Nico Lehmann
Nico Lehmann
Learning shapes the human brain, yet structural changes underlying this process remain difficult to characterize in vivo. Recent advances in magnetic resonance imaging (MRI)-including relaxometry, magnetization transfer, proton density, and...
The Unexplored Role of Noncoding Regulatory RNAs in Engram Dynamics [0.03%]
非编码调节RNA在记忆痕迹动力学中的作用不容忽视
Prakruti Nanda,Gerhard Schratt
Prakruti Nanda
Memory is stored in distributed neuronal ensembles known as engrams, which are defined by their activation during encoding and their necessity for recall. Current research relies heavily on immediate-early gene (IEG) expression to map these...
Bhanu P Tewari,Lata Chaunsali,Harald Sontheimer
Bhanu P Tewari
Perineuronal nets (PNNs) are morphologically distinct aggregates of extracellular matrix that predominantly ensheath fast-spiking GABAergic neurons in the brain. Discovered in the late 19th century by Camilo Golgi, PNNs have emerged as an i...
How Do Amyloid Pathology and Aberrant Neuronal Activity Disrupt Plasticity and Memory in Alzheimer's Disease? [0.03%]
淀粉样蛋白病理和神经元异常活动如何干扰阿尔茨海默病中的可塑性和记忆？
Jaichandar Subramanian
Jaichandar Subramanian
Alzheimer's disease (AD) is increasingly understood as a disorder of network-state and plasticity-capacity, in which amyloid-β and tau pathologies disrupt the activity-dependent mechanisms that build and stabilize memory engrams. Here, I r...
NMDA Receptors in Neuropathic Pain: From Mechanisms to Therapeutic Strategies [0.03%]
神经病理性疼痛中的NMDA受体：从机制到治疗策略
Xi-Yue Li,Zhi-Min Fang,Sheng-Jie Guo et al.
Xi-Yue Li et al.
Neuropathic pain (NP) is a chronic pain condition caused by nerve damage. Current NP treatments have limited efficacy and significant side effects. Emerging evidence demonstrates that N-methyl-d-aspartate receptors (NMDARs) play a key role ...