13-mediated downregulation of GPX4 mRNA stability inhibits the progression of kidney renal clear cell carcinoma (KIRC) [0.03%]
ZC3H13甲基转移酶介导的GPX4 mRNA稳定性下调抑制肾透明细胞癌的发展进展
Dongli Ruan,Rui Huang,Huilong Wang et al.
Dongli Ruan et al.
Background: Kidney renal clear cell carcinoma (KIRC) is one of the fatal genitourinary diseases and accounts for most malignant kidney tumors. Previous studies have indicated that RNA modification N6-methyladenosine zinc-...
Quercetin alleviates diabetic nephropathy by inhibiting M1 macrophage polarization via targeting NLRC5/NLRP3 pathway [0.03%]
染料木素通过靶向NLRC5/NLRP3信号途径抑制M1型巨噬细胞活化从而改善糖尿病肾病
Abudoushalamu Abudoureyimu,Chen Chen,Yan Hu et al.
Abudoushalamu Abudoureyimu et al.
Background: The activation imbalance of M1/M2 macrophage phenotypes is crucial in diabetic nephropathy (DN). This study aimed to explore the molecular mechanisms underlying quercetin's action against DN. ...
Efficacy and safety of interferon alpha-2b aerosol therapy for patients infected with the SARS-CoV-2 omicron variant: A randomized controlled single-blind study [0.03%]
干扰素α-2b气溶胶治疗奥密克戎变异株感染患者的疗效和安全性：单盲随机对照试验
Yinpeng Jin,Xianming Meng,Zhiping Qian et al.
Yinpeng Jin et al.
The efficacy of Type I interferon (IFN) in treating COVID-19 has remained controversial. In this study, we conducted a randomized, single-blind clinical trial to evaluate the efficacy of recombinant human interferon alpha 2b (IFN-alpha2b) i...