Whole exome sequencing revealed novel pathogenic variants in Vietnamese patients with FEVR [0.03%]
全外显子组测序发现越南FEVR患者中的新致病突变
Duong Thu Trang,Nguyen Minh Phu,Do Manh Hung et al.
Duong Thu Trang et al.
Background: Familial exudative vitreoretinopathy (FEVR) is a rare inherited disorder marked by incomplete retinal vascularization associated with exudation, neovascularization, and tractional retinal detachment. FEVR is g...
Analysis of hemopexin plasma levels in patients with age-related macular degeneration [0.03%]
年龄相关性黄斑变性患者的血浆血色素输蛋白水平分析
Susette Lauwen,Bjorn Bakker,Eiko K de Jong et al.
Susette Lauwen et al.
Purpose: A protein quantitative trait locus (pQTL) analysis recently revealed a strong association between hemopexin (HPX) levels and genetic variants at the complement factor H (CFH) locus. In this study, we aimed to det...
Psychological stress induces moderate pathology in the ganglion cell layer in mice [0.03%]
心理压力可诱发小鼠节细胞层中度病理变化
Dandan Zhang,Nannan Sun,Congcong Guo et al.
Dandan Zhang et al.
Purpose: Primary open-angle glaucoma (POAG) is a condition with unclear pathogenesis. Researchers have observed an increased incidence of young Chinese POAG patients who manifest significant psychological stress while the...
Safety evaluation and pharmacodynamics of minocycline hydrochloride eye drops [0.03%]
盐酸米诺环素滴眼液的安全性评价及其药效学研究
Xiaoli Li,Wenhua Zhang,Zhiqiang Ye et al.
Xiaoli Li et al.
Purpose: This study evaluated the safe dosage of minocycline hydrochloride (Mino) eye drops and investigated the potential for the prevention or reduction of retinal damage in a diabetic rat model. ...
Neural differentiation of human retinal pigment epithelial cells on alginate/gelatin substrate [0.03%]
人视网膜色素上皮细胞在藻酸盐/明胶基底上的神经分化
Hoda Shamsnajafabadi,Zahra-Soheila Soheili,Shahram Samiee et al.
Hoda Shamsnajafabadi et al.
Purpose: The development of biomaterials provides potent promise for the regeneration of neuroretinal cells in degenerative eye diseases and retinal tissue engineering. Biomimetic three-dimensional (3D) microenvironments ...
In vitro induction and intraocular application in oxygen-induced retinopathy of adipose-derived mesenchymal stem cells [0.03%]
脂肪来源的间充质干细胞在体外诱导及氧诱导视网膜病变眼内的应用
Lvlv Zhou,Haifeng Zhang,Sarina Wu et al.
Lvlv Zhou et al.
Purpose: We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. ...
Lipoxin A4 alleviates inflammation in Aspergillus fumigatus- stimulated human corneal epithelial cells by Nrf2/HO-1 signaling pathway [0.03%]
脂氧素A4通过Nrf2/HO-1信号通路缓解烟曲霉刺激的人角膜上皮细胞的炎症反应
Xudong Peng,Xiaojia Zhu,Junjie Luan et al.
Xudong Peng et al.
Purpose: To investigate the therapeutic effect of lipoxin A4 (LXA4) on Aspergillus fumigatus (A. fumigatus)-stimulated human corneal epithelial cells (HCECs). ...
αA and αB peptides from human cataractous lenses show antichaperone activity and enhance aggregation of lens proteins [0.03%]
来自人白内障透镜的αA和αB肽显示出抗分子伴侣活性并增强透镜蛋白聚集
Om Srivastava,Landon Wilson,Stephen Barnes et al.
Om Srivastava et al.
Purpose: To identify and characterize properties of αA- and αB-crystallins' low molecular weight peptides (molecular weight [Mr] < 5 kDa) that were present in a 62-year-old human nuclear cataract, but not in normal 62-y...
Morphological, biochemical, and transcriptomic characterization of iPSC-derived human RPE cells from normal and Smith-Lemli-Opitz syndrome patients [0.03%]
来自正常人和Smith-Lemli-Opitz综合征患者的iPSC来源的人RPE细胞的形态学，生化和转录组特征分析
Michael H Farkas,Lara A Skelton,Sriganesh Ramachandra-Rao et al.
Michael H Farkas et al.
A five-year follow-up of ABCA4 carriers showing deterioration of retinal function and increased structural changes [0.03%]
ARCA4携带者五年随访研究显示视网膜功能下降和结构改变增加
Ulrika Kjellström,Sten Andréasson
Ulrika Kjellström
Purpose: To investigate whether the reduced retinal function and morphological retinal changes previously demonstrated in ABCA4 carriers had remained stationary or had deteriorated over time at 5-year follow-up to further...