NR2B-CaMKII signaling in the dentate gyrus driven by astrocytic P2Y1Rs mediates the antidepressant effect of low-dose LPS [0.03%]
低剂量内毒素的抗抑郁效应依赖于星形胶质细胞P2Y1R介导海马齿状回NR2B-CaMKII信号通路
Minxiu Ye,Chao Huang,Yiming Gu et al.
Minxiu Ye et al.
Microglial decline in the dentate gyrus is an important mechanism in the development of depression-like behaviors in stressed animals. Reversing this decline with low-dose lipopolysaccharide (LPS) can produce rapid antidepressant effects, y...
Early life stress in mice disrupts blood-brain barrier function and reduces claudin-5 expression in the lateral septum and striatum, with linked behavioral impairments [0.03%]
小鼠早期生活压力可破坏血脑屏障功能并降低侧隔核和纹状体中闭锁素-5的表达，伴随行为损伤
Danina Evertse,Ella L Sommer,Nicky Markus et al.
Danina Evertse et al.
Early life stress (ELS) has been implicated in blood-brain barrier (BBB) dysfunction, yet its long-term behavioral consequences remain poorly understood. Here, we found that limited bedding and nesting (LBN) in mice from postnatal day (P) 2...
Central nervous system-penetrant anti-C1q therapy reduces neuroinflammation and preserves neurological function in a model of progressive multiple sclerosis [0.03%]
能够穿过中枢神经系统的抗C1q疗法减少炎症并保存进行性多发性硬化模型中的神经系统功能
Michael Linzey,Steven C Pike,Nour-Maria Bouzid et al.
Michael Linzey et al.
Multiple sclerosis (MS) is a chronic, immune-mediated disease of the central nervous system (CNS) characterized by both neuroinflammation and neurodegeneration. While significant progress has been made in the treatment of relapsing-remittin...
Dopaminergic modulation of NK cell maturation and immune-associated social behavior in a 15q dup mouse model [0.03%]
多巴胺调节15q重复小鼠模型中自然杀伤细胞成熟及免疫相关社交行为
Xinran Chen,Xiangyan Zhang,Jin Feng et al.
Xinran Chen et al.
Autism spectrum disorder (ASD) is a neurodevelopmental condition frequently associated with immune dysregulation, yet the mechanistic basis of this comorbidity remains poorly understood. Using the paternal 15q11-13 duplication (15q dup) mou...
The role of NLRP3 inflammasome in opioid-induced neurochemical markers, therapeutic effects, and adverse effects in male mice [0.03%]
NLRP3炎症小体在阿片类药物诱导的神经化学标志物、治疗效果及不良反应中的作用：雄性小鼠模型研究
Myosotys Rodriguez,Dileepkumar Veeragoni,Candy Carbajal et al.
Myosotys Rodriguez et al.
Repeated administration of opioids such as morphine and fentanyl activates glial cells, leading to the release of pro-inflammatory molecules through secretory pathways, including theNLRP3 inflammasome. NLRP3 activation is thought to contrib...
Systemic inflammation and dorsolateral striatal activity converge to drive repetitive and compulsive-like behaviors caused by chronic stress [0.03%]
慢性压力所致重复行为和类似强迫症行为的产生是系统性炎症与背外侧纹状体活动相互作用的结果
Che-Chuan Wang,Sheng-Feng Sung,Chih-Hua Chang et al.
Che-Chuan Wang et al.
Repetitive and compulsive-like behaviors, characterized by excessive repetition and rigidity, are a key feature of many psychiatric and neurodevelopmental disorders. However, how chronic stress triggers these maladaptive behaviors and the u...
Physical exercise modulates T cell activity and mitigates synaptic dysfunction in multiple sclerosis through vagus nerve engagement [0.03%]
锻炼通过迷走神经刺激调节T细胞活性并缓解多发性硬化症的突触功能障碍
Alessandra Musella,Sara Balletta,Claudia Russo et al.
Alessandra Musella et al.
Physical exercise (PE) exerts beneficial effects in people with multiple sclerosis (pwMS). Preclinical studies in mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS, indicate that PE may attenuate key pathologi...
Interleukin-1 receptor-1 signaling mediates neuroinflammation, neuronal injury, and cognitive decline after diffuse traumatic brain injury [0.03%]
白细胞介素-1受体1信号通路在弥漫性创伤性脑损伤后介导神经炎症、神经元损伤和认知功能下降中的作用
Amara C Davis,Ethan J Goodman,Lynde M Wangler et al.
Amara C Davis et al.
Traumatic brain injury (TBI) increases the risk of developing neuropsychiatric illness and cognitive impairment. Previous work indicates that inflammatory pathways associated with interleukin (IL)-1 and interferon signaling persist in the b...
Corrigendum to "The paradoxical protective effect of chronic stress on advanced Alzheimer's disease pathology". [Brain, Behav., Immun. 132 (2026) 106224] [0.03%]
关于“慢性压力对晚期阿尔茨海默病病理学的保护作用悖论”的勘误[《脑、行为和免疫》132 (2026) 106224]
Yoel Shor,Reut Said,Nina Fainstein et al.
Yoel Shor et al.
Published Erratum
Brain, behavior, and immunity. 2026 Mar 3:135:106519. DOI:10.1016/j.bbi.2026.106519 2026
Lnc-USP28-6/ZBTB16 axis orchestrates NLRP3 inflammasome activation and α-synuclein SUMOylation to drive Parkinson's disease pathogenesis [0.03%]
长非编码RNA USP28-6/ZBTB16轴通过调控NLRP3炎性小体活化和α-突触核蛋白SUMO化驱动帕金森病发病机制
Nan Wang,Man Wang,Yifei You et al.
Nan Wang et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by neuroinflammation and the aggregation of α-synuclein (α-syn), which lead to progressive neuronal loss, yet regulatory mechanisms remain elusive. Zinc finger and BTB...