Syndromic forms of inherited retinal dystrophies: a comprehensive molecular diagnosis of consanguineous Pakistani families using capture panel sequencing [0.03%]
捕获面板测序在巴基斯坦近亲婚配家庭遗传性视网膜营养不良综合征的分子诊断中的应用
Aleesha Asghar,Sumbal Wazir,Shehzeen Fatima et al.
Aleesha Asghar et al.
Background: Inherited retinal dystrophies (IRDs) represent a clinically and genetically heterogeneous group of genetic disorders that involve photoreceptors and/or retinal pigment epithelium degeneration. IRDs may occur a...
Subclinical parents assist in the detection of genetic variants in keratoconus by trio-based whole-exome sequencing [0.03%]
亚临床父母通过基于三代的全外显子测序协助检测圆锥角膜中的基因变异
Xingyong Li,Yinghao Yao,Shilai Xing et al.
Xingyong Li et al.
Purpose: To explore the genetic variants of 14 keratoconus trios containing subclinical parents. Methods: Trio-based whole-exome sequen...
An improved method of transducing retinal ganglion cells using AAV via transpupillary injection in adult mouse eyes [0.03%]
通过改进的AAV瞳孔注射法有效传导成年小鼠视网膜神经节细胞的方法
Fangyu Lin,Su-Ting Lin,Jiaxing Wang et al.
Fangyu Lin et al.
Purpose: Intravitreal injection of adeno-associated virus (AAV) vectors is a good approach for transducing retinal ganglion cells (RGCs) in mice. It allows for high transduction efficiency and is relatively specific to RG...
Identification of genetic factors underlying severe retinopathy of prematurity in preterm infants [0.03%]
早产儿严重视网膜病变的遗传因素识别
Huiqing Sun,Zhiyi Xia,Mingchao Li et al.
Huiqing Sun et al.
Objective: Retinopathy of prematurity (ROP) is a pathological condition characterized by abnormal proliferation of retinal vessels and it represents the primary cause of visual impairment in preterm infants. There is incr...
Serum pro-brain natriuretic peptide correlates with optical coherence tomography indices in diabetic retinopathy [0.03%]
血清前脑利钠肽与糖尿病视网膜病变的相干光断层扫描指标相关
Shivani Chaturvedi,Sandeep Saxena,Apjit Kaur et al.
Shivani Chaturvedi et al.
Purpose: Serum pro-brain natriuretic peptide (BNP) is a 108-amino-acid prohormone that inhibits vascular endothelial growth factor (VEGF) secretion, protecting pericytes from cell death and decreasing retinal vascularizat...
Retinal and metabolic changes in a high-fat diet (HFD)+STZ model of Type II diabetes [0.03%]
高脂饮食（HFD）+STZ诱导的二型糖尿病模型中的视网膜和代谢变化
Stephen Phillips,Andrew Feola,Jessica Solomon et al.
Stephen Phillips et al.
While the high-dose streptozotocin (STZ; 100 mg/kg) rodent model is the gold standard in modeling Type I diabetes, models for Type II diabetes are needed for this more common form of diabetes. We investigated the retinal, cognitive, and met...
Expression of cytokines in the aqueous humor of cataract patients with pathologic myopia and simple high myopia [0.03%]
病理性近视及单纯性高度近视白内障患者房水中细胞因子的表达
Xue Han,Yaru Hu,Yue Chen et al.
Xue Han et al.
Purpose: To explore the role of cytokines during the progression process of cataract patients with pathologic myopia (PMC) and simple high myopia (SHMC). ...
Exploring the protective effects of vasoactive intestinal peptides on dry eye disease in SARS-CoV-2 survivors [0.03%]
血管活性肠肽对新冠病毒幸存者干眼病的保护作用研究
Konstantin Y Gushansky,Raimo Tuuminen
Konstantin Y Gushansky
Purpose: This study aimed to investigate the association between proton pump inhibitors and dry eye disease (DED) among hospitalized SARS-CoV-2 patients. ...
The association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and diabetic retinopathy among patients with type 2 diabetes: A case-control study [0.03%]
内皮型一氧化氮合成酶(eNOS)基因多态性与二型糖尿病患者视网膜病变的关系：一项病例对照研究
Diala W Abu-Hassan,Muawyah D Al-Bdour,Iman Aolymat et al.
Diala W Abu-Hassan et al.
Purpose: Diabetic patients experience chronic hyperglycemia that increases oxidative stress by enhancing free radical formation and nitric oxide (NO) production. Genetic mutations in the endothelial nitric oxide synthase ...
Analysis of interleukin-6 gene polymorphism and its serum levels in Indian age-related macular degeneration patients [0.03%]
印度老年性黄斑变性患者白细胞介素6基因多态性和其血清水平的分析
Anshu Yadav,Jitender Phogat,Manoj Yadav et al.
Anshu Yadav et al.
Background: Age-related macular degeneration (AMD) is a complex condition involving multiple factors. The condition is associated with numerous inflammatory indicators, including cytokines. Single-nucleotide polymorphisms...