Two-photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement [0.03%]
双光子荧光各向异性显微镜用于成像及直接测量细胞内药物靶点结合情况
Claudio Vinegoni,John M Dubach,Paolo Fumene Feruglio et al.
Claudio Vinegoni et al.
Small molecule therapeutic drugs must reach their intended cellular targets (pharmacokinetics) and engage them to modulate therapeutic effects (pharmacodynamics). These processes are often difficult to measure in vivo due to their complexit...
Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography [0.03%]
磁性和等离子体对比剂在光学 coherence 计算机断层扫描中的应用
Amy L Oldenburg,Richard L Blackmon,Justin M Sierchio
Amy L Oldenburg
Optical coherence tomography (OCT) has gained widespread application for many biomedical applications, yet the traditional array of contrast agents used in incoherent imaging modalities do not provide contrast in OCT. Owing to the high bioc...
Jeffrey J Field,Kraig E Sheetz,Eric V Chandler et al.
Jeffrey J Field et al.
Multifocal multiphoton microscopy (MMM) in the biological and medical sciences has become an important tool for obtaining high resolution images at video rates. While current implementations of MMM achieve very high frame rates, they are li...
Acoustic Radiation Force Optical Coherence Elastography of Corneal Tissue [0.03%]
基于声辐射力的角膜组织光学相干弹性成像研究
Yueqiao Qu,Teng Ma,Youmin He et al.
Yueqiao Qu et al.
We report on a real-time acoustic radiation force optical coherence elastography (ARF-OCE) system to map the relative elasticity of corneal tissue. A modulated ARF is used as excitation to vibrate the cornea while OCE serves as detection of...
Selective photonic disinfection of cell culture using a visible ultrashort pulsed laser [0.03%]
利用可见超短脉冲激光选择性地对细胞培养进行光子消毒
Shaw-Wei D Tsen,Karen Kibler,Bert Jacobs et al.
Shaw-Wei D Tsen et al.
Microbial contamination of cell culture is a major problem encountered both in academic labs and in the biotechnology/pharmaceutical industries. A broad spectrum of microbes including mycoplasma, bacteria, fungi, and viruses are the causati...
The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities [0.03%]
激光斑点成像在葡萄酒色斑研究中的作用： recent advances and opportunities近期进展与机遇
Bernard Choi,Wenbin Tan,Wangcun Jia et al.
Bernard Choi et al.
Here, we review our current knowledge on the etiology and treatment of port-wine stain (PWS) birthmarks. Current treatment options have significant limitations in terms of efficacy. With the combination of 1) a suitable preclinical microvas...
Longitudinal Imaging of Heart Development With Optical Coherence Tomography [0.03%]
光学 coherence 段用于心脏发育的纵向 imaging
Michael W Jenkins,Michiko Watanabe,Andrew M Rollins
Michael W Jenkins
Optical coherence tomography (OCT) has great potential for deciphering the role of mechanics in normal and abnormal heart development. OCT images tissue microstructure and blood flow deep into the tissue (1-2mm) at high spatiotemporal resol...
Development of Ultrasound-switchable Fluorescence Imaging Contrast Agents based on Thermosensitive Polymers and Nanoparticles [0.03%]
基于温敏聚合物及纳米粒子的超声可切换荧光成像对比剂的研制
Bingbing Cheng,Ming-Yuan Wei,Yuan Liu et al.
Bingbing Cheng et al.
In this work we first introduced a recently developed high-resolution, deep-tissue imaging technique, ultrasound-switchable fluorescence (USF). The imaging principles based on two types of USF contrast agents were reviewed. To improve USF i...
Polarization Effects in Optical Coherence Tomography of Various Biological Tissues [0.03%]
不同生物组织光学相干层析成像的偏振效应
Johannes F de Boer,Shyam M Srinivas,B Hyle Park et al.
Johannes F de Boer et al.
Polarization sensitive optical coherence tomography (PS-OCT) was used to obtain spatially resolved ex vivo images of polarization changes in skeletal muscle, bone, skin and brain. Through coherent detection of two orthogonal polarization st...
Multimodal In Vivo Skin Imaging with Integrated Optical Coherence and Multiphoton Microscopy [0.03%]
集成光学 coherence 和多光子显微镜的多模在 vivo 皮肤成像
Benedikt W Graf,Stephen A Boppart
Benedikt W Graf
In this paper, we demonstrate high-resolution, multimodal in vivo imaging of human skin using optical coherence (OCM) and multiphoton microscopy (MPM). These two modalities are integrated into a single instrument to enable simultaneous acqu...