A Mini Review on Discovery and Synthesis of Remdesivir as an Effective and Promising Drug against COVID-19 [0.03%]
有关瑞德西韦作为有效有前景的抗COVID-19药物的研发和合成的小综述
E Zarenezhad,S Behrouz,M Farjam et al.
E Zarenezhad et al.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as a new human coronavirus has begun spreading over Wuhan City/China in December 2019, and then spread rapidly worldwide, causing pneumonia called COVID-19. Up to now, the sci...
Modified Oligonucleotides: New Structures, New Properties, and New Spheres of Application [0.03%]
新型寡核苷酸及其应用
V G Metelev,T S Oretskaya
V G Metelev
Nucleic acids have made a long and arduous journey "from the bench to the bedside." At present, it can be assumed that drugs based on modified oligonucleotides will find a worthy application in personalized medicine of the future. ...
Synthesis, Molecular Docking, In Silico ADME Predictions, and Toxicity Studies of N-Substituted-5-(4-Chloroquinolin-2-yl)-1,3,4-Thiadiazol-2-Amine Derivatives as COVID-19 Inhibitors [0.03%]
N取代的5-(4氯喹啉-2-基)-1,3,4噻二唑-2-胺衍生物作为COVID-19抑制剂的合成、分子对接、ADME预测及毒性研究
Hanaa S Mohamed,Walaa S El-Serwy,Weam S El-Serwy
Hanaa S Mohamed
The present study aimed to synthesis N-substituted-5-(4-chloroquinolin-2-yl)-1,3,4-thiadiazol-2-amine derivatives. Molecular docking study of the synthesized compounds was carried out. COVID-19 docked with the synthesized compounds and the ...
Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases [0.03%]
用于预防b型流感嗜血杆菌疾病的糖缀合疫苗
E A Khatuntseva,N E Nifantiev
E A Khatuntseva
This review summarizes the experience in laboratory- and industrial-scale syntheses of glycoconjugate vaccines used for prevention of infectious diseases caused by Haemophilus influenzae type b bacteria based on the linear capsular polysacc...
Synthetic Analogs of Streptococcus pneumoniae Capsular Polysaccharides and Immunogenic Activities of Glycoconjugates [0.03%]
人造肺炎链球菌荚膜多糖及其糖缀合物的免疫活性
M L Gening,E A Kurbatova,N E Nifantiev
M L Gening
Streptococcus pneumoniae is a Gram-positive bacterium (pneumococcus) that causes severe diseases in adults and children. It was established that some capsular polysaccharides of the clinically significant serotypes of S. pneumoniae in the c...
Monoclonal Antibody HlyIIC‑15 to C-End Domain HlyII B. cereus Interacts with the Trombin Recognition Site [0.03%]
单克隆抗体HlyIIC‑15与B. cereusC‐末端结构域HlyII在凝血酶识别位点发生相互作用
A V Zamyatina,N V Rudenko,A P Karatovskaya et al.
A V Zamyatina et al.
Among the panel of monoclonal antibodies to the recombinant protein HlyIICTD Bacillus cereus an antibody was found capable of forming an immune complex with a thrombin recognition region, the amino acid sequence of which is located inside t...
A A Baranova,V A Alferova,V A Korshun et al.
A A Baranova et al.
Extremophilic microorganisms, which are capable of functioning normally at extremely high or low temperatures, pressure, and in other environmental conditions, have been in the focus of microbiologists' attention for several decades due to ...
Multiplex PCR for Identification of Bacterial Pathogens of Infectious Pneumonia [0.03%]
多重PCR技术在肺炎病原菌鉴定中的应用
S A Lapa,E S Klochikhina,R A Miftakhov et al.
S A Lapa et al.
A multiplex PCR system has been developed and optimized for rapid detection of the five main pathogens of bacterial pneumonia. The system can be expanded to analyze viral pathogens of pneumonia (DNA- and RNA-containing viruses), as well as ...
5-(Perylen-3-ylethynyl)uracil Derivatives Inhibit Reproduction of Respiratory Viruses [0.03%]
5-(perylen-3-基乙炔基)-尿嘧啶衍生物抑制呼吸道病毒的繁殖
Y V Nikolayeva,E A Ulashchik,E V Chekerda et al.
Y V Nikolayeva et al.
In this work, we describe the synthesis of 5-(perylen-3-ylethynyl)uridine and its ability to effectively inhibit the replication of respiratory disease pathogens in cell culture, namely: influenza A virus (IVA); type 3 parainfluenza virus (...
Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters [0.03%]
甘草酸与D-氨基酸酯类衍生物的合成及其抗病毒活性研究
A I Fayrushina,L A Baltina Jr,L A Baltina et al.
A I Fayrushina et al.
Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of N-hydroxybenzotriazole or N-hydroxysuccinimide with N...