Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway [0.03%]
polβ/XRCC1相互作用变异体对碱基切除修复途径中DNA连接酶IIIα的切口封尾效率的影响
Danah Almohdar,Mitchell Gulkis,Abigail Ortiz et al.
Danah Almohdar et al.
Base excision repair (BER) requires a coordination from gap filling by DNA polymerase (pol) β to subsequent nick sealing by DNA ligase (LIG) IIIα at downstream steps of the repair pathway. X-ray cross-complementing protein 1 (XRCC1), a no...
Multifaceted photoreceptor compositions in dual phototrophic systems - A genomic analysis [0.03%]
双光合系统中的多功能感光受体组成成分－基因组分析
Janne A Ihalainen,Batuhan Dogan,Moona Kurttila et al.
Janne A Ihalainen et al.
For microbes and their hosts, sensing of external cues is essential for their survival. For example, in the case of plant associated microbes, the light absorbing pigment composition of the plant as well as the ambient light conditions dete...
Structure of the Portal Complex from Staphylococcus aureus Pathogenicity Island 1 Transducing Particles In Situ and In Isolation [0.03%]
来自金黄色葡萄球菌毒力岛1转导颗粒原位及分离后的门户复合体结构
Amarshi Mukherjee,James L Kizziah,N&#x;Toia C Hawkins et al.
Amarshi Mukherjee et al.
Staphylococcus aureus is an important human pathogen, and the prevalence of antibiotic resistance is a major public health concern. The evolution of pathogenicity and resistance in S. aureus often involves acquisition of mobile genetic elem...
Molecular Determinants of PQBP1 Binding to the HIV-1 Capsid Lattice [0.03%]
PQBP1与HIV-1衣壳晶格结合的分子决定因素
Juliana Piacentini,Dale S Allen,Barbie K Ganser-Pornillos et al.
Juliana Piacentini et al.
Human immunodeficiency virus type 1 (HIV-1) stimulates innate immune responses upon infection, including cyclic GMP-AMP synthase (cGAS) signaling that results in type I interferon production. HIV-1-induced activation of cGAS requires the ho...
One More for Light-triggered Conformational Changes in Cryptochromes: CryP from Phaeodactylum tricornutum [0.03%]
蓝光诱发隐花色素构象变化再添新成员：三角褐指藻CryP蛋白
Martin Saft,Leonie Schneider,Chun-Chih Ho et al.
Martin Saft et al.
Cryptochromes are a ubiquitously occurring class of photoreceptors. Together with photolyases, they form the Photolyase Cryptochrome Superfamily (PCSf) by sharing a common protein architecture and binding mode of the FAD chromophore. Despit...
Photosystem II Subunit S (PsbS): A Nano Regulator of Plant Photosynthesis [0.03%]
光系统II复合物S(PsbS)：植物光合作用的纳米调节因子
Willem Marulanda Valencia,Anjali Pandit
Willem Marulanda Valencia
Light is required for photosynthesis, but plants are often exposed to excess light, which can lead to photodamage and eventually cell death. To prevent this, they evolved photoprotective feedback mechanisms that regulate photosynthesis and ...
Brenda L Rojas,Emmanuel Vazquez-Rivera,Carrie L Partch et al.
Brenda L Rojas et al.
The PAS (PER, ARNT, SIM) protein family plays a vital role in mammalian biology and human disease. This analysis arose from an interest in the signaling mechanics by the Ah receptor (AHR) and the Ah receptor nuclear translocator (ARNT). Aft...
β-Strand-mediated Domain-swapping in the Absence of Hydrophobic Core Repacking [0.03%]
无疏水核心重组的β-折叠介导的结构域互换现象
Mikoto Kiya,Shota Shiga,Peiwei Ding et al.
Mikoto Kiya et al.
Domain swapping is a process wherein a portion of a protein is exchanged with its counterpart in another copy of the molecule, resulting in the formation of homo-oligomers with concomitant repacking of a hydrophobic core. Here, we report do...
Gauging Dynamics-driven Allostery Using a New Computational Tool: A CAP Case Study [0.03%]
一种新的计算工具评估动态诱导别构效应：CAP为例
Alexandr P Kornev,Jui-Hung Weng,Rodrigo A Maillard et al.
Alexandr P Kornev et al.
In this study, we utilize Protein Residue Networks (PRNs), constructed using Local Spatial Pattern (LSP) alignment, to explore the dynamic behavior of Catabolite Activator Protein (CAP) upon the sequential binding of cAMP. We employed the D...
Mechanisms of DNA Methylation Regulatory Function and Crosstalk with Histone Lysine Methylation [0.03%]
DNA甲基化调控功能及其与组蛋白赖氨酸甲基化的相互作用机制研究进展
Bailey M Tibben,Scott B Rothbart
Bailey M Tibben
DNA methylation is a well-studied epigenetic modification that has key roles in regulating gene expression, maintaining genome integrity, and determining cell fate. Precisely how DNA methylation patterns are established and maintained in sp...