FGF21 attenuates sepsis-induced myocardial injury via AMPK-mediated mitochondrial biogenesis [0.03%]
FGF21通过AMPK介导的线粒体生物发生缓解脓毒症诱导的心肌损伤
Liping Mao,Dan Dang,Wenjing Wang
Liping Mao
Sepsis is a life-threatening infection that often leads to myocardial injury. Here we explored the role of fibroblast growth factor 21 (FGF21) in sepsis-induced myocardial injury and its underlying mechanism. A mouse model of sepsis-associa...
Dietary fatty acids modulate lipolytic enzymes via distinct allosteric and exosite mechanisms: An integrated in vivo and in silico study linking Cafeteria diet-induced obesity to altered lipid metabolism [0.03%]
饮食脂肪酸通过不同的别构和exo-site机制调节脂解酶：整合体内和计算研究将自助餐厅饮食引起的肥胖与改变的脂质代谢联系起来
Meryem Bensalah,Samira Bouanane,Fatima Zohra Baba Ahmed
Meryem Bensalah
The escalating prevalence of obesity necessitates a deeper molecular understanding of how high-fat diets disrupt lipid metabolism. This study aimed to elucidate the potential mechanisms by which dietary fatty acids (FAs) modulate the key li...
PLM-ArgMe: Protein language model for arginine methylation prediction for different species [0.03%]
基于蛋白质语言模型的跨物种精氨酸甲基化位点预测（PLM-ArgMe）
Nitika Bhatt,Kartik Joshi,Ranjeet Kumar Rout et al.
Nitika Bhatt et al.
Protein methylation is a crucial post-translational modification (PTM) responsible for many diseases and accurate prediction of the methylation site is important for understanding the molecular mechanism of the disease. The models have been...
Nucleolar integrity in isolated nucleoli is governed by electrostatic interactions and altered by disease-associated proteins [0.03%]
疾病相关蛋白改变核酸体的完整性和内稳态：核酸体内静电相互作用决定索罗小体的完整性及内稳态
Hiroaki Suzuki,Mai Takahashi,Tamami Miyagi et al.
Hiroaki Suzuki et al.
The nucleolus is a biomolecular condensate maintained by multivalent intermolecular interactions. However, the physicochemical interactions that preserve the nucleolar integrity remain poorly understood. We established an isolated nucleolus...
Nucleolar integrity in isolated nucleoli is governed by electrostatic interactions and altered by disease-associated proteins [0.03%]
疾病相关蛋白质改变核仁的完整性及带电离子的作用
Hiroaki Suzuki,Mai Takahashi,Tamami Miyagi et al.
Hiroaki Suzuki et al.
The nucleolus is a biomolecular condensate maintained by multivalent intermolecular interactions. However, the physicochemical interactions that preserve the nucleolar integrity remain poorly understood. We established an isolated nucleolus...
Chemical induction enhances patient-derived organoid fidelity to primary colorectal cancer at the single-cell level: A re-analysis of public scRNA-seq dataset GSE261012 [0.03%]
化学诱导增强患者衍生类器官与原发性结直肠癌在单细胞水平上的一致性：对公共scRNA-seq数据集GSE261012的重新分析
Feng Libo,Xia Dong,Liu Yu
Feng Libo
Background: Patient-derived organoids (PDOs) are widely used preclinical models for colorectal cancer (CRC). However, conventional PDO cultures frequently lose tumor microenvironment (TME) components and undergo culture-i...
Single-cell transcriptomics reveals CD8 + T-cell heterogeneity linked to immunotherapy response in gastric cancer [0.03%]
单细胞转录组揭示胃癌中与免疫治疗反应相关的CD8+T细胞异质性
Mingde Zang,Yi Xuan,Guanlin Li et al.
Mingde Zang et al.
Immune checkpoint blockade elicits durable responses in a subset of patients with gastric cancer, yet the cellular programs underlying therapeutic divergence remain unclear. Using integrative single-cell transcriptomics of tumors from Immun...
Rutin targeting NOX4 alleviates sepsis-induced acute lung injury via inhibition of NET formation through the ROS/MAPK/PAD4 pathway [0.03%]
rutin靶向NOX4通过ROS/MAPK/PAD4信号通路抑制NETs形成缓解脓毒症诱导的急性肺损伤
Yanhui Zhu,Mengdi Shao,Qi Zheng et al.
Yanhui Zhu et al.
Neutrophil extracellular traps (NETs) have been identified as pivotal contributors in driving excessive inflammation and organ damage during sepsis. Rutin has shown broad therapeutic potentials in inflammatory, infection, and cancer disease...
Novel chitosan/hydroxypropyl methylcellulose/propylene glycol hydrogel containing lyophilized amniotic membrane particles for wound healing: Synthesis and optimization [0.03%]
一种新的含有冻干胎盘膜颗粒的壳聚糖/2-羟丙基甲基纤维素/丙二醇水凝胶的制备及其伤口愈合性能研究
Zahra Chegeninezhad,Mohsen Setayeshmehr,Mehrdad Zeinalian et al.
Zahra Chegeninezhad et al.
Chronic wounds pose challenges due to delayed healing and infection risks. Advanced dressings that provide moisture, support, and bioactivity are critical for regeneration. Hydrogels offer high water content and biocompatibility, while the ...
Hsa-miR-498-5p serves as a diagnostic biomarker and regulates endothelial dysfunction via PTEN/AKT pathway in gestational hypertension [0.03%]
miR-498-5p可作为妊娠高血压的诊断标志物并通过PTEN/AKT信号通路调节血管内皮细胞功能异常
Man Chen,Fang Zong,Jingjing Zhang et al.
Man Chen et al.
Background: Gestational hypertension (GH) remains a major cause of maternal and fetal morbidity. miR-498 has been implicated in vascular dysfunction, yet its role and mechanism in GH remain unclear. ...