Integrated transcriptomic and functional analyses identify PRR7 as a therapeutic target that associated with Wnt/β-catenin signaling and docetaxel resistance in prostate cancer [0.03%]
整合转录组和功能分析确定PRR7是与Wnt/β-catenin信号传导和多西他赛耐药相关的前列腺癌治疗靶点
Wei Sun,Yuheng Si,Lu Hong et al.
Wei Sun et al.
Background: Docetaxel resistance represents a major therapeutic challenge in advanced prostate cancer. Despite extensive studies on drug efflux, apoptosis, and metabolic adaptation, the specific cellular states and molecu...
Pharmacological blockade of oncogenic MAPK activators drives resistance to cystine deprivation with lipid redox remodeling [0.03%]
药理学阻断致癌MAPK活化剂通过脂质氧化还原重塑驱动半胱氨酸剥夺耐药性
Tomomiki Noda,Hitomi Shirahama,Yuri Tani et al.
Tomomiki Noda et al.
Targeted therapies disrupt oncogenic signaling while inducing adaptive metabolic rewiring for cancer cell survival. However, the roles of acute metabolic shifts remain poorly understood. Here, we showed that inhibiting EGFR, KRAS, or BRAF d...
Cross-species causal gene mapping reveals brain-region-specific targets of Cannabidiol for post-traumatic stress disorder treatment [0.03%]
跨物种因果基因定位揭示大麻二酚治疗创伤后应激障碍的脑区特异性靶点
Hui Rao,Guanbo Xie,Ning Wu et al.
Hui Rao et al.
Purpose: Post-traumatic stress disorder (PTSD) involves hippocampal and prefrontal dysfunction. Cannabidiol (CBD) shows therapeutic promise, but its cell-type-specific and causal mechanisms remain unclear. ...
gp91phox regulates Hv1 channel gating and membrane trafficking via direct interaction [0.03%]
GP91PHOX通过直接相互作用调节Hv1通道门控和膜转运
Shivani Yadav,Ashutosh Sharma,Kunvar Ravendra Singh et al.
Shivani Yadav et al.
Voltage-gated proton channel (Hv1) and the NADPH oxidase (NOX2) functionally cooperate to support ROS generation in immune cells through electrochemical coupling. However, whether NOX2 components directly regulate Hv1 channel behavior remai...
Helicobacter pylori small RNA HPnc1470 represses HP0499/PldA/CGAT expression and modulates gastric epithelial morphology and inflammation [0.03%]
幽门螺杆菌小分子RNA HPnc1470通过抑制HP0499/PldA/CGAT表达调控胃黏膜上皮形态和炎症反应
Kana Nishida,Eisuke Kuroda,Kouji Kimura et al.
Kana Nishida et al.
Helicobacter pylori persistently colonizes the stomach and contributes to gastric inflammation and carcinogenesis via sustained interactions with gastric epithelial cells. Although bacterial small RNAs (sRNAs) are crucial post-transcription...
Ryo Muko,Kenshiro Matsuda,Masa-Aki Oikawa et al.
Ryo Muko et al.
Atopic dermatitis (AD) is one of the intractable chronic inflammatory diseases and is often accompanied by mental disorders, such as depression. On the other hand, depression has been pointed out to be strongly associated with the onset of ...
Retraction notice to "Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome" [Biochem. Biophys. Res. Commun. 493 (2017) 821-826] [0.03%]
有关“姜黄素通过AMPK-NRF2信号通路减轻帕金森病”[生化与生物物理学报493（2017）821-826]的撤稿通知
Shimeng Zhang,Liangjun Jiang,Fengyuan Che et al.
Shimeng Zhang et al.
Pathogenesis and role of ferroptosis mediated by Nrf2 signaling pathway in ischemic stroke [0.03%]
缺血性卒中发生发展的Nrf2信号通路依赖的铁死亡机制及作用研究
Nitong Ying,Yongyan Wang,Zirong Li et al.
Nitong Ying et al.
Ferroptosis, a novel mode of programmed cell death, plays a significant role in neurological injury following ischemic stroke (IS). Nuclear factor E2-related factor 2 (Nrf2), a central transcription factor that combats oxidative stress, is ...
System xc- deficiency suppresses microglial glutamate release and inflammation, ameliorating motor dysfunction and anxiety-like behaviors in aged mice [0.03%]
系统xc缺乏抑制小胶质细胞谷氨酸释放和炎症，缓解老年小鼠运动障碍和类似焦虑的行为
Yugo Kato,Tsumugi Takemoto,Masaki Yabe et al.
Yugo Kato et al.
Elevated extracellular glutamate and neuroinflammation are well-established contributors to aging-related phenotypes. However, the cellular sources of extracellular glutamate and the underlying molecular mechanisms remain poorly understood....
Mechanical crowding induces HDAC6 nuclear export with functional involvement of XPO1 in HeLa cells [0.03%]
机械拥挤使HDAC6从核中运出并参与HeLa细胞中XPO1的功能作用
Shukai Li,Jing Du
Shukai Li
During tumor progression, cells within the solid tumor core experience substantial mechanical crowding (solid stress). Although HDAC6 is a key regulator of cell survival and motility, its spatial regulation under physical crowding remains p...