How Do Amyloid Pathology and Aberrant Neuronal Activity Disrupt Plasticity and Memory in Alzheimer's Disease? [0.03%]
淀粉样蛋白病理和神经元异常活动如何干扰阿尔茨海默病中的可塑性和记忆？
Jaichandar Subramanian
Jaichandar Subramanian
Alzheimer's disease (AD) is increasingly understood as a disorder of network-state and plasticity-capacity, in which amyloid-β and tau pathologies disrupt the activity-dependent mechanisms that build and stabilize memory engrams. Here, I r...
NMDA Receptors in Neuropathic Pain: From Mechanisms to Therapeutic Strategies [0.03%]
神经病理性疼痛中的NMDA受体：从机制到治疗策略
Xi-Yue Li,Zhi-Min Fang,Sheng-Jie Guo et al.
Xi-Yue Li et al.
Neuropathic pain (NP) is a chronic pain condition caused by nerve damage. Current NP treatments have limited efficacy and significant side effects. Emerging evidence demonstrates that N-methyl-d-aspartate receptors (NMDARs) play a key role ...
Carlo Martinotti (1859-1918) of Montiglio d'Asti and His Cortical Interneuron from Historical and Modern Perspectives [0.03%]
卡尔洛·马尔蒂诺蒂（1859-1918）及其来自意大利阿斯蒂蒙迪利奥的发现：从历史和现代观点来看的马尔蒂诺氏细胞
Lazaros C Triarhou
Lazaros C Triarhou
In September 1887, the 28-year-old neuropathologist Carlo Martinotti, an assistant to Camillo Golgi, presented his discovery of a new cell type in the mammalian cerebral cortex at the 12th congress of the Italian Medical Association, held i...
The Role of Exercise in Regulating Brain Health and Aging through Glymphatic Function [0.03%]
运动通过调控脑淋巴系统功能对脑健康和衰老的作用
Junli Wang,Junhua Li
Junli Wang
The glymphatic system is a recently discovered brain clearance pathway that removes metabolic waste, including toxic proteins, via cerebrospinal fluid flow along perivascular spaces. It helps maintain neural homeostasis, and its dysfunction...
Kv4.2 Channels at the Crossroads of Excitability, Plasticity, and Synaptic Signaling [0.03%]
Kv4.2通道在兴奋性、可塑性和突触信号传导的交汇处
Michael Andreyanov,Ido Carmi,Shai Berlin
Michael Andreyanov
Kv4.2 channels, principal mediators of the neuronal A-type K+ current, are emerging as multifunctional regulators of excitability, plasticity, and synaptic signaling. Beyond their canonical role in shaping backpropagating action potentials,...
Echoes of Pink Noise: A Hypothesized Mechanism for Enhancing Sleep-Dependent Memory Consolidation with Auditory Stimulation [0.03%]
粉噪音的回响：关于通过声音刺激来增强睡眠依赖型记忆巩固的假设机制
Saied Sabaghypour,Farhad Farkhondeh Tale Navi,Laura J Batterink
Saied Sabaghypour
Emerging evidence highlights the potential role of auditory stimulation in enhancing sleep-dependent memory consolidation. Pink noise appears to be an effective auditory stimulus for enhancing memory consolidation, likely due to its wide-ra...
Kallol Bera,Loren L Looger,Alex Proekt et al.
Kallol Bera et al.
Ketamine is a unique anesthetic agent that induces dissociative anesthesia, characterized by perceptual detachment, analgesia, and altered states of consciousness. Beyond its widespread use in anesthesia, subhypnotic ketamine dosing has eme...
Holly Rayson,Quentin Moreau,Solene Gailhard et al.
Holly Rayson et al.
Neural activity in the beta band is increasingly recognized to occur not as sustained oscillations but as transient burst-like events. These beta bursts are diverse in shape, timing, and spatial distribution, but their precise functional si...