Droplet digital PCR quantifies host inflammatory transcripts in feces reliably and reproducibly [0.03%]
数字微滴PCR可可靠且重复地量化粪便中的宿主炎症转录物
Jennifer Stauber,Nurmohammad Shaikh,M Isabel Ordiz et al.
Jennifer Stauber et al.
The gut is the most extensive, interactive, and complex interface between the human host and the environment and therefore a critical site of immunological activity. Non-invasive methods to assess the host response in this organ are current...
Comparative Study
Cellular immunology. 2016 May:303:43-9. DOI:10.1016/j.cellimm.2016.03.007 2016
M1 macrophage infiltrations and histological changes in the liver after portal vein embolization using fibrinogen and OK432 in the rat [0.03%]
大鼠经门静脉栓塞后肝脏M1型巨噬细胞浸润及组织学变化
Tetsu Sato,Shigeru Marubashi,Akira Kenjo et al.
Tetsu Sato et al.
The mechanism of anti-tumor effect of transarterial Immuno-Embolization (TIE) using OK-432 has not been well elucidated. In this study, we aimed to investigate the tissue injury and immune response after portal venous embolization (PVE) wit...
Interleukin-21 administration leads to enhanced antigen-specific T cell responses and natural killer cells in HIV-1 vaccinated mice [0.03%]
IL-21能够增强HIV-1疫苗接种小鼠的特异性T细胞和自然杀伤细胞反应
Bin Ju,Dan Li,Xiaolin Ji et al.
Bin Ju et al.
Interleukin-21 (IL-21), which belongs to IL-2 γ chain receptor cytokine family, is as an important regulator of immune responses. In this study, we developed a novel strategy for immunizing mice with a DNA/vaccinia/protein vaccine in the p...
Isolation of vascular smooth muscle antigen-reactive CD4(+)αβTh1 clones that induce pulmonary vasculitis in MRL/Mp-Fas(+/+) mice [0.03%]
从MRL/mp-fasl/+小鼠中分离出血管平滑肌抗原反应性CD4+αβTh1克隆可诱发肺血管炎
Yoshimasa Fujita,Takao Fujii,Hironori Shimizu et al.
Yoshimasa Fujita et al.
Here, we established CD4(+)αβTh1 clones specific for rat vascular smooth muscle antigen (VSMAg) that induced vasculitis lesions in the lungs of MRL/Mp-Fas(+/+) mice following adoptive transfer. Six different T cell clones, MV1b1 (Vβ1), M...
Long-term allergen exposure induces adipose tissue inflammation and circulatory system injury [0.03%]
长期过敏原暴露诱导脂肪组织炎症和循环系统损伤
Chien-Cheng Jung,Huey-Jen Su
Chien-Cheng Jung
The purpose of this study was to study whether allergen exposure can induce inflammation and lower the anti-inflammation levels in serum and in adipose tissues, and further develop cardiovascular injury. Our data showed that heart rate was ...
The novel anti-CD19 chimeric antigen receptors with humanized scFv (single-chain variable fragment) trigger leukemia cell killing [0.03%]
一种新型的带有人性化单链可变区片段的抗CD19嵌合抗原受体能触发对白血病细胞的杀伤作用
Liren Qian,Dan Li,Lie Ma et al.
Liren Qian et al.
The molecular design of CARs (Chimeric Antigen Receptors), especially the scFv, has been a major part to use of CAR-T cells for targeted adoptive immunotherapy. To address this issue, we chose a vector backbone encoding a second-generation ...
Skewing of peritoneal resident macrophages toward M1-like is involved in enhancement of inflammatory responses induced by secondary necrotic neutrophils in aged mice [0.03%]
腹腔固有巨噬细胞向M1表型偏移参与了老年小鼠二次坏死中性粒细胞诱导的炎性反应增强现象
Rei Takahashi,Akihito Ishigami,Yoshiro Kobayashi et al.
Rei Takahashi et al.
Secondary necrotic cells, which are generated if apoptotic cells are incompletely cleared, induce severe inflammatory responses involving MIP-2 production and subsequent neutrophil infiltration. Recently, we showed that the phagocytic capac...
Mononuclear phagocyte accumulates a stearic acid derivative during differentiation into macrophages. Effects of stearic acid on macrophage differentiation and Mycobacterium tuberculosis control [0.03%]
单核吞噬细胞在分化为巨噬细胞过程中累积一种棕榈酸衍生物及这种脂肪酸对巨噬细胞分化和抗结核分枝杆菌感染的影响
Sergio Fabián Mosquera-Restrepo,Ana Cecilia Caro,Carlos Alberto Peláez-Jaramillo et al.
Sergio Fabián Mosquera-Restrepo et al.
The fatty acid composition of monocytes changes substantially during differentiation into macrophages, increasing the proportion of saturated fatty acids. These changes prompted us to investigate whether fatty acid accumulation in the extra...
David W Scott
David W Scott
Strategies to target long-lived plasma cells for treating hemophilia A inhibitors [0.03%]
针对A型血友病抑制物的长效浆细胞治疗策略
Chao Lien Liu,Meghan J Lyle,Simon C Shin et al.
Chao Lien Liu et al.
Long-lived plasma cells (LLPCs) can persistently produce anti-factor VIII (FVIII) antibodies which disrupt therapeutic effect of FVIII in hemophilia A patients with inhibitors. The migration of plasma cells to BM where they become LLPCs is ...