DivideFold+: an AI-based tool for RNA secondary structure prediction with subdomains identification and visualization and data augmentation [0.03%]
DivideFold+: 基于人工智能的RNA二级结构预测工具，具备亚域识别、可视化和数据增强功能
Loïc Omnes,Eric Angel,Fariza Tahi
Loïc Omnes
Predicting the secondary structure of RNAs, particularly long RNAs, remains a challenging problem despite its importance in identifying the structural roles of RNAs. Deep-learning-based methods face a lack of data and cannot provide very ac...
Caixia Hou,Nishad Thamban Chandrika,Markos Leggas et al.
Caixia Hou et al.
Trabectedin is a DNA-binding natural product with potent anticancer activities. Trabectedin is used clinically worldwide to treat soft tissue sarcomas and ovarian cancer. A crystal structure of trabectedin in complex with DNA has been elusi...
Ensemblify: a user-friendly platform for generating and analyzing conformational ensembles of intrinsically disordered proteins and regions [0.03%]
Ensemblify：一个用于生成和分析内在无序蛋白及其区域构象系的用户友好型平台
Nuno P Fernandes,Tiago Gomes,Tiago N Cordeiro
Nuno P Fernandes
Intrinsically disordered proteins (IDPs) and regions (IDRs) challenge structural characterization due to their dynamic conformational ensembles. Existing computational approaches for modelling these ensembles are often computationally expen...
Zhengshan Hu,Unnatiben Rajeshbhai Patel,Eliezra Glasser et al.
Zhengshan Hu et al.
Small GTPases play important roles in cellular signaling. Due to their small sizes (∼21 kDa), structural studies of small GTPases have been predominantly performed using x-ray crystallography in which crystal lattice contacts made it chall...
H3K36 methylation is essential for promoter-terminator interaction and re-association of RNAPII to gene promoter during inducible transcription in yeast [0.03%]
酵母中组蛋白甲基化H3K36对于诱导转录时启动子与终止子相互作用及RNAPII重新结合到基因启动子是必需的
Priyabrata Singha,Ronita Nag Chaudhuri
Priyabrata Singha
A network of specific histone modifications is critical for chromatin modulation during DNA templated processes, including transcription. Here we unravel a novel role of H3K36 methylation that is required to augment the efficiency of induci...
Kathleen B Hall
Kathleen B Hall
Proton-Coupled Gate Closing Mechanism in Guillardia theta Anion Channelrhodopsin 1 [0.03%]
Guillardia theta厌氧通道视紫红质1的质子偶联门控机制研究
Miu Sudo,Sayo Inoko,Yuma Ito et al.
Miu Sudo et al.
Light-gated anion channelrhodopsins are widely used as optogenetic silencers, yet the molecular events underlying gate opening and closing remain unclear. Here we show that gate closure in Guillardia theta anion channelrhodopsin 1 (GtACR1) ...
A conserved 3'UTR stem-loop directs UPF1/eIF4AIII-dependent regulation of GABARAPL1 mRNA [0.03%]
保守的3′ UTR发夹结构通过UPF1/eIF4AIII调节GABARAPL1 mRNA稳定性
Chloé Mercier,Maëlys Baudin,Francesca Fiorini et al.
Chloé Mercier et al.
RNA-binding proteins (RBP) interact with mRNA untranslated regions containing cis-regulatory elements to govern mRNA localization, stability, and translational efficiency. Among these trans-regulatory factors, RNA helicase UPF1 is a central...
Conformational Analysis and Structural Characterization of Furin Inhibitors and Their Enzyme Complexes: Structural Insights into the Role of Cis/Trans Isomerization of the P2'-P3' Peptide Bond [0.03%]
furin抑制剂及其酶复合物的构象分析和结构表征：cis/trans异构化在P2'-P3'肽键中的作用的结构见解
Dawid Dębowski,Aleksandra Helbik-Maciejewska,Agata Gitlin-Domagalska et al.
Dawid Dębowski et al.
The three-dimensional structures of two novel and highly potent inhibitors of furin were characterized using NMR spectroscopy. Both compounds are cyclic peptides belonging to the Bowman-Birk family of inhibitors (BBI). In the monocyclic dis...
Cryo-EM structure of the human Mas receptor reveals N-terminal occlusion of the orthosteric ligand binding pocket [0.03%]
人类Mas受体的冷冻电镜结构揭示了正构配体结合袋的N末端遮挡现象
Shota Suzuki,Kotaro Tanaka,Kouki Nishikawa et al.
Shota Suzuki et al.
The Mas receptor (MasR) is a class A G protein-coupled receptor (GPCR) that mediates the counter-regulatory arm of the renin-angiotensin system through the ACE2-angiotensin-(1-7)-MasR axis and represents a promising therapeutic target for c...