Nonideal behavior of void volume markers in polar-organic chiral HPLC on polysaccharide-based chiral stationary phases [0.03%]
基于多糖手性固定相的有机介质中的手性HPLC中空穴体积标记物的非理想行为
Arcadius V Krivoshein,Zhaochang Hu
Arcadius V Krivoshein
Polysaccharide-based chiral stationary phases account for a majority of chiral HPLC separations. Their behavior in normal-phase and reversed-phase modes of separation has been studied extensively. However, much less is known about their beh...
Analysis of gentisic acid and related renal cell carcinoma biomarkers using reversed-phase liquid chromatography with water-rich mobile phases [0.03%]
使用富水流动相的反相液相色谱分析邻香草酸及相关的肾细胞癌生物标志物
Kaushalya Sharma Dahal,Sanjeewa Gamagedara,Undugodage Don Nuwan Perera et al.
Kaushalya Sharma Dahal et al.
The problem of longer retention times using water-rich mobile phases in reversed phase liquid chromatography (RPLC) has been addressed using hydrophobic alcohols such as butanol in very low quantities (approximately 0.1%) as the organic mod...
Determination of the Transplacental Transfer of Paclitaxel and Antipyrine by High Performance Liquid Chromatography Coupled with Photodiode Array Detector [0.03%]
高效液相色谱-光电二极管阵列检测法测定紫杉醇和安替比林的胎盘转运率
Shariq Ali,Norah Albekairi,Xiao-Ming Wang et al.
Shariq Ali et al.
Ex vivo placental perfusion experiments are important in understanding the quantity and mechanisms of xenobiotic transport to the fetus during pregnancy. Our study demonstrates that paclitaxel and antipyrine concentrations in placental perf...
Determination of the enantiomeric purity of epinephrine by HPLC with circular dichroism detection [0.03%]
高效液相色谱-圆二色检测手性测定肾上腺素的旋光纯度
Douglas Kirkpatrick,Jingyue Yang,Michael Trehy
Douglas Kirkpatrick
Several hundred drug substances approved by the U.S. Food and Drug Administration are chiral molecules. For the enantiomeric purity assessment, current practice is to develop separation techniques using chiral columns or mobile phase modifi...
Determination of Methotrexate, 7-Hydroxymethotrexate, and 2,4-Diamino-N10-methylpteroic Acid by LC-MS/MS in Plasma and Cerebrospinal Fluid and Application in a Pharmacokinetic Analysis of High-Dose Methotrexate [0.03%]
甲氨蝶呤、7-羟基甲氨蝶呤和2，4-二氨基-N10-甲基喋啶酸的LC-MS/MS法检测及其在大剂量甲氨蝶呤药代动力学研究中的应用
Michael S Roberts,Nicholas S Selvo,Jessica K Roberts et al.
Michael S Roberts et al.
A rapid and robust method for measuring methotrexate (MTX) and its two primary metabolites, 7-hydroxymethotrexate (7-OHMTX) and 2,4-diamino-N10-methylpteroic acid (DAMPA), was developed for use in pharmacokinetic studies of plasma and cereb...
Simultaneous quantitative analysis of main components in linderae reflexae radix with one single marker [0.03%]
连钱草中主要化学成分的一标志物同步质量浓度分析方法学研究
Li-Li Wang,Yun-Bin Zhang,Xiao-Ya Sun et al.
Li-Li Wang et al.
Establish a quantitative analysis of multi-components by the single marker (QAMS) method for quality evaluation and validate its feasibilities by the simultaneous quantitative assay of four main components in Linderae Reflexae Radix. Four m...
SEPARATION AND PURIFICATION OF TWO MINOR COMPOUNDS FROM RADIX ISATIDIS BY INTEGRATIVE MPLC AND HSCCC WITH PREPARATIVE HPLC [0.03%]
结合制备型高效液相色谱和综合模式液相色谱及高速 counter-current 沉降色谱分离板蓝根中两极性差异大且含量低的化合物
Zhenjie Liang,Bin Li,Yong Liang et al.
Zhenjie Liang et al.
Radix isatidis has been widely used as a Chinese traditional medicine for its anti-virus and anticancer activities where the minor components may contribute to these beneficial pharmaceutical effects. In order to enrich the target minor com...
PREPARATION AND EVALUATION OF HPLC CHIRAL STATIONARY PHASES BASED ON CATIONIC/BASIC DERIVATIVES OF CYCLOFRUCTAN 6 [0.03%]
基于阳离子/碱性环糊精衍生物的手性固定相的制备及评价
Nilusha L Padivitage,Jonathan P Smuts,Zachary S Breitbach et al.
Nilusha L Padivitage et al.
The cyclofructan 6 (CF6) macrocyclic-oligosaccharide was derivatized with five different substituents able to bear positive charges: propyl imidazole (IM) methyl benzimidazole (BIM), dimethyl aminopropyl (AP), pyridine (PY) and dimethyl ami...
Isolation of Sutherlandioside B from Sutherlandia frutescens by Spiral Countercurrent Chromatography [0.03%]
螺旋式.counter.current.色谱法分离苏伦戴尔亚属植物中.sutherlandioside.b成分
Korey J Brownstein,George E Rottinghaus,Martha Knight et al.
Korey J Brownstein et al.
The introduction of spiral countercurrent chromatography in the last few years using new separation columns such as the spiral tubing support rotor has enabled the application of more polar volatile solvent systems for natural products sepa...
Fengkang Wang,Yoichiro Ito,Yun Wei
Fengkang Wang
As countercurrent chromatography is becoming an established method in chromatography for many kinds of products, it is becoming increasingly important to model the process and to be able to predict the peaks for a given process. The CCC ind...