SNAREopathy in Neurologic Disorders: From Synaptic Mechanisms to Genetic and Epigenetic Regulation [0.03%]
神经疾病中的SNARE病：从突触机制到遗传和表观遗传调控
Valentinus Besin,Lisa Thalia Mulyanata,Farizky Martriano Humardani
Valentinus Besin
Synaptic dysfunction is a central feature of many neurologic diseases, and the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex plays a critical role in regulating synaptic vesicle fusion and neurotransm...
Nonclustered Protocadherins in Autism: Integrating Cell Adhesion and Activity-Dependent Signalling [0.03%]
自闭症中的非聚簇原钙粘蛋白：整合细胞黏附与活动依赖性信号转导
Federico Miozzo
Federico Miozzo
Autism spectrum disorders (ASD) are heterogeneous neurodevelopmental conditions characterized by deficits in social communication and repetitive behaviours, collectively affecting nearly 2% of the global population. ASD is strongly heritabl...
Brain-on-a-Chip and Blood-Brain Barrier-on-a-Chip Modeling for Neurodegenerative Disorders: Recent Progress [0.03%]
脑芯片和血脑屏障芯片在神经退行性疾病中的建模：最近的进展
Duraisamy Kempuraj,Huachen Shi,Travis D Truong et al.
Duraisamy Kempuraj et al.
Brain-on-a-chip is a microphysiologic platform that comprises cultured brain cells to understand brain disease pathogenesis and treatment. The blood-brain barrier (BBB) of the neurovascular unit serves as a highly selective molecular transp...
Kimihiro Nakamura
Kimihiro Nakamura
The left ventral premotor cortex (PMv) has not been fully acknowledged as a key component of the brain's network for reading. This region, corresponding to Brodmann area (BA) 6, is cytoarchitecturally distinct from adjacent Broca's area (BA...
Airi Watanabe,Connie Guo,P Jesper Sjöström
Airi Watanabe
Learning and memory were long thought to be the domains of neurons and neural networks, but recent work across brain systems has established that astrocytes play a role in synaptic plasticity and information storage. However, it remains unc...
Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction [0.03%]
突触旁星形胶质细胞进程作为通讯中心和功能障碍的早期位点
Francesca Puletti,Isabella Tugulu,Soyon Hong
Francesca Puletti
Astrocytes play key roles in shaping the synaptic environment, yet the cellular structures through which they interact with individual synapses remain incompletely understood. Perisynaptic astrocytic processes (PAPs) are ultrathin astrocyti...
Heat Shock Proteins in Schizophrenia: Integrating Stress Responses, Molecular Pathways, and Emerging Therapeutic Strategies [0.03%]
热休克蛋白与精神分裂症：整合压力反应、分子通路和新兴治疗策略
Mohammad Navid Ebrahimi,Mohammad Banazadeh,Kristi Anne Kohlmeier et al.
Mohammad Navid Ebrahimi et al.
Schizophrenia is a severe mental disorder characterized by a range of symptoms and significant disability, with disrupted proteostasis identified as a critical pathophysiological factor. This comprehensive review evaluates the involvement o...
The Neurochemical Orchestra of the Runner's High: A Narrative Review of Neuromodulatory Mechanisms with a Focus on Endocannabinoids [0.03%]
跑者高潮的神经化学管弦乐：以内源大麻素为重点的神经调节机制叙述性综述
Michael Siebers,Deborah Canales-Romero,Johannes Fuss
Michael Siebers
Endurance exercise can induce a transient euphoric state known as the runner's high, characterized by euphoria, anxiolysis, hypoalgesia, and a subjective sense of flow. Traditionally, this phenomenon has been interpreted within an "either-o...