Exercise alleviates neuroinflammation and cognitive decline in aged mice via hepatic FGF21-driven microglial mitophagy [0.03%]
运动通过肝脏FGF21驱动的小胶质细胞线粒体自噬缓解老年小鼠神经炎症和认知衰退
Pengda Li,Tao Wu,Mengjie Chen et al.
Pengda Li et al.
Aging-associated neuroinflammation is a major contributor to cognitive decline, and exercise is an effective non-pharmacological intervention against it. However, the molecular mechanisms linking peripheral adaptations to exercise with cent...
Nikolaas Steele,Grant S Mannino,Tabitha R F Green et al.
Nikolaas Steele et al.
Sleep fragmentation disrupts physiological homeostasis, including thermoregulation, metabolism, and immune signaling; however, cellular mechanisms that stabilize core body temperature and sleep architecture during disrupted sleep remain poo...
IL-1β/IL-1R1 signaling mediates sleep deprivation-induced memory consolidation impairment and is a target for cognitive enhancement in male mice [0.03%]
IL-1β/IL-1R1信号介导的睡眠剥夺引起的记忆巩固损伤及其作为小鼠认知增强靶点的作用
Xinghe Wang,Mengqiu Deng,Dan Yu et al.
Xinghe Wang et al.
Sleep plays a critical role in memory consolidation; however, the precise molecular mechanisms linking sleep loss to cognitive impairment remain unclear. In this study, we show that even brief (4-h) sleep deprivation, when applied during th...
Primed to feel, not to flare: Early life adversity and psychological sensitivity to interleukin-6 in a randomized trial among middle-aged female breast cancer survivors [0.03%]
生命早期遭遇不幸与中年乳腺癌女性患者的身体敏感性：随机试验中的白细胞介素-6心理敏感性
Lauren Y Kim,Megan E Renna,M Rosie Shrout et al.
Lauren Y Kim et al.
Background: There have been recent calls to investigate potential moderators of inflammation's psychological effects in humans. In a small observational study, Kuhlman et al. (2020b) found that individuals with higher ear...
Exercise-induced modulation of kynurenine pathway metabolite patterns in multiple sclerosis: a targeted metabolomics analysis across four randomized controlled trials [0.03%]
多发性硬化症四项随机对照试验的运动诱导代谢组分析：对犬尿氨酸代谢模式的影响
Marie Kupjetz,Martin Langeskov-Christensen,Morten Riemenschneider et al.
Marie Kupjetz et al.
Kynurenine pathway imbalance is a characteristic feature of multiple sclerosis (MS). Serum kynurenines contribute to latent factors reflecting a neurotoxic (NeuroTox) or neuroprotective pattern (NeuroPro). Previous single-metabolite studies...
Long-term antibiotics treatment-induced anxiety-like behavior is associated with disrupted colonic tryptophan metabolism [0.03%]
长期抗生素治疗引起的类似焦虑行为与结肠色氨酸代谢紊乱有关
Jian Wu,Ting Li,Ao Wang et al.
Jian Wu et al.
The widespread and often excessive use of antibiotics has raised concerns about its long-term impact on host health. Growing evidence suggests that antibiotics-induced gut microbiota dysbiosis may contribute to neuropsychiatric conditions, ...
Modulating effects of creatine prevent sex-dependent hippocampal neuroinflammation, neuronal damage, and electrophysiological dysfunction induced by chronic colitis [0.03%]
肌酸的调节作用可防止慢性结肠炎诱导的海马神经炎症、神经元损伤和电生理功能障碍的性别差异出现
Alejandro Ruiz-Calero,María Ortego-Domínguez,María D Vázquez-Carretero et al.
Alejandro Ruiz-Calero et al.
Chronic inflammation in inflammatory bowel disease (IBD) disrupts the gut-brain axis, thereby inducing abnormal immune responses in the brain that are increasingly recognized as a source of neurological comorbidities. In the present work, w...
Inflammatory Proteins are Highly Variable During a Natural Stressor: A Call for Intensive Longitudinal Blood Microsampling [0.03%]
炎症蛋白在自然压力下的高度变化性：密集纵向血液微量采样呼吁
Daniel P Moriarity,Andrea C M Miller,Durga D Thota et al.
Daniel P Moriarity et al.
Although research into how inflammation mediates the effects of stress on disorders such as heart disease and depression has grown rapidly, standard longitudinal designs often have measurement lags of months or years between assessments. Th...
Omega-3 fatty acids, specialized pro-resolving mediators, and depression: A mechanistic meta-analysis of precursors and clinical implications [0.03%]
ω-3脂肪酸、促解析介质与抑郁：前体及临床意义的机制型meta分析研究
Ayesha Zafar Iqbal,Aimal Khan,Ikbal Andrian Malau et al.
Ayesha Zafar Iqbal et al.
Background: Omega-3 polyunsaturated fatty acids (n-3 PUFAs), especially eicosapentaenoic acid (EPA), exhibit adjunctive antidepressant efficacy despite negligible detectable levels in the brain. Emerging evidence implicat...
Breaking the cycle of loneliness: A randomized controlled trial of the anti-inflammatory naproxen in lonely, middle-aged adults [0.03%]
打破孤独的恶性循环——一项针对中年孤独者的抗炎药萘普生随机对照试验
Flora Blandl,Laura I Hazlett,Steven W Cole et al.
Flora Blandl et al.
Background: Loneliness poses a major public health concern linked to many adverse health outcomes. One proposed pathway linking loneliness to poor health is inflammation, and there is growing evidence of a bidirectional r...