Effective Drug Candidates against Global Pandemic of Novel Corona Virus (nCoV-2019): A Probability Check through Computational Approach for Public Health Emergency [0.03%]
计算出全球新型冠状病毒（nCoV-2019）的有效药物候选者：通过计算方法进行概率检验以应对公共卫生紧急情况
C G Bonde,J Gawad,R P Bhole et al.
C G Bonde et al.
The infection of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started form Wuhan, Chinais a devastating and the incidence rate has increased worldwide. Due to the lack of effective treatment against SARS-CoV-2, various str...
V R Litvinova,A P Rudometov,L I Karpenko et al.
V R Litvinova et al.
Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which have several very useful advantages over other types of vaccines. Since mRNA encodes only the target a...
A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix [0.03%]
一种合成可电离脂质ALC-0315的路线，它是mRNA疫苗脂质组分的关键成分
I A Boldyrev,V P Shendrikov,A G Vostrova et al.
I A Boldyrev et al.
The ionizable lipid ALC-0315, ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), is a component of the lipid matrix of the prophylactic SARS-CoV-2 mRNA vaccine produced by Pfizer/BioNTech. This lipid ensures efficient vac...
The Synthesis and Transfection Activity of Disulfide Polycationic Amphiphiles [0.03%]
含二硫键的多阳离子两亲剂的合成及其转染活性研究
I A Petukhov,P A Puchkov,N G Morozova et al.
I A Petukhov et al.
Some new polycationic amphiphiles containing a disulfide group were synthesized. Cationic liposomes formed from the compounds synthesized and a helper lipid 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine were not toxic for HEK293 and He...
V S Kulkarni,V Alagarsamy,V R Solomon et al.
V S Kulkarni et al.
Drug repurposing is using an existing drug for a new treatment that was not indicated before. It has received immense attention during the COVID-19 pandemic emergency. Drug repurposing has become the need of time to fasten the drug discover...
Quaternary Ammonium Salt Strategy and Molecular Docking Studies of Novel 5-Acyl-8-(Arylamino)-Quinolines by Acetyl and Methanesulfonyl Chloride for Dual Evaluation Bioactivity [0.03%]
新型5-酰基-8-(芳氨基)喹啉类衍生物的乙酰氯和甲磺酰氯季铵盐策略及分子对接研究与活性评估
Feng Jin,Xueyong Qi
Feng Jin
Six quinoline derivatives containing quaternary ammonium salts and acyl chloride groups were synthesized from ethyl 8-chloro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate in several step. With berberine as the positive control, three human can...
F V Shirshikov,J A Bespyatykh
F V Shirshikov
Increasing the accuracy of pathogen identification and reducing the duration of analysis remain relevant for modern molecular diagnostics up to this day. In laboratory and clinical practice, detection of pathogens mostly relies on methods o...
Erratum to: Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome [0.03%]
《海洋硫酸富果糖多糖在COVID-19及后COVID-19综合征治疗和预防中的应用前景》的勘误
M V Kiselevskiy,N Yu Anisimova,M I Bilan et al.
M V Kiselevskiy et al.
[This corrects the article DOI: 10.1134/S1068162022060152.]. © The Author(s) 2022, ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2022, Vol. 4...
Published Erratum
Russian journal of bioorganic chemistry. 2022;48(6):1372. DOI:10.1134/S1068162022340015 2022
Design, Synthesis, Anti-Tubercular Evaluation and Teratogenicity Studies of Furanyl Pyrazolo[3,4- b] Quinoline-5-Ones [0.03%]
呋喃基吡唑并 [3,4-b] 吲哚-5-酮的设计、合成、抗结核评价和致畸性研究
N R Babu,R S Raju,R R Alavala et al.
N R Babu et al.
We have synthesized novel pyrazolo-quinoline analogues (P1-10) in an effort to create newer antitubercular drugs against the rising bacterial resistance. NMR, IR and ESI-MS spectra were utilized to characterize the synthesised compounds. Th...
Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome [0.03%]
海洋硫酸化富岩藻糖多糖用于治疗和预防新型冠状病毒肺炎及后遗症的前景分析
M V Kiselevskiy,N Yu Anisimova,M I Bilan et al.
M V Kiselevskiy et al.
Symptoms of the new coronavirus infection that appeared in 2019 (COVID-19) range from low fever and fatigue to acute pneumonia and multiple organ failure. The clinical picture of COVID-19 is heterogeneous and involves most physiological sys...