Monocyte abundance and glycolytic reprogramming associate with motivational impairment in depression [0.03%]
单核细胞丰度和糖酵解重编程与抑郁障碍患者的动机损害相关性研究
Mandakh Bekhbat,Genevieve Craig,Evanthia C Wommack et al.
Mandakh Bekhbat et al.
Inflammation and altered glucose metabolism are implicated in motivational anhedonia, a core feature of major depression (MD) that is sensitive to energy homeostasis. We previously reported preliminary evidence that MD with elevated inflamm...
STK40 contributes to neuropathic pain by modulating macrophagic glycogen metabolism and inflammatory responses through the AKT/GSK3β/GYS1 axis [0.03%]
STK40通过AKT/GSK3β/GYS1轴调节巨噬细胞糖原代谢和炎症反应，从而参与神经病理性疼痛发生发展
Youjia Fan,Muqiu Xu,Ting Liu et al.
Youjia Fan et al.
Neuropathic pain (NP) is a complex and debilitating condition characterized by persistent pain due to nerve injury, underscoring the urgent need for improved diagnostic and treatment strategies. Although the glycogen metabolic process (GMP)...
Ventral striatal neuroimmune signalling biases the expression of social memory in male mice [0.03%]
雄性小鼠腹侧纹状体神经免疫信号传导偏向社交记忆的表达
M Rinaudo,S Autelitano,C D&#x;Amelio et al.
M Rinaudo et al.
Social behaviours are highly sensitive to inflammatory states. However, the precise contribution of neuroinflammation in the ventral striatum to social memory remains unclear. Using a mouse model of recurrent herpes simplex virus-1 (HSV-1) ...
Early-life musical intervention programs neuroimmune activity and synaptic plasticity to enhance adult learning and memory [0.03%]
生命早期的音乐干预项目可以增强神经免疫活性和突触可塑性以增进成人学习能力和记忆能力
Rui Qiu,Qiang Fu,Tongtong Yao et al.
Rui Qiu et al.
Early-life sensory environments can shape lifelong brain function, yet the neuroimmune and neuroplastic mechanisms through which musical stimulation influences cognitive development remain poorly understood. Here, we examined how graded mus...
Mild exogenous inflammation reduces dynamic small-world topology in resting-state brain networks of healthy males [0.03%]
轻度外源性炎症会减少健康男性静息态脑网络的动态小世界拓扑性质
Filippo Queirazza,Rajeev Krishnadas
Filippo Queirazza
Systemic inflammation is increasingly recognised as a key modulator of brain function, yet its impact on large-scale brain network topology remains incompletely understood. In particular, it is unclear whether inflammation alters the balanc...
Pre-injury hypercholesterolemia is associated with microbiota-associated neurobehavioral vulnerability following traumatic brain injury [0.03%]
创伤性脑损伤前的高胆固醇与微生物群相关的神经行为脆弱性有关
Guan-Yu Chen,Hsiao-Yue Wee,Min-Hsi Chiu et al.
Guan-Yu Chen et al.
Traumatic brain injury (TBI) is increasingly recognized as a systemic disorder associated with long-term neuropsychiatric sequelae. However, substantial inter-individual variability suggests that pre-injury metabolic status may influence ne...
Complement component C4 and neuroimaging in psychiatry: A systematic review [0.03%]
补体成分C4和精神病的影像学：系统性综述
Chabert Jonathan,Laidi Charles,Caseras Xavier et al.
Chabert Jonathan et al.
Introduction: Genomic, transcriptomic, and proteomic studies suggest that the complement system contributes to the pathophysiology of various psychiatric disorders partly through neurodevelopmental effects linked to C4A p...
Inflammatory protein markers and treatment outcomes across mood and psychotic disorders: a systematic review and meta-analysis [0.03%]
精神和精神病障碍患者的炎症蛋白标志物及其治疗效果的系统评价和meta分析
Chiara Possidente,Arianna Biancalani,Bernhard T Baune et al.
Chiara Possidente et al.
Poor treatment outcomes worsen prognosis in schizophrenia, bipolar disorder (BD), and major depressive disorder (MDD) and likely involve shared mechanisms, including alterations in inflammatory protein markers. However, the role of these ma...
Astrocytes exploit a neutrophil extracellular trap - like mechanism for myelin management: A new perspective on myelin-related disorders [0.03%]
astrocyte 利用类似中性粒细胞胞外陷阱的方式进行髓鞘管理：髓鞘相关疾病的新视角
Marina G Yefimova,Anne Cantereau-Becq,Noémie Pénaud et al.
Marina G Yefimova et al.
The canonical innate immune functions of astrocytes play a critical role in maintaining CNS homeostasis, including myelin remodeling - a physiological process that unfolds throughout life. Elimination of aged myelin and myelin debris is nec...
Pro-inflammatory markers interact with spontaneous theta oscillations to predict depression among adolescents [0.03%]
炎症标志物通过与自发theta振荡相互作用预测青少年抑郁症状
Mikki Schantell,Nayoung Kim,Esha Trivedi et al.
Mikki Schantell et al.
Adolescence is a period of heightened neuroimmune plasticity, during which inflammatory activity may be associated with neural processes relevant to depression risk. To obtain a range of symptoms, adolescents (N = 182; 13-18-years-old) were...