A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases [0.03%]
RAD23A/B与Y型DNA聚合酶之间的新互作机制研究
Nicholas W Ashton,Nancy Jaiswal,Natália Cestari Moreno et al.
Nicholas W Ashton et al.
The Y-family DNA polymerases - Pol ι, Pol η, Pol κ and Rev1 - are most well-known for their roles in the DNA damage tolerance pathway of translesion synthesis (TLS). They function to overcome replication barriers by bypassing DNA damage ...
Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain [0.03%]
皮 Weiner 院士 | 癌症与自闭症：PTEN 突变如何在细胞膜上降解功能和在人脑中的异构体表达
Hyunbum Jang,Jiaye Chen,Lilia M Iakoucheva et al.
Hyunbum Jang et al.
Mutations causing loss of PTEN lipid phosphatase activity can promote cancer, benign tumors (PHTS), and neurodevelopmental disorders (NDDs). Exactly how they preferentially trigger distinct phenotypic outcomes has been puzzling. Here, we de...
Antibody and B-cell Immune Responses Against Bordetella Pertussis Following Infection and Immunization [0.03%]
百日咳感染和免疫后的抗体及B细胞免疫反应
Bahaa Abu-Raya,Mirjam J Esser,Eve Nakabembe et al.
Bahaa Abu-Raya et al.
Neither immunization nor recovery from natural infection provides life-long protection against Bordetella pertussis. Replacement of a whole-cell pertussis (wP) vaccine with an acellular pertussis (aP) vaccine, mutations in B. pertussis stra...
C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies [0.03%]
与血红蛋白病相关的C2H2型锌指转录因子
Xing Zhang,Fangfang Xia,Xiaotian Zhang et al.
Xing Zhang et al.
In humans, specific aberrations in β-globin results in sickle cell disease and β-thalassemia, symptoms of which can be ameliorated by increased expression of fetal globin (HbF). Two recent CRISPR-Cas9 screens, centered on ∼1500 annotated...
Olivia L Mooren,Melissa D Stuchell-Brereton,Patrick McConnell et al.
Olivia L Mooren et al.
Actin capping protein (CP) can be regulated by steric and allosteric mechanisms. The molecular mechanism of the allosteric regulation at a biophysical level includes linkage between the binding sites for three ligands: F-actin, Capping-Prot...
Cristian A Escobar,Riley J Petersen,Marco Tonelli et al.
Cristian A Escobar et al.
Poly(UG) or "pUG" RNAs are UG or GU dinucleotide repeat sequences which are highly abundant in eukaryotes. Post-transcriptional addition of pUGs to RNA 3' ends marks mRNAs as vectors for gene silencing in C. elegans. We previously determine...
Diksha Sharma,Carrie L Partch
Diksha Sharma
Circadian rhythms are genetically encoded molecular clocks for internal biological timekeeping. Organisms from single-cell bacteria to humans use these clocks to adapt to the external environment and synchronize their physiology and behavio...
Coordination of Primer Initiation Within the Catalytic Domain of Human PrimPol [0.03%]
人类PrimPol启动子在催化结构域内的协调作用
Lewis J Bainbridge,Katerina Zabrady,Aidan J Doherty
Lewis J Bainbridge
To facilitate the eukaryotic repriming pathway of DNA damage tolerance, PrimPol synthesises de novo oligonucleotide primers downstream of polymerase-stalling obstacles. These primers enable replicative polymerases to resume synthesis and en...
Determinants of Developability and Evolvability of Synthetic Miniproteins as Ligand Scaffolds [0.03%]
合成最小蛋白作为配体支架的发育性和进化性的决定因素
Adam McConnell,Sun Li Batten,Benjamin J Hackel
Adam McConnell
Binding ligands empower molecular therapeutics and diagnostics. Despite an array of protein scaffolds engineered for binding, the biophysical elements that drive developability and evolvability are not fully understood. In particular, engin...
What Strengthens Protein-Protein Interactions: Analysis and Applications of Residue Correlation Networks [0.03%]
增强蛋白质相互作用的因素——基于残基相关网络的分析及应用
Ta I Hung,Yun-Jung Hsieh,Wei-Lin Lu et al.
Ta I Hung et al.
Identifying residues critical to protein-protein binding and efficient design of stable and specific protein binders are challenging tasks. Extending beyond the direct contacts in a protein-protein binding interface, our study employs compu...