ZART: A Novel Multiresolution Reconstruction Algorithm with Motion-blur Correction for Single Particle Analysis [0.03%]
具有运动模糊校正的单颗粒分析的新型多分辨率重建算法ZART
D Herreros,J Kiska,E Ramírez-Aportela et al.
D Herreros et al.
One of the main purposes of CryoEM Single Particle Analysis is to reconstruct the three-dimensional structure of a macromolecule thanks to the acquisition of many particle images representing different poses of the sample. By estimating the...
Frustration Between Preferred States of Complementary Trinucleotide Repeat DNA Hairpins Anticorrelates with Expansion Disease Propensity [0.03%]
互补三核苷酸重复DNA发夹结构的低能量配对状态之间的能垒与收缩倾向的相关性研究表明两者呈负相关关系
Pengning Xu,Jiahui Zhang,Feng Pan et al.
Pengning Xu et al.
DNA trinucleotide repeat (TRs) expansion beyond a threshold often results in human neurodegenerative diseases. The mechanisms causing expansions remain unknown, although the tendency of TR ssDNA to self-associate into hairpins that slip alo...
Concerted Antibody and Antigen Discovery by Differential Whole-cell Phage Display Selections and Multi-omic Target Deconvolution [0.03%]
基于全细胞噬菌体展示筛选和多组学靶点解析的协同抗体与抗原发现技术
Matthew G Cyr,Henry D Wilson,Anna-Lena Spierling et al.
Matthew G Cyr et al.
Monoclonal antibody (mAb)-based biologics are well established treatments of cancer. Antibody discovery campaigns are typically directed at a single target of interest, which inherently limits the possibility of uncovering novel antibody sp...
Intrinsic Disorder of the Neuronal SNARE Protein SNAP25a in its Pre-fusion Conformation [0.03%]
SNAP25a神经突触蛋白融合前构象的内在无序性
Tobias Stief,Lothar Gremer,Sonja Pribicevic et al.
Tobias Stief et al.
The neuronal SNARE protein SNAP25a (isoform 2) forms part of the SNARE complex eliciting synaptic vesicle fusion during neuronal exocytosis. While the post-fusion cis-SNARE complex has been studied extensively, little is known about the pre...
Computational Methods Toward Unbiased Pattern Mining and Structure Determination in Cryo-Electron Tomography Data [0.03%]
计算 cryo-电子断层扫描数据无偏见模式挖掘和结构测定的方法
Hannah Hyun-Sook Kim,Mostofa Rafid Uddin,Min Xu et al.
Hannah Hyun-Sook Kim et al.
Cryo-electron tomography can uniquely probe the native cellular environment for macromolecular structures. Tomograms feature complex data with densities of diverse, densely crowded macromolecular complexes, low signal-to-noise, and artifact...
Context-dependence of T-loop Mediated Long-range RNA Tertiary Interactions [0.03%]
动态调控长程RNA三级相互作用的T-loop结构依赖于局部环境
Lisa N Hansen,Otto A Kletzien,Marcus Urquijo et al.
Lisa N Hansen et al.
The architecture and folding of complex RNAs is governed by a limited set of highly recurrent structural motifs that form long-range tertiary interactions. One of these motifs is the T-loop, which was first identified in tRNA but is broadly...
CryoRes: Local Resolution Estimation of Cryo-EM Density Maps by Deep Learning [0.03%]
基于深度学习的低温电子显微镜密度图局部分辨率估计(CryoRes)
Muzhi Dai,Zhuoer Dong,Kui Xu et al.
Muzhi Dai et al.
Recent progress in cryo-EM research has ignited a revolution in biological macromolecule structure determination. Resolution is an essential parameter for quality assessment of a cryo-EM density map, and it is known that resolution varies i...
CM2D3: Furnishing the Human Interactome with Structural Models of Protein Complexes Derived by Comparative Modeling and Docking [0.03%]
CM2D3：通过比较建模和对接衍生的蛋白质复合物结构模型充实人类互作组
Patricia Mirela Bota,Altair C Hernandez,Joan Segura et al.
Patricia Mirela Bota et al.
The human interactome is composed of around half a million interactions according to recent estimations and it is only for a small fraction of those that three-dimensional structural information is available. Indeed, the structural coverage...
Joseph Bondy-Denomy,Karen L Maxwell,Alan R Davidson
Joseph Bondy-Denomy
WASCO: A Wasserstein-based Statistical Tool to Compare Conformational Ensembles of Intrinsically Disordered Proteins [0.03%]
基于瓦瑟斯坦的统计工具WASCO比较内在无序蛋白质构象集合的方法
Javier González-Delgado,Amin Sagar,Christophe Zanon et al.
Javier González-Delgado et al.
The structural investigation of intrinsically disordered proteins (IDPs) requires ensemble models describing the diversity of the conformational states of the molecule. Due to their probabilistic nature, there is a need for new paradigms th...