Role of hypoxia-inducible factor-1α in preconditioning-induced protection of retinal ganglion cells in glaucoma [0.03%]
缺血预处理通过HIF-1α保护青光眼视网膜神经节细胞的作用研究
Yanli Zhu,Lihong Zhang,Jeffrey M Gidday
Yanli Zhu
Purpose: We recently demonstrated in a mouse model of glaucoma that endogenous epigenetic mechanisms can be activated by a repetitive hypoxic preconditioning (RHP) stimulus to provide robust retinal ganglion cell (RGC) pr...
Simple fixation and storage protocol for preserving the internal structure of intact human donor lenses and extracted human nuclear cataract specimens [0.03%]
一种简单的眼内固定和储存的方案可以用来保存完整的人体捐赠晶状体和人核白内障提取标本的内部结构
Ashik Mohamed,Kurt O Gilliland,Sangeetha Metlapally et al.
Ashik Mohamed et al.
Purpose: Increased use of phacoemulsification procedures for cataract surgeries has resulted in a dramatic decrease in the availability of cataractous nuclear specimens for basic research into the mechanism of human catar...
Point mutations associated with Leber hereditary optic neuropathy in a Latvian population [0.03%]
拉脱维亚人群中的莱伯遗传性视神经病变相关点突变分析
Aleksandra Aitullina,Kristine Baumane,Solveiga Zalite et al.
Aleksandra Aitullina et al.
Purpose: To study mutations associated with Leber hereditary optic neuropathy (LHON) in patients suspected of having this mitochondrial disorder in a Latvian population. Additional aims were to determine the heteroplasmy ...
A novel donor splice-site mutation of major intrinsic protein gene associated with congenital cataract in a Chinese family [0.03%]
家系遗传性先天性白内障患者的major intrinsic protein基因供体剪接位点的新突变
Lu Zeng,Wenqiang Liu,Wenguo Feng et al.
Lu Zeng et al.
Purpose: To identify the disease-causing gene in a Chinese family with autosomal dominant congenital cataract. Methods: Clinical and op...
Amniotic fluid promotes the appearance of neural retinal progenitors and neurons in human RPE cell cultures [0.03%]
胎盘液可促进人脉状视网膜色素上皮细胞系中神经视网膜祖细胞及神经元的形成
Maliheh Davari,Zahra-Soheila Soheili,Hamid Ahmadieh et al.
Maliheh Davari et al.
Purpose: Retinal pigment epithelial (RPE) cells are capable of differentiating into retinal neurons when induced by the appropriate growth factors. Amniotic fluid contains a variety of growth factors that are crucial for ...
Association study of fibroblast growth factor 10 (FGF10) polymorphisms with susceptibility to extreme myopia in a Japanese population [0.03%]
成纤维细胞生长因子10多态性与日本人极高度近视关联的候选基因研究
Masao Yoshida,Akira Meguro,Eiichi Okada et al.
Masao Yoshida et al.
Purpose: The fibroblast growth factor 10 (FGF10) gene polymorphism rs339501 was previously reported to be associated with high myopia in a Chinese population. In the present study, we investigated whether FGF10 polymorphi...
Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5 [0.03%]
视网膜色素上皮蛋白65kD基因连锁视网膜变性不受鸡酸性亮氨酸- rich表皮生长因子样结构城含脑蛋白/神经营养蛋白C/硫酸软骨素糖蛋白5的调节
Sandra Cottet,René Jüttner,Nathalie Voirol et al.
Sandra Cottet et al.
Purpose: To analyze in vivo the function of chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C (gene symbol: Cspg5) during retinal degeneration in the Rpe65⁻/⁻ mouse m...
Measurement of tumor necrosis factor-alpha, interleukin-6, Fas ligand, interleukin-1α, and interleukin-1β in the aqueous humor of patients with open angle glaucoma using multiplex bead analysis [0.03%]
应用多重珠链式测定法检测开角型青光眼患者房水中肿瘤坏死因子、白细胞介素-6、Fas配体、白细胞介素-1α及白细胞介素-1β水平
Andreas Borkenstein,Christoph Faschinger,Richard Maier et al.
Andreas Borkenstein et al.
Purpose: Various cytokines, including tumor necrosis factor-alpha (TNF-α), Fas ligand (FasL), interleukin-1α (IL-1α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), contribute to the pathogenesis of primary open a...
Identification of the forkhead transcriptional factor 2 (FOXL2) gene mutations in four Chinese families with blepharophimosis syndrome [0.03%]
4个中国BPES家系的FOXL2基因突变检测
Li Zhang,Liming Wang,Ruifang Han et al.
Li Zhang et al.
Purpose: To determine the genetic origin of disease in four Chinese families with blepharophimosis syndrome. Methods: Four Han Chinese ...
Altered gene expression in dry age-related macular degeneration suggests early loss of choroidal endothelial cells [0.03%]
干燥性年龄相关性黄斑变性的基因表达改变提示脉络膜内皮细胞的早期丢失
S Scott Whitmore,Terry A Braun,Jessica M Skeie et al.
S Scott Whitmore et al.
Purpose: Age-related macular degeneration (AMD) is a major cause of blindness in developed countries. The molecular pathogenesis of early events in AMD is poorly understood. We investigated differential gene expression in...