Unraveling the link between thermal adaptation and latent allostery in malate dehydrogenase from Methanococcales [0.03%]
甲烷杆菌纲苹果酸脱氢酶热适应与潜在别构作用之间联系的探究
Caroline Simões Pereira,Sandrine Coquille,Céline Brochier-Armanet et al.
Caroline Simões Pereira et al.
Malate dehydrogenase (MalDH) (EC.1.1.1.37) is an enzyme engaged in the central metabolism of cells, catalyzing the interconversion between oxaloacetate and malate using NADH or NADPH as coenzyme. These enzymes are particularly interesting m...
Cracking Controls ATP Hydrolysis in the catalytic unit of a P-type ATPase [0.03%]
Cracking控制P型ATP酶催化单元的ATP水解
M Agueda Placenti,Santiago A Martinez-Gache,Rodolfo M González-Lebrero et al.
M Agueda Placenti et al.
Membrane transporters are essential for homeostasis and among them P-type ATPases are key players. Despite extensive research, conformational changes in their catalytic unit and their coupling to ATP hydrolysis are not explored in detail. I...
Kaptin Functions as a Barbed-End Binding Protein to Control Actin Filament Dynamics [0.03%]
Kaptin通过结合带正电的末端控制肌动蛋白纤维动力学
Priyanka Dutta,Ipshita Maiti,Krishna Chandra Mondal et al.
Priyanka Dutta et al.
Precise regulation of the actin cytoskeleton is fundamental to cellular morphology, motility, and intracellular transport. While key classes of actin-binding proteins, including nucleators, capping proteins, and bundlers, have been well cha...
Selective eIF4E-eIF4G pairing and cap-4 recognition mechanisms in trypanosomatids: insights from EIF4E5-EIF4G1 and EIF4E6-EIF4G5 complexes [0.03%]
利什曼原虫的选择性eIF4E-eIF4G配对和cap-4识别机制：来自EIF4E5-EIF4G1和EIF4E6-EIF4G5复合物的见解
Renato Ferras Penteado,Sophie Vichier-Guerre,Beatriz Maria da Silva Pereira et al.
Renato Ferras Penteado et al.
Translation initiation in eukaryotes is a highly regulated process involving the assembly of several transient protein complexes. A key step in this process is recognition of the mRNA 5' cap structure by the initiation factor eIF4E, a core ...
Doxorubicin recognition and transport by the MATE multidrug transporter NorM from Vibrio cholerae [0.03%]
链球菌多药转运蛋白NorM识别和运输柔红霉素
Pei-Yu Hsieh,Ksenija Romane,Julia Kowal et al.
Pei-Yu Hsieh et al.
Multidrug and toxic compound extrusion (MATE) transport proteins contribute to multidrug resistance in human pathogens by extruding various cytotoxic compounds from the cellular interior. Despite their importance across all domains of life,...
Binding and translocation of substrate allosterically promotes functional interactions within the AlkB-AlkG electron transfer complex [0.03%]
底物的别构结合和跨定位促进AlkB-AlkG电子转移复合体的功能互动
Karolina Mikulska-Ruminska,Matthew Licht,Mehmed Z Ertem et al.
Karolina Mikulska-Ruminska et al.
The alkane monooxygenase AlkB and rubredoxin AlkG form an electron transfer complex that hydroxylates terminal alkanes to produce alcohols. The recent cryoEM study of Fontimonas thermophila AlkB-AlkG complex revealed its architecture, inclu...
Distinct cis-acting elements combinatorically mediate co-localization of mRNAs encoding for co-translational interactors in cytoplasmic clusters in S. cerevisiae [0.03%]
在S. cerevisiae细胞质簇中，编码共翻译相互作用蛋白的mRNA共定位的组合调控元件
Qamar Shhade,Marianna Estrada,Rawad Hanna et al.
Qamar Shhade et al.
Many newly synthesized proteins assemble co-translationally, providing a vital mechanism to prevent subunit misfolding in the crowded cytoplasm. Initial evidence indicates that the spatial organization of mRNAs aids this assembly, but it is...
Justin C Wheat,Robert A Coleman,Ulrich Steidl
Justin C Wheat
Hematopoiesis, or the process of blood production, has long served as a prototype for stem cell biology research owing to the relative ease of obtaining blood as well as functional testing in vitro and in vivo (through stem cell transplanta...
Protein intrinsic disorder and adaptation to extreme environments: Resilience of chaos [0.03%]
蛋白质内在无序性与极端环境适应性：混沌的韧性
Vladimir N Uversky
Vladimir N Uversky
Extremophiles are organisms adapted not only to survive in harsh conditions but thrive in environments considered extreme or uninhabitable by most life forms. They serve as a living reflection of a popular motto "What doesn't kill you makes...
Structural Basis of Redox-Dependent Affinities of Dihydroorotate Dehydrogenase for Its Substrates and Products [0.03%]
二氢乳清酸脱氢酶的底物和产物的氧化还原依赖性亲和力的结构基础
Osamu Tani,Tomomi Kubota,Tomoko Yamasaki et al.
Osamu Tani et al.
Dihydroorotate dehydrogenase (DHODH), containing a cofactor, flavin mononucleotide (FMN), catalyzes the oxidation of dihydroorotate to orotate. In Trypanosoma brucei, the causative parasite of African trypanosomiasis, the DHODH enzyme (TbDH...