The acute phase inflammatory response as a key determinant of reduced lipid-associated antioxidant defenses in Chinese patients with major depressive disorder [0.03%]
在中国抑郁症患者中急性期炎症反应是脂质相关抗氧化防御降低的关键决定因素
Tangcong Chen,Mengqi Niu,Yueyang Luo et al.
Tangcong Chen et al.
Background: Major depressive disorder (MDD) is characterized by interacting neuro-immune, metabolic, and oxidative stress pathways. Here, we examine the interactions between the acute phase (AP) response and serum lipids ...
Probiotic supplementation as a strategy to counteract chronic hypoxia-related damages [0.03%]
益生菌补充作为对抗慢性缺氧相关损害的策略
Francesco Maria Grasselli,Laura Bonfili,Massimiliano Cuccioloni et al.
Francesco Maria Grasselli et al.
Chronic hypoxia plays a critical role in the pathogenesis of numerous diseases by triggering cellular and molecular adaptations that disrupt tissue homeostasis, impair gut eubiosis, promote inflammation, and contribute to progressive functi...
Late-pregnancy oxytocin alleviates neuroinflammation and hyperalgesia in chronic migraine model via PVN to NTS oxytocinergic projections and ECM-receptor interaction signaling [0.03%]
晚期妊娠催产素通过PVN到NTS的催产素能投射和ECM-受体相互作用信号减轻慢性偏头痛模型的神经炎症和高敏症
Lintao Wang,Ziming Zeng,Yanjie Zhou et al.
Lintao Wang et al.
Migraine is a primary neurological disorder characterized by recurrent episodes of headache. Clinical studies have shown that female migraine patients typically experience a significant reduction in headache severity and frequency during la...
Cerebral gray matter volumes in long-term post-COVID patients are associated with peripheral kynurenine pathway metabolites and the severity of depressive symptoms [0.03%]
长期COVID患者的脑灰质体积与外周犬尿氨酸代谢物及抑郁症状严重程度相关
Lynn Matits,Jana Schellenberg,Alexander Rau et al.
Lynn Matits et al.
Background: Structural brain changes and immune-metabolic alterations are widely reported in post-COVID condition (PCC), particularly among patients with depressive symptoms. Alterations in gray matter volume (GMV) and dy...
NRF2 ameliorates TBI-triggered Parkinsonism: synchronized antioxidant defense and neuroinflammation suppression [0.03%]
NRF2改善TBI触发的帕金森综合征：同步抗氧化防御和抑制神经炎症
Hao Cheng,Zhenze Liu,Rong Sha et al.
Hao Cheng et al.
Traumatic brain injury (TBI) confers long-term vulnerability to progressive neurological sequelae, including Parkinsonian-like symptoms. Impaired redox homeostasis and neuroinflammation may drive neurodegeneration post-TBI, while the pathol...
Brain-derived extracellular vesicle (BDEV) abundance and BDEV protein associations with clinical phenotypes and treatment response in untreated first-episode psychosis [0.03%]
首次发作未经治疗的精神病患者大脑源性胞外囊泡丰度及其蛋白质与临床表型和治疗反应的关系
Lusi Zhang,Adam M Lee,Zia L Maxim et al.
Lusi Zhang et al.
Reliable biomarkers that capture central nervous system (CNS) processes during the earliest stages of psychosis are critically needed to improve early treatment and response monitoring. Brain-derived extracellular vesicles (BDEVs) that trav...
A longitudinal examination of gut microbiota dysbiosis and neuro-behavioral phenotypes of poly(I:C)-maternal immune activation in a preclinical model of autism and schizophrenia [0.03%]
母体免疫激活小鼠模型中聚(I:C)诱导的肠道微生物群紊乱及自闭症和精神分裂症相关神经行为表型的纵向研究
Diego A González-Franco,Karina Corona-Cervantes,Paola C Bello-Medina et al.
Diego A González-Franco et al.
Maternal immune activation (MIA) induced by polyinosinic/cytidylic acid [poly(I:C)] is a widely used approach to study how gestational inflammation affects neurodevelopment. For this reason, we aimed to describe the changes in gut microbiot...
Peripheral nerve injury-induced upregulation of acyl-CoA synthetase 2 contributes to neuropathic pain via mediating microglial autophagy disruption in the spinal dorsal horn [0.03%]
外周神经损伤通过介导脊髓背角小胶质细胞自噬紊乱而上调酰基辅酶a合成酶2参与神经病理性疼痛发生发展中的作用研究
Yiming Qiao,Liren Li,Liying Bai et al.
Yiming Qiao et al.
Acyl-CoA synthetase 2 (ACSS2), by producing acetyl-coenzyme A from acetate in the nucleus, facilitates histone acetylation and regulates gene expression. However, the role of ACSS2 in neuropathic pain remains unclear. Herein, we found that ...