Exercise-induced FNDC5/irisin promote stress resilence in mice by targeting astrocytic GLT1 in the amygdala [0.03%]
运动诱导的FNDC5/irisin通过靶向杏仁体星形胶质细胞GLT1促进小鼠压力复原力
Yang Liu,Yanbo Zhao,Yingying Zhang et al.
Yang Liu et al.
Physical exercise (PE) benefits both physical fitness and cognitive function. As a major source of myokines, skeletal muscle links PE to brain health. Irisin, cleaved from FNDC5, is a PE-induced myokine that crosses the blood-brain barrier ...
Association of CBC-derived indices of inflammation with mortality in patients with PTSD [0.03%]
基于CBC衍生的炎症指标与PTSD患者的死亡率之间的关联性研究
Luke Rozema,Bradley V Watts,Sarah Cornelius et al.
Luke Rozema et al.
Objective: Posttraumatic stress disorder (PTSD) has been associated with immune activation and inflammation. Current methods of measuring inflammation in electronic health records (EHR) data are limited. The present study...
Pramipexole promotes CD8+ regulatory T cell-dependent neuroprotection in Parkinson's disease patients [0.03%]
普拉米派克斯促进帕金森病患者CD8⁺调节性T细胞依赖的神经保护作用
Gallegos-Altamirano Edwin,Castillo-Arellano Jorge,Pérez Figueroa Erandi et al.
Gallegos-Altamirano Edwin et al.
Background: Parkinson's disease (PD) is caused by the death of dopaminergic neurons. Since immune system cells express dopamine receptors, dopaminergic agonists may modify their function. However, the effects of dopaminer...
Antiviral and anti-inflammatory effects of Cannabidiol in HIV/SIV infection [0.03%]
大麻二酚对HIV/SIV感染的抗病毒和抗炎作用
Alysha L Ellison,José Javier Rosado-Franco,Labib Mamun et al.
Alysha L Ellison et al.
Persistent reservoirs and chronic immune activation are hallmarks of HIV, despite the effectiveness of antiretroviral therapy (ART) in suppressing viral replication. Here, we use rhesus macaques and primary and induced pluripotent stem cell...
Peripheral inflammation is associated with emotional dysregulation, suicide attempts, and reduced microstructural integrity of white matter in young adults with borderline personality disorder [0.03%]
边缘炎症与情绪失调、自杀企图以及年轻成人边缘型人格障碍患者的白质微结构完整性降低有关
Giulia Quattrini,Nadia Cattane,Chiara Galbiati et al.
Giulia Quattrini et al.
Background: Borderline personality disorder (BPD) is a psychiatric condition characterized by functional impairment and high rates of suicide attempts. Although its pathophysiology is still unclear, emerging evidence sugg...
OTUD1 promotes the progession of depression through mitochondrial damage by targeting MST1/2 [0.03%]
OTUD1通过靶向MST1/2促进抑郁症发展的线粒体损伤作用
Chengde Wang,Dongping Huang,Jian Wang et al.
Chengde Wang et al.
Mitochondrial dysfunction is a key feature of depressive disorders. This study investigated whether ovarian tumor domain-containing ubiquitin aldehyde-binding protein 1 (OTUD1) regulates mitochondrial abnormalities contributing to depressio...
Mammary tumors-derived exosomes induce striatal NF-κB signaling, microglial reactivity, and anxiety/depression-like behaviors [0.03%]
乳腺肿瘤来源的外泌体诱导纹状体内NF-κB信号、小胶质细胞活化及类似焦虑/抑郁的行为反应
Yuan-Yuan Han,Ji-Chao Wu,Hong-Mei Yang et al.
Yuan-Yuan Han et al.
Emerging evidence links peripheral cancer growth with affective disturbances, yet the mechanisms bridging tumor biology and central dysfunction remain poorly defined. In a cohort of newly diagnosed breast cancer patients and healthy control...
Systemic oxidative stress in children and adolescents with attention deficit hyperactivity disorder: a meta-analysis of oxidative and antioxidant biomarkers [0.03%]
注意缺陷多动障碍儿童和青少年全身氧化应激水平的meta分析研究
Patricia Marest Suwindi,Ikbal Andrian Malau,Kuan-Pin Su et al.
Patricia Marest Suwindi et al.
Objective: Emerging evidence has shown that an exacerbation of oxidative stress and a reduction of antioxidant activity may be implicated in the pathophysiology of attention deficit hyperactivity disorder (ADHD). Neverthe...
Authentic artworks or real environments? Implications of real-world experiences for the neuroimmune system [0.03%]
真正的艺术品还是真实环境？现实体验对神经系统免疫系统的意义
Laura Nataly Panqueva Giraldo,John Leonardo Torres Castiblanco,David Fernando Torres Cortes
Laura Nataly Panqueva Giraldo
S100A8/A9 blockade attenuates autoimmune neuroinflammation by regulating the heterogeneity and function of neutrophils [0.03%]
S100A8 / A9 阻断通过调节中性粒细胞的异质性和功能来减轻自身免疫神经炎症
Weizhao Li,Xiang Fang,Xinyu Zhang et al.
Weizhao Li et al.
Patients with multiple sclerosis (MS) exhibit elevated levels of calprotectin S100A8/A9 in the blood, bone marrow (BM), and feces. However, the potential of targeting S100A8/A9 as a therapeutic approach for MS treatment remains to be fully ...