Antibody-secreting cells integrate efficient NMD with non‑canonical UPR signaling to maintain proteostasis and support massive immunoglobulin synthesis [0.03%]
抗体分泌细胞整合高效NMD与非经典UPR信号传导以维持蛋白稳态并支持大量免疫球蛋白合成
Praité Antoine,Lambert Jean-Marie,Ashi Mohamad Omar et al.
Praité Antoine et al.
Plasma cells are terminally differentiated B lymphocytes specialized in the high‑level production and secretion of antibodies. To accommodate the persistent load imposed on the endoplasmic reticulum (ER), plasma cell differentiation engage...
Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry [0.03%]
氢氘交换质谱法揭示小分子稳定多种免疫球蛋白轻链淀粉样原物
Daniele Peterle,Nicholas L Yan,Elena S Klimtchuk et al.
Daniele Peterle et al.
Immunoglobulin light chains, a component of antibodies, can misfold and aggregate to cause systemic AL amyloidosis. Aggregation, including amyloid fibril formation, requires unfolding of the full-length light chain from its native state, an...
UPF1 at Work: Structural and Mechanistic Insights into a Master Regulator of Nonsense-Mediated mRNA Decay [0.03%]
UPF1的工作原理：无意义介导的mRNA降解主调节因子的结构和机制见解
Vincent Mocquet,Francesca Fiorini
Vincent Mocquet
RNA helicases are central architects of ribonucleoprotein (RNP) organization, coupling nucleoside triphosphate hydrolysis to RNA binding to unwind duplexes, translocate along nucleic acids, displace RNA-binding proteins, and remodel RNP ass...
Structural basis for the pro-amyloidogenic action and ligand binding of a novel W72R variant of human apolipoprotein A-I [0.03%]
人源载脂蛋白A-I新型W72R变异体促淀粉样前体作用及配体结合的结构基础
Tatiana Prokaeva,Shobini Jayaraman,Elena S Klimtchuk et al.
Tatiana Prokaeva et al.
Apolipoprotein A-I (apoA-I), the major structural and functional protein of plasma high-density lipoprotein (HDL), mediates cholesterol removal from the body and has other beneficial properties. APOA1 gene mutations can cause diseases inclu...
Cryo-EM Structure of the C. elegans Septin Tetramer Reveals a Revised Architecture and Conserved Positional Orthology [0.03%]
秀丽隐杆线虫的 septin 四聚体的低温电镜结构揭示了其新颖的构象及保守的位置同源性
Giovanna Christe Dos Reis Saladino,Heloísa Ciol,Deborah Cezar Mendonça et al.
Giovanna Christe Dos Reis Saladino et al.
Septins are cytoskeletal proteins that assemble into hetero-oligomeric complexes which polymerize into filaments to regulate many cellular processes, including cytokinesis and membrane remodelling. In Caenorhabditis elegans, the core septin...
Allosteric targeting of the ACE2 dimer interface by a medium-sized compound inhibits SARS-CoV-2 entry [0.03%]
一种中等大小化合物通过靶向ACE2二聚体界面抑制SARS-CoV-2入侵
Mariko Yokogawa,Shunki Kaneichi,Mahoro Horiuchi et al.
Mariko Yokogawa et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), enters host cells via interaction between the receptor-binding domain of the spike protein (RBDSP) and the peptidase d...
An Evolutionarily Conserved TUSC2-OSCP Interface Suggests a Mitochondrial Ca2⁺-Sensing Mechanism for ATP Synthase Regulation [0.03%]
进化上保守的TUSC2-OSCP界面提示ATP合成酶调控的线粒体钙感应机制
Sergey V Ivanov,Roman V Uzhachenko,Sergei P Budko et al.
Sergey V Ivanov et al.
Mitochondrial ATP synthase (mATPS) has the capacity to regulate the permeability transition pore (mPTP) during Ca2⁺ fluctuations. Dysregulation of this mechanism is implicated in neurodegenerative and other diseases; however, the endogenou...
Fibrillin-1 inhibits early adipogenic commitment via αvβ3 integrin signaling [0.03%]
纤连蛋白-1通过αvβ3整合素信号抑制早期脂肪细胞生成
Iram Fatima S Siddiqui,Valentin Nelea,Kerstin Tiedemann et al.
Iram Fatima S Siddiqui et al.
Extracellular fibrillin-1 is present in many tissues, including adipose tissue. Mutations in fibrillin-1 cause Marfan syndrome, paradoxically presenting with either low body fat at younger ages or frequently increased adiposity in older ind...
Microglial ITAM & ITIM signaling in neurodegenerative disease and brain aging [0.03%]
小胶质细胞ITAM和ITIM信号在神经退行性疾病和脑衰老中的作用
Aman Mangalmurti,Amelia Bonheur,John R Lukens
Aman Mangalmurti
Innate immunity within the central nervous system (CNS) plays key roles in shaping both healthy brain aging and vulnerability to neurodegenerative disease. Microglia, the tissue-resident macrophages of the CNS, play a key role in mediating ...
Rita Casadio,Zhi John Lu,David H Mathews et al.
Rita Casadio et al.