Drug screening identifies pyrrolidinedithiocarbamate ammonium ameliorating DSS-induced mouse ulcerative colitis via suppressing Th17 differentiation [0.03%]
药物筛选发现盐酸氨苯喋啶通过抑制Th17细胞分化改善DSS诱导的结肠炎
Yu-E Guo,Jie Lv,Ping Shu et al.
Yu-E Guo et al.
T helper 17 (Th17) cells play crucial roles in various autoimmune diseases, including ulcerative colitis (UC), which is characterized by widespread inflammation in the mucosa of the colon and rectum. To identify small-molecule compounds cap...
B cell-intrinsic IFN-γ promotes excessive CD11c+ age-associated B cell differentiation and compromised germinal center selection in lupus mice [0.03%]
狼疮小鼠的B细胞固有IFN-γ促进CD11c+衰老相关B细胞分化并导致生发中心反应受损
Shujun Liu,Wenqian Zhang,Shihao Tian et al.
Shujun Liu et al.
CD11c+ age-associated B cells (ABCs) have emerged as a key component in protective and autoreactive B cell responses. Lupus is an autoimmune disorder linked to reduced efficacy of vaccines and increased susceptibility to infections. Previou...
Complement system component 3 deficiency modulates the phenotypic profile of murine macrophages [0.03%]
补体系统成分C3缺陷可调节小鼠巨噬细胞表型谱型
Tiago Francisco da Silva,Thaís Akemi Amamura,Iuri Cordeiro Valadão et al.
Tiago Francisco da Silva et al.
The Complement System is composed of more than 40 proteins that act in innate and adaptive immunity. C3 is the most abundant one and C3-deficient patients are more susceptible to recurrent and severe infections. Several studies have demonst...
Gastrodenol suppresses NLRP3/GSDMD mediated pyroptosis and ameliorates inflammatory diseases [0.03%]
gastrodenol通过抑制NLRP3/GSDMD介导的细胞焦亡从而改善炎症疾病
Peipei Chen,Yunshu Wang,Huaiping Tang et al.
Peipei Chen et al.
Pyroptosis, a form of inflammatory programmed cell death, plays a pivotal role in the pathogenesis of various diseases. This process is primarily mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-co...
IL-10: A Key Regulator and potential therapeutic target in uveitis [0.03%]
白细胞介素10(IL-10)在葡萄膜炎中扮演的重要调节角色及其作为潜在治疗靶点的作用机制研究进展
Chengzhi Liu,Xinyu Wang,Xusheng Cao
Chengzhi Liu
Uveitis is a prevalent inflammatory eye disease that primarily affects working-age individuals and can lead to blindness if untreated. Interleukin-10 (IL-10) is a multifunctional cytokine with broad immunosuppressive properties and plays a ...
House dust mite allergen directly activates ILC2 cells via the TLR4 signaling pathway in allergic airway diseases [0.03%]
house dust mite allergen通过TLR4信号通路直接激活ILC2细胞在过敏性气道疾病中
Yan Li,Zhennan Qu,Xue Wang et al.
Yan Li et al.
Background: Unlike T cells and B cells, the activation process of group 2 innate lymphoid cells (ILC2s) is mainly driven by epithelial cell derived cytokines rather than specific antigen recognition. Whether antigens have...
Mike Telemaco Contreras Colmenares,Amanda de Oliveira Matos,Pedro Henrique Dos Santos Dantas et al.
Mike Telemaco Contreras Colmenares et al.
The Triggering Receptor Expressed on Myeloid cells 2 (TREM-2) has been widely known by its anti-inflammatory activity. It can be activated in response to microbes and tissue damage, leading to phagocytosis, autophagy, cell polarization and ...
Netosis and trained immunity in tick-borne diseases: a possible pathogenetic role [0.03%]
体外寄生虫病中的NETosis和训练免疫：可能的病理作用
Giusto Davide Badami,Bartolo Tamburini,Leila Mohammadnezhad et al.
Giusto Davide Badami et al.
Various types of pathogens transmitted by ticks elicit distinct immune responses just like the emerging α-Gal syndrome that is associated with allergic reactions to tick bites. The mechanisms of Neutrophil Extracellular Traps release (call...
Embracing multiple infection models to tackle Q fever: A review of in vitro, in vivo, and lung ex vivo models [0.03%]
兼收并蓄立克次体热(Q热)感染模型以应对Q热：体外、体内及肺组织切片模型综述
R Marena Guzman,Daniel E Voth
R Marena Guzman
Multiple animal and cell culture models are employed to study pathogenesis of Coxiella burnetii, the causative agent of acute and chronic human Q fever. C. burnetii is a lung pathogen that is aerosolized in contaminated products and inhaled...
Evaluation of TNF-α and IFN-γ primed conditioned medium of mesenchymal stem cell in acetic acid-induced mouse model of acute colitis [0.03%]
评估细胞因子TNF-α和IFN-γ预处理的间充质干细胞条件培养基在醋酸诱导的小鼠急性结肠炎模型中的作用
Manizhe Faghih,Mona Moshiri,Nader Mazrouei Arani et al.
Manizhe Faghih et al.
IBD, an autoimmune-inflammatory disorder that affects people who are genetically prone to inflammation. There is a lot of interest in MSC-CM therapy, especially when primed with TNF-α + IFN-γ. Throughout the study, data were collected on ...