Microglial PTP1B promotes synaptic pathology and cognitive deficits in chronic Toxoplasma gondii infection [0.03%]
慢性弓形虫感染中微胶质细胞PTP1B促进突触病理和认知缺陷
Daxiang Xu,Cheng He,Huiling Lv et al.
Daxiang Xu et al.
Chronic infection with the neurotropic pathogen Toxoplasma gondii has been epidemiologically associated with a risk of neurodegeneration; however, the mechanisms driving infection-associated cognitive decline remain unclear. We investigated...
Dynamics of the systemic inflammatory response surrounding stressors and the association with neuropsychiatric and somatic outcomes [0.03%]
应激源周围全身性炎症反应的动态变化及其与神经精神和躯体结局的关系
Rok Berlot,Ester Ipavic,Katharine Lynch-Kelly et al.
Rok Berlot et al.
Acute and chronic stressors contribute to neuropsychiatric disorders. However, the role of inflammatory dynamics around stress exposure remains unclear. Using TriNetX, an international electronic health records database, we examined how sys...
Omega-3 supplementation reduces perceived social isolation in a sex-dependent manner: secondary analysis of an RCT [0.03%]
ω-3补充剂以性别依赖的方式减少感知社会孤立——一项随机对照试验的二次分析结果
Annelise A Madison,Tatum A Jolink,Stephanie J Wilson et al.
Annelise A Madison et al.
Background: Loneliness and chronic inflammation create a vicious cycle, and females may be especially vulnerable. In these secondary analyses of an RCT, we investigated whether omega-3 (n-3) supplementation decreased lone...
Kynurenine pathway profiles as markers of ketamine response in treatment-resistant depression [0.03%]
氯胺酮抵抗型抑郁症治疗反应标志物——抗炎通路的生物标志物研究
Bruno Pedraz-Petrozzi,Marta Marszalek-Grabska,Emilia Fornal et al.
Bruno Pedraz-Petrozzi et al.
Treatment-resistant depression (TRD) remains a major clinical challenge, with highly variable responses to ketamine. Immune activation characterizes a subset of patients with TRD. The kynurenine pathway (KP), which integrates immunometaboli...
Microglial brain-derived neurotrophic factor (BDNF) supports the behavioral and synaptogenic effects of ketamine [0.03%]
小胶质细胞源脑源性神经营养因子(BDNF)支持氯胺酮的行为学及突触发生效应
Samuel C Woodburn,Alexander Kuhn,Kelly Bosis et al.
Samuel C Woodburn et al.
Ketamine promotes spine growth on the apical dendrites of pyramidal neurons in the prefrontal cortex (PFC), which are critical for its behavioral effects. Follow-up studies show that brain-derived neurotrophic factor (BDNF) signaling is cri...
Hippocampal C5a-C5aR1 axis drives age-related memory decline via collapsing synaptic chloride homeostasis [0.03%]
补体C5a-C5aR1轴通过破坏氯离子稳态驱动年龄相关记忆衰退
Wenying Liu,Wei Qin,Ying Li et al.
Wenying Liu et al.
The hippocampus is highly vulnerable to brain aging and associated neuroinflammation, a key factor compromising hippocampal plasticity. Specifically, the complement C5a-C5aR1 axis acts as a critical inflammatory convergence point known to i...
Bifidobacterium bifidum TMC3115-RAW264.7 cell conditioned mediums promote the synaptic development of primary hippocampal neuron via activating IL-6/JAK2/STAT3 signaling pathway [0.03%]
枯草芽孢杆菌TMC3115和 RAW264.7细胞条件培养基通过激活IL-6/JAK2 / STAT3信号通路促进原代海马神经元的突触发育
Wen Jia,Zhimo Zhou,Hongru Chen et al.
Wen Jia et al.
Immunomodulation represents a key mechanism through which the microbiota-gut-brain axis exerts its effects. While probiotics can promote central nervous system (CNS) development via this axis, current in vitro models hard to recapitulate th...
T cells contribute to approaching positive but potentially risky stimuli through medial prefrontal cortex immune modulation [0.03%]
中前额叶皮层免疫调节促进t细胞对积极但潜在有害刺激趋近式反应
Anna Panuccio,Juliette Gimenez,Marta Tiberi et al.
Anna Panuccio et al.
Avoidance behaviour, a core feature of the "Behavioural Immune System," minimizes exposure to pathogens but limits social and environmental engagement. For some individuals, the benefits of approaching attractive but risky stimuli may outwe...
Insulin modulates mPFC gene expression and emotional behavior in a sex-specific manner following fetal growth restriction [0.03%]
胰岛素以性别特异性方式调节胎儿生长限制后的mPFC基因表达和情感行为
Patrícia Maidana Miguel,Barbara Barth,Aashita Batra et al.
Patrícia Maidana Miguel et al.
Prenatal adversity, such as exposure to stress and malnutrition, increases lifelong vulnerability to neuropsychiatric and metabolic disorders, in part through long-lasting alterations in neuroendocrine and immune signaling that shape brain ...
Activation of the cGAS-STING pathway contributes to cancer-related fatigue in a murine model of head and neck cancer [0.03%]
cGAS-STING途径的激活会影响头颈部癌症小鼠模型中的癌因性疲劳症状
Brandon Chelette,Abate Bashaw,Joshua D Bryant et al.
Brandon Chelette et al.
Cancer-related inflammation and metabolic alterations extend beyond the tumor microenvironment, exerting systemic effects that disrupt energy homeostasis and contribute to reduced physical function and chronic fatigue. The cGAS-STING pathwa...