Bushra Hayat,Debasmita Pankaj Alone
Bushra Hayat
Background: Proteostasis impairment is central to cellular dysfunction in protein aggregation disorders such as Alzheimer disease, Parkinson disease, and age-related macular degeneration. Pseudoexfoliation (PEX), a system...
Review
Molecular vision. 2025 Nov 17:31:463-484. DOI: 2025
Genetic and clinical characterization of suspected retinitis pigmentosa in a cohort of Brazilian patients [0.03%]
Sarah Pereira de Freitas Cenachi,Maria Frasson,Anna Laura Marques Nascentes et al.
Sarah Pereira de Freitas Cenachi et al.
Purpose: To identify causative genetic variants and associated clinical phenotypes in patients of a tertiary referral center in Brazil with suspected retinitis pigmentosa (RP). ...
Jessica K Niggel,Gustavo D Aguirre,Leonardo Murgiano
Jessica K Niggel
Purpose: In the premolecular era, mammalian samples were embedded in epoxy resin blocks, such as Epon or Poly/Bed, for future evaluation by electron microscopy. However, use of these archival specimens for more modern mut...
Genetic variants through exome sequencing in Spanish patients affected by primary congenital glaucoma and juvenile open-angle glaucoma [0.03%]
Javier Laguna,Sara Labay-Tejado,Míriam Potrony et al.
Javier Laguna et al.
Purpose: To evaluate the genetic characteristics using whole-exome sequencing (WES), aiming to assess the potential of this approach for accurate diagnoses and to explore the genetic factors underlying these conditions. ...
The genotype-phenotype association of retinitis pigmentosa in a Chinese population: Analysis of three new cases and literature review [0.03%]
Jianing Liu,Mengmeng Han,Xiao Zhang et al.
Jianing Liu et al.
Purpose: Retinitis pigmentosa (RP) is an inherited heterogeneous neurodegenerative retinal disease leading to blindness eventually. Currently, a large number of studies have explored its heterogeneity, but the genotype-ph...
Review
Molecular vision. 2025 Sep 28:31:282-295. DOI: 2025
Cassia polysaccharides can regulate the effect of low PAX6 expression on the function of ARPE-19 cells through the Wnt/β-catenin pathway [0.03%]
Luo Jincheng,Li Doudou,Li Jialin et al.
Luo Jincheng et al.
Purpose: To explore the protective effects of cassia polysaccharides on myopia by examining their influence on ARPE-19 cells with reduced PAX6 expression. ...
SNTB1 gene polymorphisms and risk of high myopia: meta-analysis and single-center validation [0.03%]
Jie Peng,Yina Wang,Jiaqing Lu et al.
Jie Peng et al.
Purpose: Genetic polymorphisms in syntrophin beta-1 (SNTB1) have been implicated in altering protein function or expression, potentially influencing ocular growth regulation. Genome-wide association studies (GWASs) sugges...
Meta-Analysis
Molecular vision. 2025 Dec 30:31:570-582. DOI: 2025
Vitreous from patients with proliferative diabetic retinopathy induced changes in neutrophil activation markers [0.03%]
Fátima Sofía Magaña-Guerrero,Alan Chew Bonilla,Beatriz Buentello-Volante et al.
Fátima Sofía Magaña-Guerrero et al.
Purpose: Diabetic retinopathy (DR), a microangiopathic complication of diabetes mellitus, is a leading cause of vision loss in working-age adults and older individuals. While the etiology of DR is not fully understood, it...
Ginger extract and selenium supplementation: A promising approach to improve diabetic retinopathy [0.03%]
Xiaohan Huang,Jing Li,Shaohua Tang et al.
Xiaohan Huang et al.
Purpose: Diabetic retinopathy results from damage to small blood vessels and retinal neurons due to the overproduction of reactive oxygen species and overexpression of TRPM2 and TRPV1. Hence, inhibition of these events by...
Krishna Kalyan Kalahasti,Pandarinath Savitikadi,Ch Uday Kumar et al.
Krishna Kalyan Kalahasti et al.
Purpose: Diabetic retinopathy (DR), a severe microvascular complication of both type 1 and type 2 diabetes, is one of the leading causes of blindness. Prolonged hyperglycemia leads to vascular endothelial changes, inflamm...