Cytokines and chemokines involved in HLA-B27-positive ankylosing spondylitis-associated acute anterior uveitis [0.03%]
与HLA-B27阳性强直性脊柱炎相关的急性前葡萄膜炎的细胞因子和趋化因子
Huan Li,Zhaoxia He,Bolin Deng et al.
Huan Li et al.
Purpose: Acute anterior uveitis (AAU) is the most common extra-articular symptom of ankylosing spondylitis (AS). This study aims to reveal the cytokines and chemokines involved in the immunopathogenesis of human leucocyte...
Suppressor of cytokine signaling 3-derived peptide as a therapeutic for inflammatory and oxidative stress-induced damage to the retina [0.03%]
细胞因子信号转导抑制蛋白3衍生的肽作为治疗由炎症和氧化应激引起的视网膜损伤的疗法
Chulbul M Ahmed,Anil P Patel,Howard M Johnson et al.
Chulbul M Ahmed et al.
Purpose: Inflammation and oxidative stress contribute to age-related macular degeneration (AMD) and other retinal diseases. We tested a cell-penetrating peptide from the kinase inhibitory region of an intracellular checkp...
Therapeutic effects of a novel venom abstract (ZK002) solution in an alkali-burned corneal wound-healing model [0.03%]
新型毒液提取物(ZK002)溶液在碱烧伤角膜创面修复模型中的治疗作用研究
Wen-Yan Peng,Fei Wang,Shuang-Jian Yang et al.
Wen-Yan Peng et al.
Purpose: Corneal alkali burns can progress to corneal epithelial defects, inflammation, scarring, and angiogenesis, potentially leading to blindness. Therefore, we examined the therapeutic effects of a novel ophthalmic so...
Sulforaphane inhibits TGF-β-induced fibrogenesis and inflammation in human Tenon's fibroblasts [0.03%]
硫代葡萄糖抑制人坦恩氏纤维细胞中的TGF-β诱导的纤维增生和炎症反应
Yang Liu,Yangbin Huang,Zihan Guo et al.
Yang Liu et al.
Purpose: Subconjunctival fibrosis is the main cause of failure after glaucoma filtration surgery. We explored the effects of sulforaphane (SFN) on the conversion of human Tenon's fibroblasts (HTFs) into myofibroblasts, tr...
Novel pathogenic variants in Tubulin Tyrosine Like 5 (TTLL5) associated with cone-dominant retinal dystrophies and an abnormal optical coherence tomography phenotype [0.03%]
与视锥细胞优势性视网膜营养不良和异常的光学相干断层扫描表型有关的新型病原体变种 Tubulin Tyrosine Like 5 (TTLL5)
Olubayo U Kolawole,Cheryl Y Gregory-Evans,Riyaz Bikoo et al.
Olubayo U Kolawole et al.
Purpose: Autosomal recessive cone and cone-rod dystrophies (CD/CRD) are inherited forms of vison loss. Here, we report on and correlate the clinical phenotypes with the underlying genetic mutations. ...
Evaluation of the effects of latanoprost and benzalkonium chloride on the cell viability and nonpolar lipid profile produced by human meibomian gland epithelial cells in culture [0.03%]
拉坦前列素和苯扎氯铵对培养的人眼睑板腺上皮细胞的活力及非极性脂质谱的影响评估
Jillian F Ziemanski,Landon Wilson,Stephen Barnes et al.
Jillian F Ziemanski et al.
Purpose: The purpose of this study was to explore the effects of a PGF2α analog, latanoprost, and its preservative, benzalkonium chloride (BAK), on the cell viability and lipidomic expression of immortalized human meibom...
Protein modeling and in silico analysis to assess pathogenicity of ABCA4 variants in patients with inherited retinal disease [0.03%]
蛋白质建模和计算机模拟分析用于评估遗传性视网膜疾病患者ABCA4变异的致病性
Senem Cevik,Nutsuchar Wangtiraumnuay,Kristof Van Schelvergem et al.
Senem Cevik et al.
Purpose: The retina-specific ABCA transporter, ABCA4, plays an essential role in translocating retinoids required by the visual cycle. ABCA4 genetic variants are known to cause a wide range of inherited retinal disorders,...
Timolol maleate, a β blocker eye drop, improved edema in a retinal vein occlusion model [0.03%]
马来酸噻吗洛尔眼药水可改善视网膜静脉阻塞模型中的水肿
Shinichiro Fuma,Yae Hidaka,Anri Nishinaka et al.
Shinichiro Fuma et al.
Purpose: To investigate the therapeutic effects of eye drops, namely, timolol maleate, a β-adrenergic receptor antagonist, and latanoprost, a prostaglandin F2α analog, on retinal edema in a murine retinal vein occlusion...
Identification and phenotypic analysis of novel LTBP2 mutations in a Chinese cohort with congenital ectopia lentis [0.03%]
中国先天性晶状体异位队列中LTBP2新突变的鉴定和表型分析
Liyan Liu,Dongwei Guo,Fengmei Yang et al.
Liyan Liu et al.
Purpose: To evaluate the frequency of LTBP2 mutations and to elaborate on LTBP2-related clinical phenotypes in a Chinese congenital ectopia lentis (CEL) cohort. ...
The apoptotic and anti-proliferative effect of Lysyl oxidase propeptide in Y79 human retinoblastoma cells [0.03%]
前肽对Y79人视网膜母细胞瘤细胞的凋亡和抗增殖作用
Nareshkumar Ragavachetty Nagaraj,Sulochana Konerirajapuram Natarajan,Coral Karunakaran
Nareshkumar Ragavachetty Nagaraj
Purpose: Retinoblastoma (RB) caused by the mutation of the RB1 gene is one of the most common ocular malignancies in children The propeptide region of lysyl oxidase (LOX), the enzyme involved in the cross-linking of colla...