Transcriptomic and proteomic profiling of bi-partite and tri-partite murine iPSC-derived neurospheroids under steady-state and inflammatory condition [0.03%]
小鼠多能干细胞来源的双组分和三组分神经球在稳态和炎症条件下的转录组和蛋白质组分析
Julia Di Stefano,Laura Garcia-Pupo,Federica Di Marco et al.
Julia Di Stefano et al.
induced-pluripotent stem cell (iPSC)-derived neurospheroid (NSPH) models are an emerging in vitro toolkit to study the influence of inflammatory triggers on neurodegeneration and repair in a 3D neural environment. In contrast to their human...
A rapidly progressive multiple system atrophy-cerebellar variant model presenting marked glial reactions with inflammation and spreading of α-synuclein oligomers and phosphorylated α-synuclein aggregates [0.03%]
一种快速进展的多系统萎缩小脑变异型模型，表现出明显的胶质反应、炎症以及α-突触核蛋白寡聚体和磷酸化α-突触核蛋白聚集物的扩散现象
Hiroo Yamaguchi,Yuji Nishimura,Dai Matsuse et al.
Hiroo Yamaguchi et al.
Multiple system atrophy (MSA) is a severe α-synucleinopathy facilitated by glial reactions; the cerebellar variant (MSA-C) preferentially involves olivopontocerebellar fibres with conspicuous demyelination. A lack of aggressive models that...
Spinal cord injury disrupts plasma extracellular vesicles cargoes leading to neuroinflammation in the brain and neurological dysfunction in aged male mice [0.03%]
脊髓损伤通过破坏血浆外泌体导致老年雄性小鼠大脑神经炎症及神经功能障碍
Zhuofan Lei,Balaji Krishnamachary,Niaz Z Khan et al.
Zhuofan Lei et al.
Aged individuals with spinal cord injury (SCI) are prevalent with increased mortality and worse outcomes. SCI can cause secondary brain neuroinflammation and neurodegeneration. However, the mechanisms contributing to SCI-induced brain dysfu...
Microglia undergo molecular and functional adaptations to dark and light phases in male laboratory mice [0.03%]
小鼠的小胶质细胞在昼夜节律中会发生分子和功能的适应性变化
Daniele Mattei,Andranik Ivanov,Jacqueline Hammer et al.
Daniele Mattei et al.
Microglia are increasingly recognized to contribute to brain health and disease. Preclinical studies using laboratory rodents are essential to advance our understanding of the physiological and pathophysiological roles of these cells in the...
Hunting the origin and source of NR1-directed IgGs in patients with encephalitis [0.03%]
寻找脑炎患者中NR1导向IgG的起源和源头
Jonathan Cleaver,Russell Dale,Sarosh R Irani
Jonathan Cleaver
Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression [0.03%]
泛蛋白质组分析鉴定出调控淀粉样蛋白-β进展的血浆免疫调节因子
Michael R Duggan,Gabriela T Gomez,Cassandra M Joynes et al.
Michael R Duggan et al.
While immune function is known to play a mechanistic role in Alzheimer's disease (AD), whether immune proteins in peripheral circulation influence the rate of amyloid-β (Aβ) progression - a central feature of AD - remains unknown. In the ...
Modulation of microglia activation by the ascorbic acid transporter SVCT2 [0.03%]
抗坏血酸转运蛋白SVCT2调节小胶质细胞活化
Amanda L Marino,Tonia S Rex,Fiona E Harrison
Amanda L Marino
Neuroinflammation is a major characteristic of pathology in several neurodegenerative diseases. Microglia, the brain's resident myeloid cells, shift between activation states under neuroinflammatory conditions, both responding to, but also ...
Bacterial peptidoglycan signalling in microglia: Activation by MDP via the NF-κB/MAPK pathway [0.03%]
细菌肽聚糖的信号传导：MDP通过NF-κB / MAPK途径活化微胶质细胞
Julia Spielbauer,Elliot J Glotfelty,Heela Sarlus et al.
Julia Spielbauer et al.
Bacterial peptidoglycan (PGN) fragments are commonly studied in the context of bacterial infections. However, PGN fragments recently gained recognition as signalling molecules from the commensal gut microbiota in the healthy host. Here we f...
Remote dried blood spot collection for inflammatory markers in older adults is feasible, reliable, and valid [0.03%]
远程采集老年人炎症标志物干血斑样本是可行的、可靠的和有效的
Rebecca G Reed,Abby R Hillmann,Maegan Nation et al.
Rebecca G Reed et al.
Dried blood spots (DBS) provide a minimally invasive method to assess inflammatory markers and can be collected remotely at-home or in-person in the lab. However, there is a lack of methodological information comparing these different colle...