Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties [0.03%]
作为抗糖尿病药物的噻唑啶酮-三氮唑衍生物的机械化学合成：药代动力学，分子对接及体外抗糖尿病性质研究
M B Taj,A Raheel,W Alelwani et al.
M B Taj et al.
Mechanochemistry is an eco-friendly and solventless method. In the present study, the surface of a custom-made closed mortar and pestle is used as a catalyst to synthesize thiazolidinone-triazole derivatives successfully. The compounds were...
S V Pechinskii,A G Kuregyan,E T Oganesyan
S V Pechinskii
A regioselective method for the synthesis of esters of quercetin and myricetin at the hydroxy group in the position 3 was developed. As acids participating in the esterification reaction, 2-hydroxybenzoic (salicylic), 4-hydroxybenzoic, 2,6-...
Synthesis of N-[1-(2-Acetyl-4,5-dimethoxyphenyl)propan-2-yl]benzamide and Its Copper(II) Complex [0.03%]
N-[1-(2-乙酰-4,5-二甲氧基苯基)丙-2-基]苯胺及其铜(II)配合物的合成
P Marinova,S Nikolova,S Tsoneva
P Marinova
This paper represents a convenient method for the synthesis of N-[1-(2-acetyl-4,5-dimethoxyphenyl)propan-2-yl]benzamide and its Cu(II) complex. In silico analysis predicted spasmolytic activity for the compound. Based on the in silico calcu...
N A Ivantsova,P R Karataeva
N A Ivantsova
The catalytic properties of iron ions in the oxidative destruction of the active pharmaceutical ingredient paracetamol, in the presence of hydrogen peroxide have been investigated. It was found that in the presence of a homogeneous catalyst...
Optimization of the Technique for Obtaining Selenium Nanoparticles Stabilized with Cocamidopropyl Betaine [0.03%]
月桂基甜菜碱稳定硒纳米颗粒制备工艺优化
A V Blinov,D G Maglakelidze,E A Brazhko et al.
A V Blinov et al.
With the aim of optimizing the technique for the synthesis of selenium nanoparticles stabilized with cocamidopropyl betaine, a multifactorial experiment with three input parameters and three levels of variation was carried out. The selenous...
Effect of a Substituent in the Fourth Position on the Optical Properties of 2-Oxonicotinonitriles [0.03%]
第四位取代基对2-氧代烟腈光学性质的影响
S P Sorokin,S V Fedoseev,O V Ershov
S P Sorokin
Based on six representatives of 2-oxonicotinonitriles, the effect of the nature of the substituent in the fourth position of the pyridine system on the photophysical characteristics was studied. The role of the donor/acceptor nature of the ...
Synthesis and Anticancer Evaluation of New Thiazole and Thiadiazole Derivatives Bearing Acetanilide Moiety [0.03%]
带有乙酰胺基的新噻唑和噻二唑衍生物的合成及其抗肿瘤活性评价
Ali El-Rayyes,Ahbarah M Soliman,Ali Saeed
Ali El-Rayyes
New thiazole and thiadiazole derivatives bound to the acetanilide moiety were synthesized and evaluated for their cytotoxic activity. The precursor N-(4-acetamidophenyl)-N'-phenylthiourea (2) was cyclocondensed with ethyl bromoacetate to af...
Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents [0.03%]
新4-喹诺酮类抗微生物剂的设计、合成、构效关系及药代动力学预测
G G Dubal,P R Vachchharajani,M J Solanki et al.
G G Dubal et al.
s of new 4-quinolone derivatives was synthesized by conventional heating method. For the synthesized compounds, we performed pharmacokinetic prediction, SAR and antimicrobial assay. The presence of halogen elements plays a key role in the b...
Interaction of 5-[4'-(N-Methyl-1,3-benzimidazol-2-yl)phenyl]-10,15,20-tri-(N-methyl-3'-pyridyl)porphyrin Triiodide with SARS-CoV-2 Spike Protein [0.03%]
5-[4'-(N-甲基-1,3-苯并咪唑-2-基)苯基]-10,15,20-三(N-甲基-3'-吡啶基)卟啉三碘化物与SARS-CoV-2刺突蛋白的相互作用
S A Syrbu,A N Kiselev,M A Lebedev et al.
S A Syrbu et al.
The results of experimental studies of the interaction of the S-protein with a monohetaryl-substituted porphyrin containing a benzimidazole residue are presented. It has been revealed that the S-protein forms high-affinity complexes with th...
Cyclization Reaction of 3,5-Diacetyl-2,6-dimethylpyridine with Salicylic Aldehyde and Its Derivatives: Quantum-Chemical Study and Molecular Docking [0.03%]
3,5-二乙酰-2,6-二甲基吡啶与水杨醛及其衍生物的环化反应：量子化学研究和分子对接
A L Stalinskaya,S Y Chikunov,I A Pustolaikina et al.
A L Stalinskaya et al.
Computational study of some details of the cyclization reaction between 3,5-diacetyl-2,6-dimethylpyridine and salicylic aldehyde in an acidic medium was performed by the DFT RB3LYP/6-31G method using the Gaussian-2016 software package. It w...