Jithin Thomas,David P Goldberg
Jithin Thomas
A high-valent iron(IV)-oxo porphyrin radical cation (FeIV(O)(porph+•) serves as a key, reactive intermediate for a range of heme enzymes, including cytochrome P450 (CYP), horseradish peroxidase (HRP), and catalase (CAT). Synthetic analogs ...
Interactions of metronidazole and chloramphenicol with myoglobin: Crystal structure of a Mb-acetamide product [0.03%]
甲硝唑和氯霉素与肌红蛋白的相互作用：Mb-醋酰胺产物的晶体结构
Samantha M Powell,Kiana Y Prather,Nancy Nguyen et al.
Samantha M Powell et al.
Nitroorganics present a general concern for a safe environment due to their health hazards. However, some nitroorganics such as metronidazole (Mtz) and chloramphenicol (CAM) also possess medicinal value. Mtz and CAM can undergo reductive bi...
Photodynamic therapy, priming and optical imaging: Potential co-conspirators in treatment design and optimization - a Thomas Dougherty Award for Excellence in PDT paper [0.03%]
光动力疗法、预处理和光学影像在治疗设计与优化中的潜力——托马斯·多赫蒂奖优秀论文
Pushpamali De Silva,Mohammad A Saad,Hanna C Thomsen et al.
Pushpamali De Silva et al.
Photodynamic therapy is a photochemistry-based approach, approved for the treatment of several malignant and non-malignant pathologies. It relies on the use of a non-toxic, light activatable chemical, photosensitizer, which preferentially a...
The Selective Monobromination of a Highly Sterically Encumbered Corrole: Structural and Spectroscopic Properties of Fe(Cl)(2-Bromo-5,10,15-tris(triphenyl)phenyl corrole) [0.03%]
高空间位阻三苯基苯基钴啉的选择性单溴化及Fe(Cl)(2-溴-5,10,15-三(三苯基)-苯基钴啉)的结构和光谱性质研究
Jessica G Alvarado,Daniel C Cummins,Andrada Diaconescu et al.
Jessica G Alvarado et al.
The corrole ligand serves as a versatile tri-anionic, macrocyclic platform on which to model biological catalytic systems, as well as to effect mechanistically challenging chemical transformations. Here in we describe the synthesis, structu...
N-methyl mesoporphyrin IX as a highly selective light-up probe for G-quadruplex DNA [0.03%]
N-甲基中孔金属卟啉IX作为一种高选择性的G-四链体DNA探针
Ariana Yett,Linda Yingqi Lin,Dana Beseiso et al.
Ariana Yett et al.
N-methyl mesoporphyrin IX (NMM) is a water-soluble, non-symmetric porphyrin with excellent optical properties and unparalleled selectivity for G-quadruplex (GQ) DNA. G-quadruplexes are non-canonical DNA structures formed by guanine-rich seq...
Vascular targeted photodynamic therapy: A review of the efforts towards molecular targeting of tumor vasculature [0.03%]
血管靶向光动力治疗：分子靶向作用于肿瘤血管的研究进展综述
Vida Mashayekhi,Charlotte Op &#x;t Hoog,Sabrina Oliveira
Vida Mashayekhi
The therapeutic value of vascular targeted photodynamic therapy (VTP) for cancer has already been recognized in the clinic: TOOKAD® has been clinically approved in Europe and Israel for treatment of men with low-risk prostate cancer. When ...
Elizabeth A Okoth,Zehua Zhou,Benson Ongarora et al.
Elizabeth A Okoth et al.
An isothiocyanato-functionalized phthalocyanine (Pc) was synthesized in good yield from the corresponding amine-substituted Pc. This Pc reacted with ethanolamine, biotin hydrazine, and biotin diethylamine under mild conditions (room tempera...
Syntheses and PDT activity of new mono- and di-conjugated derivatives of chlorin e6 [0.03%]
新的单式和双式氯霉素e6衍生物的合成及PDT活性研究
Hui Chen,Stewart W Humble,R G Waruna Jinadasa et al.
Hui Chen et al.
Syntheses of three new chlorin e6 conjugates for PDT of tumors are reported. One of the new compounds 17 is conjugated with lysine at the 131-position, but the others are mono-conjugated 14 or diconjugated 15 with the non-amino acid species...
Targeting of the epidermal growth factor receptor with mesoporphyrin IX-peptide conjugates [0.03%]
含有肽的中孔卟啉IX结合物与表皮生长因子受体的靶向作用研究
Krystal R Fontenot,Benson G Ongarora,Logan E LeBlanc et al.
Krystal R Fontenot et al.
The synthesis and in vitro evaluation of four mesoporphyrin IX-peptide conjugates designed to target EGFR, over-expressed in colorectal and other cancers, are reported. Two peptides with known affinity for EGFR, LARLLT (1) and GYHWYGYTPQNVI...
Characterization of the mixed axial ligand complex (4-cyanopyridine)(imidazole)(tetramesitylporphinato)iron(iii) perchlorate. Stabilization by synergic bonding [0.03%]
（4-氰基吡啶）（咪唑）（四甲苯基卟啉酸）铁（III）高氯酸混合轴配体配合物的表征。协同络合稳定化作用
Judith A Serth-Guzzo,Ilona Turowska-Tyrk,Martin K Safo et al.
Judith A Serth-Guzzo et al.
The reaction of [Fe(TMP)(OClO3)], where TMP is the dianion of tetramesitylporphyrin, with a combination of a strong π-acceptor ligand and a π-donating imidazole can lead to the preparation of mixed-ligand complexes [Fe(Porph)(4-CNPy)(L)]+...