Serum-antibody Profiling of H3N2-infected Ferrets Using a Combinatorial Phage-display Random Peptide Library [0.03%]
利用噬菌体肽池文库对H3N2病毒感染雪貂血清抗体的筛选及鉴定
Tehila Yehudai,Gaik Tamazian,Lakshminarasaiah Uppalapati et al.
Tehila Yehudai et al.
The repertoire of antibodies in serum, known as the "IgOme", is highly diverse and unique to each individual as it reflects the cumulative history of personal encounters with pathogens. Consequently, profiling this repertoire may serve as a...
Gallic acid-induced tetramerisation of the pleiotropic virulence factor SuhB may alter its regulatory role in P. aeruginosa: A structure-based functional study [0.03%]
基于结构的功能研究：杨梅素诱导的多面手毒力因子SuhB四聚化可能改变其在铜绿假单胞菌中的调控作用
Vinay K Yadav,Abinash Jena,Mitali Mukerji et al.
Vinay K Yadav et al.
Nus-factor SuhB protein from Pseudomonas aeruginosa (PaSuhB) is a pleiotropic regulator of multiple genes associated with the virulence of the pathogen. We have solved the crystal structures of PaSuhB in its apo and substrate-bound (D-myo-I...
Mátyás Pajkos,Pierre Barrera,Ilinka Clerc et al.
Mátyás Pajkos et al.
Multi-domain proteins connect functional domains through flexible linkers that critically determine their spatial arrangement and cooperative behavior. Most inter-domain linkers are intrinsically disordered regions (IDRs), whose conformatio...
OpenRecombinHunt: Automatic detection of recombination in publicly available viral sequences [0.03%]
开放重组猎取法：利用公开序列自动检测病毒重组事件
Tommaso Alfonsi,Yavuz Samet Topcuoglu,Matteo Chiara et al.
Tommaso Alfonsi et al.
Zoonotic transmission and viral spillover events pose severe threats to public health, as underscored by recent pandemics. Mitigating these risks requires robust genomic surveillance systems, supported by the growing availability of openly ...
MSIanalyzer: Targeted Nanopore Sequencing Enables Single Nucleotide Resolution Analysis of Microsatellite Instability Diversity [0.03%]
MSIanalyzer：靶向纳米孔测序可实现单核苷酸分辨率的微卫星不稳定性多样性分析
Ting Zhai,Ana Cheong,Daniel J Laverty et al.
Ting Zhai et al.
We present MSIanalyzer, a targeted sequencing-based pipeline profiling microsatellite instability (MSI) at single-nucleotide repeat-unit resolution, with base-level annotation of non-repeat interruptions where identifiable. Using Oxford Nan...
Deeptosis: A Deep Learning-Based Platform for Label-Free Discrimination of Apoptosis and Pyroptosis from Brightfield Microscopy [0.03%]
基于深度学习的无标签白光显微镜凋亡和焦亡鉴别平台 Deeptosis
Haiji Wang,Shaofeng Lin,Chenbei Li et al.
Haiji Wang et al.
Motivation: Accurately distinguishing apoptosis from pyroptosis is essential for studying regulated cell death and its roles in immunity and disease, but their similar morphologies and shared upstream signals make label-f...
Assembly and flexibility of B. burgdorferi periplasmic HtrA hexamers [0.03%]
B. burgdorferi周质HtrA六聚体的装配及灵活性
Anil Kumar Shakya,D Travis Gallager,Vipin Singh Rana et al.
Anil Kumar Shakya et al.
The chaperone/protease HtrA from the Lyme disease pathogen Borrelia burgdorferi (BbHtrA) functions in the maturation of the periplasmic protein BB0323 involved in pathogen infectivity and in the degradation of several other key host and spi...
mdxplain: Scalable molecular dynamics analysis with machine learning-based feature selection and modular workflows [0.03%]
基于机器学习的特征选择和模块化工作流程的可扩展分子动力学分析(MDXPLAIN)
Maximilian Salomon,Maik Pankonin,Maeve Branwen Butler et al.
Maximilian Salomon et al.
Molecular dynamics (MD) simulations provide detailed, time-resolved insight into molecular motion. Advances in hardware and software now make very large systems accessible, increasing the need for efficient tools to analyze the resulting tr...
ShapeME: A tool and web front-end for de novo discovery of structural motifs underpinning protein-DNA interactions [0.03%]
基于蛋白质- DNA相互作用的全新结构基序发现工具及其网络前端界面 ShapeME
Jeremy W Schroeder,Vivian Ramirez,Michael B Wolfe et al.
Jeremy W Schroeder et al.
Determining where proteins bind a genome is paramount to understanding gene regulation. In addition to DNA sequence motifs, structural motifs (e.g., a narrow minor groove width) determine binding for some proteins (1). Algorithms using stru...
The Journey to the Unknown [0.03%]
未知之旅
Li Yu
Li Yu