Nanotechnology-assisted thermal ablation for hepatocellular carcinoma: Focus on radiofrequency and microwave ablation [0.03%]
纳米技术辅助热消融治疗肝细胞癌的进展：重点关注射频和微波消融技术
Changzheng Li,Jianji Ke,Xiaocheng Li et al.
Changzheng Li et al.
Background: Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality. Radiofrequency ablation (RFA) and microwave ablation (MWA) are established local therapies for early-stage and selected interme...
A prognostic immune signaling-related lncRNA-circRNA-mRNA network model for cervical cancer using machine learning [0.03%]
基于机器学习的宫颈癌免疫信号相关lncRNA-circRNA-mRNA网络模型的预后研究
V B Navya,Geethu Muraleedharan,P K Fasna et al.
V B Navya et al.
Cervical cancer, the third most common cancer worldwide with 50% increase in mortality, is a growing public health concern. Recent research on non-coding RNAs including long coding RNAs (lncRNAs) and circular RNAs (circRNAs) highlights thei...
Luteolin reduces glucose uptake and malignant phenotypes in pancreatic ductal adenocarcinoma cells: an integrated bioinformatics and in vitro study [0.03%]
黄酮类化合物山柰酚通过生物信息学和体外实验研究降低葡萄糖摄入和恶性表型在胰腺导管腺癌细胞中的作用
Yunyao Wei,Xiaolan Huang,Ying Mei et al.
Yunyao Wei et al.
Pancreatic ductal adenocarcinoma (PDAC) exhibits marked metabolic plasticity, but the effects of luteolin on glucose utilisation in PDAC cells remain unclear. We integrated predicted luteolin targets with bulk and single-cell transcriptomic...
hsa-miR-9-FABP7 axis as a predictive biomarker for metastatic progression in triple-negative breast cancer: An integrated analysis [0.03%]
整合分析揭示hsa-miR-9-FABP7轴可作为三阴性乳腺癌转移进展的预测生物标志物
Deepshikha Rathore,Vasundhara Dheer,Surbhi Singh et al.
Deepshikha Rathore et al.
Metastasis remains the primary cause of breast cancer mortality. Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype. It lacks targeted therapies and carries a high risk of metastasis. MiRNAs are one of the pot...
Repeated intravenous mesoporous silica nanoparticle exposure increases serum total bile acids and alters hepatic bile acid-related gene expression in mice [0.03%]
反复静脉注射介孔二氧化硅纳米粒子可增加小鼠血清总胆汁酸并改变肝中相关基因的表达
Jing Li,Hui Xu
Jing Li
Mesoporous silica nanoparticles (MSNs) are promising drug-delivery materials, but their effects on hepatobiliary metabolic endpoints remain incompletely characterized. This study examined whether repeated systemic MSN exposure affects serum...
The bone metastatic niche enhances GJA1-20k expression and mitochondrial remodeling in metastatic prostate cancer cells [0.03%]
骨转移生态位增强转移性前列腺癌细胞中GJA1-20k表达和线粒体重塑
Sarah Fournier,Nicolas Delannoye,Isabelle Courtin et al.
Sarah Fournier et al.
Bone metastases are a major cause of morbidity in advanced prostate cancer (PCa), where tumor cells adapt to a hypoxic and osteoblast-rich microenvironment. Here, we investigated how endosteal niche conditions regulate GJA1-20k expression a...
IFITM3 promotes triple-negative breast cancer progression by regulating β-catenin localization [0.03%]
IFITM3通过调节β-连环素定位促进三阴性乳腺癌进展
Heeyeon Kim,Youngim Yu,Yuseon Park et al.
Heeyeon Kim et al.
Interferon-induced transmembrane protein 3 (IFITM3) is best known as an antiviral protein, but accumulating evidence supports pro-tumorigenic functions across several cancers. Here, we examined IFITM3 in triple-negative breast cancer (TNBC)...
SYTL4 acts as a tumor suppressor in colorectal cancer by promoting ubiquitination and degradation of SEC31B [0.03%]
SYTL4通过促进SEC31B泛素化和降解在结直肠癌中发挥抑癌作用
Jinlei Li,Xiaodong Zhang,Hongyan Li et al.
Jinlei Li et al.
Colorectal cancer (CRC) pathogenesis involves complex alterations in tumor suppressor genes and oncogenes. Although ubiquitin-mediated proteolysis represents a well-established regulatory mechanism, the functions of many E3 ubiquitin ligase...
The role of the LPC/ATX/LPA axis in metabolic dysfunction-associated steatotic liver disease [0.03%]
LPC/ATX/LPA轴在代谢功能异常相关肝脂肪变性疾病中的作用
Yuwei Liu,Lu Qiao
Yuwei Liu
Autotaxin (ATX) possesses lysophospholipase D (lysoPLD) activity and catalyzes the conversion of lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). The LPC/ATX/LPA axis plays a pivotal role in lipid metabolism and lipid-mediate...