Bacterial chemoreceptors transmit stimulus signals through coupled entropic switches [0.03%]
细菌化学感受器通过耦合熵开关传递刺激信号
Caralyn E Flack,John S Parkinson
Caralyn E Flack
Tracking ligand-induced conformational changes through transmembrane sensory proteins remains a challenge in signal transduction research. Our study followed propagation of stimulus signals through a bacterial transmembrane chemoreceptor (T...
Ancestral sequence reconstruction reveals CTP-dependent loading of the bacterial centromere-binding protein ParB as an ancient evolutionary feature [0.03%]
祖先序列重建揭示细菌着丝粒结合蛋白ParB依赖CTP的加载为其古老的进化特征
Juri Hanßmann,Stefano Lometto,Wieland Steinchen et al.
Juri Hanßmann et al.
In most bacteria, chromosome and low-copy plasmid segregation are mediated by the ParABS system. Its component ParB functions as a DNA sliding clamp that assembles on centromere-like parS sites to form large nucleoprotein complexes, which a...
Repurposing Drug Explorer (ReDEx): a tool for integrating disease networks, drug similarity algorithms and functional exploration powered by Enalos Cloud Platform [0.03%]
药物再定位药物探索工具（ReDEx）：一种集成功能模块、疾病网络、药理相似性算法并由Enalos云计算平台驱动的在线分析工具
Danai Giannakou,Constantinos Papavasiliou,Danae Zareifi et al.
Danai Giannakou et al.
Drug repurposing is a widely adopted strategy aimed at identifying new therapeutic uses for drugs, offering a faster and more cost-effective alternative to traditional drug development. While the approach has gained significant traction, mo...
Metastable folding of Bacillus subtilis glmS ribozyme modulates turnover by RNase J1 [0.03%]
芽孢杆菌glmS核酶的亚稳态折叠通过RNase J1调节其周转率
Yuan Lou,Sarah A Woodson
Yuan Lou
Rapid turnover of glmS mRNA in Bacillus subtilis by 5'-3' exoribonuclease RNase J is essential for feedback regulation of glucosamine-6-phosphate (GlcN6P) synthase expression, upon self-cleavage of a GlcN6P-activated ribozyme in the glmS 5'...
Adaptation of Folding and Function of a Nuclease from the Cold Deep Sea [0.03%]
来自深海低温环境的核酸酶的适应与功能研究
Tejaswi Koduru,Philippe Barthe,Noam Hantman et al.
Tejaswi Koduru et al.
The majority of the Earth's microbial biomass is found in high pressure environments, raising the question of how protein sequences adapt to such environments. Pressure adaptation is more complex, and less well-understood, than adaptation t...
Multivalency in Tau-Microtubule interactions: Heterogeneous association and functional implications [0.03%]
Tau-微管相互作用中的多价效应：异质缔合与功能影响
Segev Naveh-Tassa,Yaakov Levy
Segev Naveh-Tassa
Tau is a dynamic microtubule-associated protein essential for maintaining microtubule (MT) stability and neuronal function. Its intrinsically disordered nature, combined with its multivalent binding capacity, makes it challenging to charact...
Self-Assembling Nanostructures are Highly Sensitive to Environmental Conditions [0.03%]
自组装纳米结构对环境条件高度敏感
Jordan Aposhian,Surya Pratap S Deopa,Scott Horowitz et al.
Jordan Aposhian et al.
Recent developments in RNA nanotechnology have led to an increase in the design of specific, higher-order RNA structures, which will ultimately be used in drug delivery and immunomodulation applications. As researchers create RNA nanostruct...
IHMValidation: Assessment of Integrative Structure Models Deposited to the Protein Data Bank [0.03%]
PDB中的整合结构模型的IHM验证：评估指标及评分标准
Arthur O Zalevsky,Brinda Vallat,Benjamin M Webb et al.
Arthur O Zalevsky et al.
PDB-IHM is a branch of the Protein Data Bank (PDB), a Worldwide Protein Data Bank (wwPDB) Core Archive, that expands its scope by allowing for additional biomolecular structure representations and types of experimental information (i.e., in...
Evolution and design shape protein dynamics in LOV domains - spanning picoseconds to days [0.03%]
从飞秒到天：蛋白质的动态性质受到LOV结构域中构象变化的限制——进化的结果还是设计的约束？
Raoul E Herzog,Isabelle F Harvey-Seutcheu,Philipp Janke et al.
Raoul E Herzog et al.
Light-sensitive proteins allow organisms to perceive and respond to their environment, and have diversified over billions of years. Among these, Light-Oxygen-Voltage (LOV) domains are widespread photosensors that control diverse physiologic...
Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context [0.03%]
非动机调节残基的序列工程产生了一种有效的单PDZ蛋白质靶向肽，在与疾病相关的细胞环境中具有很高的特异性
Jeanine F Amacher,Patrick R Cushing,Lars Vouilleme et al.
Jeanine F Amacher et al.
PDZ interaction networks are finely-tuned products of evolution. These widespread binding domains recognize short linear motifs (SLiMs), usually at the C-terminus of their interacting partners, and are involved in trafficking and signaling ...