Molecular insights into the binding dynamics of transcription factor TBR1 to T-box DNA sequences [0.03%]
TBR1转录因子与T盒DNA序列结合的动力学的分子机制研究
Raymond Hartman,Ashleigh Blane,Fillmon Kubrom et al.
Raymond Hartman et al.
TBR1 is a transcription factor critical for brain development that recognises a specific nucleotide sequence, the T-box binding element (TBE). Dysregulation or mutation of TBR1 is linked to a spectrum of neurodevelopmental disorders, includ...
SpatialFusion: A unified model for integrating spatial transcriptomics to unveil cell-type distribution, interaction, and functional heterogeneity in tissue microenvironments [0.03%]
空间融合模型：一种统一的空间转录组学整合模型，用于揭示组织微环境中细胞类型分布、相互作用和功能异质性
Mengqiu Wang,Zhiwei Zhang,Xinxin Zhang et al.
Mengqiu Wang et al.
Recent advances in spatial transcriptomics (ST) have significantly enhanced our understanding of tissue structure and intercellular interactions. However, existing methods for spatial domain identification and cell type deconvolution still ...
Evan Pacheco,Aron A Shoara,Logan W Donaldson
Evan Pacheco
Slf1 and Sro9 are paralogous RNA-binding proteins in Saccharomyces cerevisiae that belong to the LARP1 (La-related protein 1) subgroup of the greater La family. These proteins function as translational regulators during cellular stress, act...
On the relationship between protein stability, thermostability, and allosteric signalling [0.03%]
蛋白质稳定性、热稳定性和别构信号转导之间的关系
Raechell,Wei-Ven Tee,Bingxue Dong et al.
Raechell et al.
The thermodynamic stability of proteins and regulation of their functional activity can be described within the energy landscape framework, where the former is explained via a unique native conformational ensemble separated by an energy gap...
Structure-Based Classification of CRISPR/Cas9 Proteins: A Machine Learning Approach to Elucidating Cas9 Allostery [0.03%]
基于结构的CRISPR / Cas9蛋白分类：一种机器学习方法，揭示Cas9别构性
Sita Sirisha Madugula,Vindi M Jayasinghe-Arachchige,Charlene R Norgan Radler et al.
Sita Sirisha Madugula et al.
The CRISPR/Cas9 system is a powerful gene-editing tool. Its specificity and stability rely on complex allosteric regulation. Understanding these allosteric regulations is essential for developing high-fidelity Cas9 variants with reduced off...
Both Domains of APOBEC3F Recognize AA RNA Motifs to Support HIV-1 Virion Encapsidation and Antiviral Function [0.03%]
APOBEC3F的两个结构域通过识别AA基序参与HIV-1病毒体包装和抗病毒功能
Josue Pacheco,Maria Yousefi,Hanjing Yang et al.
Josue Pacheco et al.
The anti-HIV-1 activity of the double-domain cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) depends on their encapsidation into progeny virions. While A3G requires AA-dinucleotide recognition by its N-terminal deaminase domain (CD1) ...
Ilias Zarguit,Marc K M Cajili,Bert van Erp et al.
Ilias Zarguit et al.
DNA-wrapping histone proteins play a central role in chromatin organization, gene expression and regulation in most eukaryotes and archaea. While the structure and function of eukaryotic histones are well-characterized, archaeal histones an...
HGCJAMH: A Method for circRNA-Drug Sensitivity Prediction Based on Higher-Order Moment-Guided Model and Hypergraph Jumping Learning Mechanism [0.03%]
基于高阶矩引导模型和超图跳跃学习机制的circRNA-药物敏感性预测方法:HGCJAMH
Gongwei Chen,Chang Cai,Xiaoyu Liu et al.
Gongwei Chen et al.
Circular RNAs (circRNAs) play a key role in regulating cellular drug sensitivity, and they hold significant promise as potential biomarkers in disease treatment and precision medicine. However, existing circRNA-drug sensitivity association ...
HeavyBuilder: Analysis of High-Throughput of Antibody Heavy Chain Repertoires in the Structural Space [0.03%]
重型链构建器：抗体重型链 repertoire 的高通量结构空间分析
Joao D Gervasio,Alexander Greenshields-Watson,Nele Quast et al.
Joao D Gervasio et al.
The vast majority of immunoglobulin sequence data publicly available is of antibody heavy chain-only, as it is easier and cheaper to sequence than the paired heavy and light chains. However, structural characterization and analysis of these...
Corrigendum to "Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2". [J. Mol. Biol. 433 (2021) 166980] [0.03%]
“_multidrug_外排转运蛋白ABCG2识别底物的结构基础”一文的勘误通知书
Julia Kowal,Dongchun Ni,Scott M Jackson et al.
Julia Kowal et al.
Published Erratum
Journal of molecular biology. 2025 Nov 4;437(24):169510. DOI:10.1016/j.jmb.2025.169510 2025