The paracrine immunomodulatory interactions between the human dental pulp derived mesenchymal stem cells and CD4 T cell subsets [0.03%]
人牙髓来源间充质干细胞与CD4T细胞亚群旁分泌免疫调节相互作用
Alper Tunga Özdemir,Rabia Bilge Özgül Özdemir,Cengiz Kırmaz et al.
Alper Tunga Özdemir et al.
Mesenchymal stem cells (MSCs) have strong immunomodulatory properties, however these properties may show some differences according to the tissue type of their isolate. In this study we investigated the paracrine interactions between human ...
Improvement of anti-tumor immunity of fibroblast activation protein α based vaccines by combination with cyclophosphamide in a murine model of breast cancer [0.03%]
Cyclophosphamide联合纤维激活蛋白α疫苗可改善乳腺癌小鼠模型的抗肿瘤免疫效应
Qiu Xia,Fang-Fang Zhang,Fei Geng et al.
Qiu Xia et al.
Fibroblast activation protein α (FAPα) is expressed in cancer-associated fibroblasts (CAFs), which are the main type of cells in the tumor microenvironment. CAFs exert immunosuppressive activity, which can weaken the effects of cancer imm...
Role of Wnt3a expressed by dendritic cells in the activation of canonical Wnt signaling and generation of memory T cells during primary immune responses [0.03%]
树突状细胞表达的Wnt3a在初始免疫反应中活化经典Wnt信号通路和生成记忆T细胞中的作用
Lei Luo,Zhengyu Li,Guangheng Luo et al.
Lei Luo et al.
The presence of memory T cells (TMs) hinders transplant survival. Dendritic cells (DCs) induce the generation of TMs during primary immune responses. However, the specific mechanisms are unclear. In this study, we constructed a Wnt3a-expres...
The impact of P2X7 receptor antagonist, brilliant blue G on graft-versus-host disease in mice after allogeneic hematopoietic stem cell transplantation [0.03%]
Brilliant蓝G对异基因造血干细胞移植小鼠移植物抗宿主病P2X7受体的影响
Xiaomin Zhong,Feng Zhu,Jianlin Qiao et al.
Xiaomin Zhong et al.
The purpose of this study was to investigate the role of P2X7 on liver inflammation in mice after HSCT. Hematopoietic stem cells obtained from C57BL/6 mice were administrated into BALB/c mice to establish GVHD model. On day 7, 14, 21 and 28...
Leishmania, the phagosome, and host responses: The journey of a parasite [0.03%]
利什曼原虫、吞噬体和宿主反应：寄生虫的旅程
Olivier Séguin,Albert Descoteaux
Olivier Séguin
Leishmania is the eukaryotic parasite responsible for leishmaniases, a spectrum of diseases that puts at risk roughly 350millions of people in 98 countries according to the Drugs for Neglected Diseases initiative (DNDi). This parasite has a...
Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes [0.03%]
刺猬信号调节癌细胞中的PDL-1表达以诱导活化淋巴细胞的抗肿瘤活性
Hideya Onishi,Akiko Fujimura,Yasuhiro Oyama et al.
Hideya Onishi et al.
We investigated whether hypoxia-induced activation of Hh signaling contributes to PDL-1 expression in cancer and whether it affects the anti-tumor function of activated lymphocytes. Hypoxia augmented PDL-1 expression and inhibition of Hh si...
Immunotherapeutic strategies for sexually transmitted viral infections: HIV, HSV and HPV [0.03%]
针对性传播病毒的免疫治疗策略：艾滋病、单纯疱疹和人乳头瘤病毒感染
Braira Wahid,Amjad Ali,Muhammad Idrees et al.
Braira Wahid et al.
More than 1 million sexually transmitted infections (STIs) are acquired each day globally. Etiotropic drugs cannot effectively control infectious diseases therefore, there is a dire need to explore alternative strategies especially those ba...
Phosphatidylcholine as a metabolic cue for determining B cell fate and function [0.03%]
磷脂酰胆碱作为确定B细胞命运和功能的代谢信号分子
Joseph W Brewer,Viktoriya Solodushko,Ileana Aragon et al.
Joseph W Brewer et al.
In activated B cells, increased production of phosphatidylcholine (PtdCho), the most abundant cellular phospholipid, is handled primarily by the CDP-choline pathway. B cell-specific deletion of CTP:phosphocholine cytidylyltransferase α (CC...
Culture supernatants of cervical cancer cells induce an M2 phenotypic profile in THP-1 macrophages [0.03%]
宫颈癌细胞培养上清诱导THP-1单核细胞向M2型分化
Eliza Julia Pedraza-Brindis,Karina Sánchez-Reyes,Georgina Hernández-Flores et al.
Eliza Julia Pedraza-Brindis et al.
Patients with cervical cancer (CxCa) typically present an infiltrate of tumor-associated macrophages, which is associated with a poor prognosis. We found that CxCa cell lines (HeLa, SiHa, and C-33A) secreted factors involved in regulating t...
Leishmania exosomes and other virulence factors: Impact on innate immune response and macrophage functions [0.03%]
利什曼氏体外泌体及其他致病因素对先天性免疫反应和巨噬细胞功能的影响
Vanessa Diniz Atayde,Kasra Hassani,Alonso da Silva Lira Filho et al.
Vanessa Diniz Atayde et al.
Leishmania parasites are the causative agents of the leishmaniases, a collection of vector-borne diseases that range from simple cutaneous to fatal visceral forms. Employing potent immune modulation mechanisms, Leishmania is able to render ...