Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats [0.03%]
阿片类药物诱发的老年大鼠术后认知功能障碍与海马线粒体功能异常有关
Stephanie M Muscat,Nicholas P Deems,Bryan D Alvarez et al.
Stephanie M Muscat et al.
Postoperative cognitive dysfunction (POCD) is a common and persistent complication in aging individuals following surgery, particularly when opioids are used for perioperative pain management. Although opioids are widely administered in the...
Blockade of semaphorin 3E attenuates neuroinflammation and mechanical hypersensitivity: implications for neuropathic pain therapy [0.03%]
塞法明3E信号通路在神经病理性疼痛中的作用及机制研究
Sato Yoshidomi,Takayuki Fujii,Hiroyuki Honda et al.
Sato Yoshidomi et al.
Background and objectives: Macrophage-associated responses at sites of nerve injury are involved in the initiation and persistence of neuropathic pain (NP). Immune semaphorins (SEMAs), including SEMA3A, SEMA3E, SEMA4A, SE...
Maternal gut microbiota disruption alters postpartum maternal behavior in association with modulation of stress responses and brain tryptophan metabolism in mice [0.03%]
母系肠道微生物群紊乱通过调节应激反应和大脑色氨酸代谢关联产后行为改变
Shiro Tochitani,Yasuko Yamamoto,Kuniaki Saito et al.
Shiro Tochitani et al.
The maternal gut microbiota serves as a primary source of microbial transmission to offspring and plays a critical role in offspring development; however, its contribution to maternal mental states during the perinatal period remains poorly...
Chronic stress promotes hepatic immune remodeling through glucocorticoid-driven neutrophil extracellular trap formation in gastric cancer liver metastasis [0.03%]
慢性应激通过糖皮质激素驱动的中性粒细胞胞外陷阱形成促进胃癌肝转移中的肝脏免疫重塑
Daoyue Wang,Weiwei Li,Lei Guan et al.
Daoyue Wang et al.
Chronic psychological stress is increasingly recognized as an important host-related determinant of cancer progression, yet how stress-associated neuroendocrine signaling reshapes the metastatic immune microenvironment remains incompletely ...
Peripheral toll-like receptor expression indicates distinct innate immune signatures in schizophrenia spectrum and mood disorders: A systematic review and meta-analysis [0.03%]
外周 Toll 样受体表达表明精神分裂症谱系和情绪障碍具有不同的先天免疫特征：系统评价和荟萃分析
Julia Karska,Szymon Kowalski,Kamila Rudy et al.
Julia Karska et al.
Background: Toll-like receptors (TLRs) are key pattern-recognition receptors initiating inflammatory signaling, and their peripheral mRNA levels may reflect disorder-specific innate immune activation. Dysregulation of inn...
Neuroimmune crosstalk in HIV-associated neurocognitive disorders and the impact of antiretroviral therapy [0.03%]
人类免疫缺陷病毒相关神经认知障碍的神经免疫相互作用及抗逆转录病毒治疗的影响
George Chigozie Njoku,Elizabeth Etafo,Ukamaka Obiamaka Modebelu et al.
George Chigozie Njoku et al.
HIV-associated neurocognitive disorders (HAND) remain prevalent among people living with HIV (PLWH) despite effective combination antiretroviral therapy (cART) and durable systemic viral suppression. The central nervous system (CNS) represe...
Psychoneuroimmunology-informed strategies for early detection of biological threat exposure: Insights from experimental rodent models [0.03%]
受心理神经免疫学启发的早期检测生物威胁暴露策略：实验啮齿动物模型的启示
Michail Laoumtzis,Samuel G Evans,Daniel Barratt et al.
Michail Laoumtzis et al.
The growing frequency of emerging infectious diseases, antimicrobial resistance, and accidental or deliberate biological threat releases underscores the urgent need for early detection of biological threat exposure. Current diagnostic appro...
EPA restores neuroimmune homeostasis in Schizophrenia: evidence for the involvement of autophagy [0.03%]
表观遗传学改变恢复了自闭症患者的神经免疫稳态：自噬参与的证据
Ling Yan,Xiaona Wang,Yongping Zhang et al.
Ling Yan et al.
Immune dysregulation, particularly inflammation, may contribute significantly to the pathophysiology of schizophrenia (SZ). Autophagy is an essential cellular process that maintains neuroimmune homeostasis, but its relationship with inflamm...
Monray E Williams
Monray E Williams