Integrated network pharmacology and experimental models uncover the mechanism of procyanidin B2 against ovarian carcinoma via EGFR/AKT pathway [0.03%]
基于网络药理学和实验模型的棓儿茶素B2通过EGFR/AKT信号通路抑制卵巢癌的机制研究
Tianyu Zhou,Qihua Sun,Chen Su et al.
Tianyu Zhou et al.
Ovarian carcinoma (OC) remains a lethal malignancy with limited therapeutic options. Procyanidin B2, a natural flavonoid, has demonstrated broad bioactivity, yet its potential role in ovarian cancer remains incompletely understood. This stu...
Guggulsterone attenuates UVB-induced oxidative stress and inflammation in keratinocyte HaCaT cells via HO-1 induction [0.03%]
姜黄素生物活性成分诺福丁通过诱导HO-1降低UVB诱导的角质形成细胞氧化应激和炎症反应
Dong-Uk Kim,Bitna Kweon,Gyeong-Ran Noh et al.
Dong-Uk Kim et al.
Ultraviolet B (UVB) radiation is a potent environmental stressor known to induce oxidative damage and inflammatory responses in skin keratinocytes, contributing to photoaging and photocarcinogenesis. Guggulsterone (GS), a phytosterol derive...
Engineered MSCs secreting GLP-1 enhance β-cell survival and improve glycemic control in diabetic mice [0.03%]
分泌GLP-1的工程间充质干细胞可增强β细胞存活并改善糖尿病小鼠血糖控制能力
Zheng Huang,Yuyi Zhang,Jingwen Tian et al.
Zheng Huang et al.
Type 1 diabetes (T1D) arises from autoimmune destruction of pancreatic β-cells, leading to insufficient insulin production and impaired glucose regulation. Although insulin therapy and islet transplantation remain the primary treatment opt...
Green synthesis of chitosan-coated silver nanoparticles from Tephrosia apollinea plant: A promising sustainable approach to colorectal cancer treatment [0.03%]
基于唐松草植物的壳聚糖包被银纳米粒子的绿色合成：一种有前景的大肠癌治疗方法
Shifa Malik,Rania Hamdy,Khalid Bajou et al.
Shifa Malik et al.
The development of targeted, biocompatible nanomaterials is essential for improving colorectal cancer (CRC) therapy. This study aims to establish a sustainable nanoparticle platform using Tephrosia apollinea, a medicinal plant, for targeted...
Olaparib has synergistic effects with DNA damaging agents in pancreatic ductal adenocarcinoma [0.03%]
奥拉帕利联合DNA损伤剂在胰腺导管腺癌中的协同效应研究
Bahareh Hassani,Amirsajad Jafari,Marjan Tavakkoli et al.
Bahareh Hassani et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) remains among the most lethal malignancies. Poly (ADP-ribose) polymerase (PARP) enzymes have a crucial function in the DNA repair and their inhibition has been recently ...
Targeting DHODH promoter G-quadruplex to induce ferroptosis in melanoma cells [0.03%]
靶向DHODH启动子G-四链体以在黑色素瘤细胞中诱导铁死亡
Wenhe Zhang,Qi Xu,Yutong Sui
Wenhe Zhang
Dihydroorotate dehydrogenase (DHODH) is a key regulator of ferroptosis and represents a promising therapeutic target in cancer. However, the mechanisms underlying its aberrant overexpression in tumors, particularly the cis-regulatory elemen...
UDP-galactose limitation impairs efficient Monogalactosyldiacylglycerol production in Escherichia coli expression strains [0.03%]
UDP半乳糖限制会损害大肠杆菌表达菌株中单半乳糖二酰基甘油的高效产生
Łukasz Hałys,Michał Gabruk
Łukasz Hałys
Monogalactosyldiacylglycerol (MGDG) is the most abundant lipid in photosynthetic membranes, playing critical roles in its architecture and protein function. Studying these roles is challenging in native systems, making heterologous expressi...
The role and mechanism of asiaticoside in regulating smooth muscle cell mitochondrial Drp1 during neointimal hyperplasia and atherosclerosis [0.03%]
Asiaticoside在调节平滑肌细胞线粒体Drp1中的作用及机制在不内膜增生和动脉粥样硬化中的作用及机制研究
Mingyu Liu,Lu Wang,Lina Wang et al.
Mingyu Liu et al.
Early atherosclerosis is characterized by aberrant proliferation and migration of vascular smooth muscle cells (VSMCs). Asiaticoside (ASI), the primary bioactive constituent of Centella asiatica, has been demonstrated to possess anti-inflam...
Endoplasmic reticulum membrane complex 1 facilitates BK polyomavirus genotype III/IV replication for nephropathy [0.03%]
内质网膜复合物1通过促进BK多瘤病毒III/IV基因型复制而导致肾病
Shota Fukae,Shigeaki Nakazawa,Soichi Matsumura et al.
Shota Fukae et al.
BK polyomavirus nephropathy (BKPyVN) remains a major cause of renal allograft dysfunction. However, the influence of viral genotype on disease progression and host-virus interactions is not fully understood. We examined kidney transplant re...
Observations on IL-2-inducible tyrosine kinase expression and Th17/Treg cell ratio in hyperoxia-induced bronchopulmonary dysplasia in neonatal rats [0.03%]
关于高氧致支气管肺发育不良的新生大鼠IL-2诱导型酪氨酸激酶表达及Th17/Treg细胞比例观察
Xiaoxia Gong,Xingmeng Fu,Tianyi Wu et al.
Xiaoxia Gong et al.
Background: The pathogenesis of bronchopulmonary dysplasia (BPD) is not fully understood, and there is currently a lack of effective therapeutic options. The immune responses of Th17 and Treg cells are regulated by the IL...