Mingjie Zhang,Da Jia
Mingjie Zhang
Novel macrocyclic peptides as potent and selective inhibitors of human neutrophil serine protease 4 [0.03%]
新型环状多肽类人类中性粒细胞丝氨酸蛋白酶4高效抑制剂
Wanjian Tang,Mark Ultsch,Emel Adaligil et al.
Wanjian Tang et al.
Neutrophil serine protease 4 (NSP4) is the most ancient member of the NSP family, which includes neutrophil elastase, proteinase 3 and cathepsin G, but is unique in its strong preference for cleavage after an arginine residue. NSP4 is highl...
Biochemical basis for LRP1 interaction with Rift Valley fever virus glycoprotein and its role in viral entry [0.03%]
LRP1与裂谷热病毒糖蛋白的相互作用及其在病毒感染中的作用的生化基础
Farheen Fatma,David A Price,Rachael E Rush et al.
Farheen Fatma et al.
The LDL receptor related protein 1 (LRP1) is a host entry factor for Rift Valley Fever Virus (RVFV), a negative sense RNA virus in the Bunyaviricetes class within the Phenuiviridae family. Previous studies revealed that RVFV glycoproteins (...
The O‑GlcNAcase inhibition by Thiamet G disrupts the AngioMatrix signature of the Glioblastoma secretome in silico and impairs its angiogenic capacity in vitro [0.03%]
O-连接-N-乙酰半乳糖胺（O-GlcNAc）酶的抑制剂Thiamet G通过计算机模拟破坏胶质母细胞瘤分泌组中AngioMatrix的特征，并且在体外实验中损害其血管生成能力
Marcella Abranches Gil de Castro,Taina Queiroz,Aline Cristina de Menezes et al.
Marcella Abranches Gil de Castro et al.
Glioblastoma (GBM) is the most aggressive tumor in the Central Nervous System for which the standard-of-care treatment is still limited to maximal surgical resection followed by chemotherapy and radiotherapy. Thus, innovative strategies hav...
Uncompetitive Allosteric Inhibitor of Mitochondrial Creatine Kinase Prevents Binding and Release of Creatine by Stabilization of Loop Closure [0.03%]
不具竞争性的线粒体肉毒碱磷酸酶异 allosteric抑制剂通过稳定环闭合来防止肉毒碱的结合和释放
Merve Demir,Chen-Ting Ma,Nikhil Puvvula et al.
Merve Demir et al.
Mitochondrial creatine kinase (MtCK) is a key enzyme in energy buffering and homeostasis in cells. It catalyzes transfer of phosphoryl group from ATP to creatine. Overexpression of MtCK occurs in many cancer cells to meet elevated energy de...
iKa/Ks: Estimating the Selection Pressure and Evolutionary Rate of Proteins under the Non-neutral Hypothesis of Synonymous Mutations [0.03%]
iKa/Ks：基于同义突变非中性假说的蛋白质选择压及进化速率估计方法
Jiachen Ye,Chunmei Cui,Rui Fan et al.
Jiachen Ye et al.
The Nonsynonymous/Synonymous substitution rate ratio (Ka/Ks) is a widely used metric to estimate the selection pressure and evolutionary rate of proteins in comparative genomics. A key assumption of Ka/Ks is that synonymous mutations are ev...
Mechanistic origins and evolutionary erosion of collateral sensitivity in a β-lactamase [0.03%]
β-内酰胺酶中偶联敏感性的机制起源及其在进化中的侵蚀现象
Daniel Salamonsen,Karol Buda,Daojiong Wang et al.
Daniel Salamonsen et al.
As antibiotic discovery stalls, exploiting collateral sensitivity, where resistance to one drug increases sensitivity to another, offers a promising route to extend the lifespan of existing drugs. However, the molecular origins and robustne...
Chelsea A Mann,James M Dewar,Neil Osheroff
Chelsea A Mann
Antibacterial agents have transformed modern medicine. However, the rise of antimicrobial resistance threatens these advances, creating an urgent need for new antibacterial classes with novel mechanisms of action to be developed. The bacter...
Disordered Tails Shape DNA Specificity of Myc:Max via Transient Competition [0.03%]
无序尾部通过瞬时竞争来塑造Myc:Max的DNA特异性
Shira Peer,Yaakov Levy
Shira Peer
Intrinsically disordered regions (IDRs) are ubiquitous in eukaryotic transcription factors, yet the high prevalence of negatively charged IDRs presents a biophysical paradox due to their expected electrostatic repulsion from the DNA backbon...
Interaction of bacterial histidine phosphatase SixA with phosphocarrier protein NPr and phosphohistidine analogs [0.03%]
SixA组氨酸磷酸酶与NPr蛋白和组氨酸磷酸类似物之间的相互作用
James M Gruschus,Eric Lindberg,Guillermo A Bermejo et al.
James M Gruschus et al.
SixA is a phosphatase that dephosphorylates phosphohistidine in proteins involved in signaling in bacteria. Using NMR spectroscopy, the interaction of SixA was structurally characterized with one of its functional substrates, the phosphocar...