The Cancer Noise Atlas (TCNA): A Webserver of Multiscale Transcriptional Noise in Cancer [0.03%]
癌症噪声图谱（TCNA）：癌症转录噪声的多尺度网站服务器
Rubab Shah,Aleema Faisal,Abdullah Bin Faiz et al.
Rubab Shah et al.
Cancer cells are characterized by highly divergent gene expression, resulting in expression heterogeneity in tumors, which contributes to variable therapeutic responses. The advent of next-generation sequencing has enabled the elucidation o...
Molecular Determinants of Response and Rational Drug Combinations for Antibody-Drug Conjugates (ADCs) with Topoisomerase I (TOP1) Inhibitor payloads [0.03%]
抗体偶联药物(ADC)治疗的分子决定因素及拓扑异构酶I(TOP1)抑制剂载荷的合理联合用药分子决定因素及拓扑异构酶I(TOP1)抑制剂载荷的合理联合用药
Yves Pommier
Yves Pommier
Here we describe the different TOP1 poisons used a "payload" for tumor-targeted anticancer therapies in comparison with the widely used first generation TOP1 poisons: Topotecan, Irinotecan and Belotecan. We review the determinants of respon...
MoonProt 4.0: 2026 Update of the Moonlighting Proteins Database [0.03%]
月光蛋白数据库MoonProt 4.0：2026更新版本
Aini Asif,Nour Farache,Wael Farache et al.
Aini Asif et al.
MoonProt 4.0 (http://moonlightingproteins.org) is an updated open-access database storing manually-curated annotations for moonlighting proteins. Moonlighting proteins exhibit two or more physiologically relevant distinct biochemical or bio...
Eunseok Kang,Hyunwoo C Kwon,Seung-Jae V Lee
Eunseok Kang
Aging is a complex biological process that gradually increases vulnerability to death and susceptibility to age-related diseases. Emerging evidence indicates that nonsense-mediated mRNA decay (NMD), a conserved RNA surveillance pathway in e...
Multifaceted Roles of the NLRC4 Inflammasome in Cancer: From Molecular Mechanisms to Therapeutic Implications [0.03%]
NLRC4炎症小体在癌症中的多面作用：从分子机制到治疗意义
Zhen Zhang,Yang Li,Zhimeng Lv et al.
Zhen Zhang et al.
NLRC4 forms an inflammasome complex and activates a critical innate immune response to bacterial infection. The NLRC4 inflammasome triggers the activation of the cysteine protease caspase-1, leading to the proteolytic maturation of the pro-...
Translatable Circular RNAs are Degraded Via Nonsense-mediated mRNA Decay [0.03%]
可翻译的环状RNA通过无义介导的mRNA降解被降解
Eunchae Kang,Dahyeon Kang,Yeo Kyung Cho et al.
Eunchae Kang et al.
Endogenous circular RNAs (circRNAs) are predominantly generated by a back-splicing process. Due to their lacking 5' and 3' termini, circRNA degradation is exclusively dependent on endoribonucleolytic cleavage. In addition, translation occur...
Structural Insights into Tanc1/2 Autoinhibition and Their Implications for NDD Pathogenesis [0.03%]
Tanc1/2自身抑制的结构见解及其在神经发育障碍发病机制中的意义
Dengqin Zhong,Chenyang Xue,Mengjie Lyu et al.
Dengqin Zhong et al.
Tanc1 and Tanc2 are synaptic scaffold proteins with high structural similarity but distinct expression patterns and functions. Although accumulating evidence points to important divergent roles of Tanc1 and Tanc2 in neural development, the ...
Evolution of Temperature Dependence of TRPM2 Channel Gating and Inactivation in Vertebrates [0.03%]
脊椎动物TRPM2通道调控和失活的温度依赖性进化
Adam Bartok,Adam V Toth,László Csanády
Adam Bartok
TRPM2 is a Ca2+ permeable cation channel activated by cytosolic Ca2+ and ADP ribose (ADPR). In contrast to invertebrate orthologs, vertebrate TRPM2 channels inactivate due to evolutionary alterations in amino acid sequence around the select...
Identification of non-basic matrix domain residues that impact HTLV-1 Gag membrane targeting and particle release [0.03%]
识别影响HTLV-1Gag膜定位和颗粒释放的非基本矩阵结构域残基
Shuyu Meng,Bao Pham,Sophie Hines et al.
Shuyu Meng et al.
The matrix (MA) domain of the Gag polyprotein is critical for directing retroviral assembly at the plasma membrane (PM), yet the determinants mediating human T-cell leukemia virus type 1 (HTLV-1) Gag targeting remain incompletely defined. W...
Molecular dissection of the UvrC protein involved in nucleotide excision repair in Listeria monocytogenes [0.03%]
李斯特菌核酸内切修复中UvrC蛋白的分子分析
Preetha C Sivadasan,Manoj Thakur,K Neelakanteshwar Patil
Preetha C Sivadasan
Nucleotide excision repair (NER) is a conserved DNA repair pathway that removes a wide range of DNA lesions and preserves genome integrity. In bacteria, this process is executed by the UvrABC excinuclease complex, in which UvrC performs dua...