Mutation of beta-tubulin 4B gene (TUBB4B) causes autosomal dominant retinitis pigmentosa with sensorineural hearing loss in a multigenerational family [0.03%]
TUBB4B基因突变导致的常染色体显性视网膜色素变性和神经性耳聋家族病例研究报告
Cheryl Y Gregory-Evans,Aaron W Joe,Kevin Gregory-Evans
Cheryl Y Gregory-Evans
Purpose: Members of a multigenerational Canadian family presented to an inherited retinal degeneration (IRD) clinic with retinitis pigmentosa (RP) and sensorineural hearing loss, reminiscent of an Usher syndrome phenotype...
Inhibitory effects of ursolic acid on oxygen-induced mouse retinal neovascularization via intravitreal injection [0.03%]
熊果酸对氧诱导的小鼠视网膜新生血管化的抑制作用
Lu Yang,Fen Yang,Weiliang Zhang et al.
Lu Yang et al.
Objective: This study aimed to explore the effects and mechanisms of ursolic acid (UA) on oxygen-induced retinal neovascularization (RNV) in mice and its inhibitory effects on human retinal capillary endothelial cells (HRCECs) under high-gl...
Unravelling γD-crystallin aggregation pathway to understand cataract formation using fluorescence correlation spectroscopy [0.03%]
采用荧光相关光谱法研究γD-结晶蛋白聚集途径以理解白内障形成机制
Mangesh Bawankar,Bhaswati Sengupta,Sujata Malik et al.
Mangesh Bawankar et al.
Purpose: To characterize the aggregation behavior of the γD-crystallin protein in an acidic environment with a focus on the formation of intermediate species. The research employs fluorescence correlation spectroscopy to...
LTBP2 variants in childhood glaucoma: Phenotypic expansion and clinical experience [0.03%]
儿童青光眼中LTBP2的变异：表型和临床经验总结
Anshuman Verma,Arif O Khan,Venkatesh Pochaboina et al.
Anshuman Verma et al.
Purpose: This study describes a distinct spectrum of latent transforming growth factor-β-binding protein 2 (LTBP2)-related ocular phenotypes in pediatric glaucoma with supporting genetic evidence and highlights our clini...
Multikinase inhibition-mediated proliferative vitreoretinopathy therapy by nanoparticles in rabbits [0.03%]
用于家兔的纳米粒子介导的多激酶抑制诱导增殖性玻璃体视网膜病变疗法
Elif Arslan,Faruk Ozturk,Burcu Uner et al.
Elif Arslan et al.
Purpose: To investigate the efficacy of nanoparticles in treating proliferative vitreoretinopathy (PVR) through clinical observation, histology, and immunohistochemistry, despite unsatisfactory surgical outcomes and faile...
DNA methyltransferase 1 regulates epithelial cell functions in corneal and eyelid development [0.03%]
DNA甲基转移酶1调节角膜和眼睑发育中的上皮细胞功能
Antonius Christianto,Maureen Mongan,Bo Xiao et al.
Antonius Christianto et al.
Purpose: DNA methyltransferase 1 (DNMT1) is a crucial enzyme for the development of the retina and lens in the eye, but its roles in the cornea and eyelids are yet to be investigated. ...
Serum pro-brain natriuretic peptide correlates with optical coherence tomography indices in diabetic retinopathy [0.03%]
糖尿病视网膜病变患者血清脑利钠肽与光学相干断层扫描指标相关性研究
Shivani Chaturvedi,Sandeep Saxena,Apjit Kaur et al.
Shivani Chaturvedi et al.
Purpose: Serum pro-brain natriuretic peptide (BNP) is a 108-amino-acid prohormone that inhibits vascular endothelial growth factor (VEGF) secretion, protecting pericytes from cell death and decreasing retinal vascularizat...
Subretinal delivery of AAV5-mediated human Pde6b gene ameliorates the disease phenotype in a rat model of retinitis pigmentosa [0.03%]
AAV5介导的视紫红质6 beta亚基基因补充治疗改善夜盲症模型的有效性研究
Hee Jong Kim,Ji Hoon Kwak,Jun Sub Choi et al.
Hee Jong Kim et al.
Purpose: A genetic disorder that affects the beta subunit of cyclic guanosine monophosphate-phosphodiesterase type 6 (PDE6B) in humans leads to autosomal recessive retinitis pigmentosa (RP). This condition causes severe v...
Astragaloside IV improves the survival rates of retinal ganglion cells in traumatic optic neuropathy by regulating autophagy mediated by the AMPK-MTOR-ULK signaling pathway [0.03%]
AST-IV通过调节AMPK-MTOR-ULK信号通路介导的自噬改善视神经创伤性损伤后视网膜ganglion细胞的存活率
Wu Sun,Guojun Chao,Qiong Wu et al.
Wu Sun et al.
Purpose: Autophagy is involved in the pathological changes of traumatic optic neuropathy (TON), and the regulation of autophagy mediated by the AMPK-mTOR-ULK pathway is a potential therapeutic approach. Astragaloside IV (...