A Delphi-method-based consensus for clinical domains and assessment of the inflammatory subtype of major depressive disorder from the ASPIRE study [0.03%]
ASPIRE研究中的炎症亚型抑郁症临床领域及评估的共识（基于Delphi方法）
Benedetta Vai,Tommaso Cazzella,Camilla Monopoli et al.
Benedetta Vai et al.
Background: Elevated inflammatory biomarkers have been consistently associated with a subset of depressive symptoms, particularly atypical and energy-related features, as well as antidepressant treatment resistance. This ...
New-onset autoimmunity in people living with post-traumatic stress disorder [0.03%]
患有创伤后应激障碍人群中的自身免疫新发疾病
Yovel Cohen,Meir Schechter,Dvora R Sehtman-Shachar et al.
Yovel Cohen et al.
Background: Prior observational studies suggested an association between post-traumatic stress disorder (PTSD) and autoimmune disorders; however, a comprehensive evaluation of this relationship remains limited. ...
Intermittent fasting alleviates neuropathic pain and cognitive deficits via an Alistipes finegoldii-Hippuric Acid-STING neuroimmune axis [0.03%]
间歇性禁食通过Alistipes finegoldii-hippuric acid-STING神经免疫轴缓解神经病理性疼痛和认知缺陷
Xin Ding,Di Qiu,Xin-Yu Li et al.
Xin Ding et al.
Chronic pain is frequently accompanied by cognitive and affective impairments, yet effective non-pharmacological interventions remain limited. Here, we show that intermittent fasting (IF) alleviates mechanical allodynia, thermal hyperalgesi...
Differential consequences of traumatic brain injury in male rat hippocampus hemispheres and the beneficial effect of neuropeptide Y [0.03%]
神经肽Y对雄性大鼠海马半球的创伤性脑损伤的不同影响及改善作用
Ricardo A Leitão,José L Alves,Ana L Bernardo et al.
Ricardo A Leitão et al.
Traumatic brain injury (TBI) initiates a complex cascade of secondary injury mechanisms, including neurovascular dysfunction, neuroinflammation, and glial activation, which progressively contribute to long-term neurological deficits. Althou...
Prenatal exposure to environmental stressors alters gut macrophage development and gastrointestinal function of male offspring [0.03%]
孕期环境刺激暴露会改变后代男性肠道巨噬细胞发育和胃肠功能
Dang M Nguyen,Sarah K Monroe,A Brayan Campos-Salazar et al.
Dang M Nguyen et al.
Gastrointestinal (GI) dysfunction is a frequently reported comorbidity of neurodevelopmental disorders (NDDs). Early-life inflammatory challenges from the environment (e.g., infection, toxicants) can increase risk for NDDs, but the impact o...
SIK2-P300 axis Orchestrates the metabolic reprogramming and Immunological functions in microglia of Alzheimer's disease mice via a dual modulation of lactylation and Acetylation: An epigenetic Perspective [0.03%]
基于乳酰化和乙酰化的双重调控：从表观遗传学角度探究SIK2-P300轴在阿尔茨海默病小胶质细胞代谢重塑及免疫功能中的作用机制
Xiaoman Dai,Ziling Ye,Xujun Zhang et al.
Xiaoman Dai et al.
Metabolic dysfunction in microglia is increasingly recognized as a core driver of Alzheimer's disease (AD) pathogenesis, and yet the underlying mechanisms remain elusive. Here, we identified salt-inducible kinase 2 (SIK2) as a critical meta...
Deletion of RGS5 attenuates high-fat diet-induced cerebrovascular pathology and associated spatial memory deficits [0.03%]
RGS5基因缺失可减轻高脂饮食诱导的脑血管病理改变及相关的空间记忆缺损
Osama F Elabi,Shubhangini Tiwari,Alba M Garcia-Serrano et al.
Osama F Elabi et al.
Diet-induced metabolic dysregulation is associated with cerebral microvascular pathology contributing to cognitive decline and vascular dementia. These alterations include blood-brain barrier (BBB) leakage, pericyte dysfunction, aberrant an...
KATP channel functional remodeling is associated with neuroinflammatory and dopaminergic alterations under metabolic stress in female mice [0.03%]
代谢压力下雌性小鼠Kir6.2钾通道功能重塑与神经炎症和多巴胺能改变有关
Chung-Lin Chen,Pei-Yu Li,Hao-Yeh Tsai et al.
Chung-Lin Chen et al.
Metabolic stress and neuroinflammation are associated with depression, but the mechanisms connecting peripheral metabolic dysfunction to reward-related circuit alterations remain incompletely understood. ATP-sensitive potassium (KATP) chann...
Additive effects of anxiety/depression and transportation noise exposure on cardiovascular risk and measures of neural-immune mechanisms [0.03%]
焦虑/抑郁与交通噪声暴露对心血管风险及神经免疫机制指标的累加效应研究
Fatima Saeed,Krystel AbiKaram,Shady Abohashem et al.
Fatima Saeed et al.
Background: Transportation noise exposure and stress-related psychiatric conditions (e.g., anxiety, depression) are well-known contributors to cardiovascular disease (CVD). Both exposures activate shared biological pathwa...
Systematic review on associations of cancer-related fatigue with proinflammatory cytokines: IL-1alpha, IL-1beta, IL-6, TNF-alpha [0.03%]
癌症相关性疲劳与炎症因子：IL-1α、IL-1β、IL-6和TNF-α的相关性系统评价
Hee-Ju Kim,Soyoun Park,Mi-Kyung Yuk et al.
Hee-Ju Kim et al.
Objectives: This systematic review aimed to identify patterns of associations between cancer-related-fatigue and IL-1α, IL-1β, IL-6, and TNF-α in the literature to examine the influence of major clinical factors (e.g.,...