The Influence of Lipid Matrix Composition on the Microenvironment of Levofloxacin in Liposomal Forms [0.03%]
脂质体制剂中脂质基质组成对左氧氟沙星微环境的影响
I M Le-Deygen,A S Safronova,I M Kolmogorov et al.
I M Le-Deygen et al.
We have studied the interaction of the antibacterial drug levofloxacin with lipid bilayers of various compositions: 100% DPPC and with the addition of 20% cardiolipin. For DPPC liposomes, levofloxacin was found to penetrate into the subpola...
Synthesis, Antiviral, and Antibacterial Activity of the Glycyrrhizic Acid and Glycyrrhetinic Acid Derivatives [0.03%]
甘草亭酸和甘草次酸衍生物的合成及其抗病毒和抗菌活性研究
E A H Mohammed,Y Peng,Z Wang et al.
E A H Mohammed et al.
Glycyrrhizic acid and its primary metabolite glycyrrhetinic acid, are the main active ingredients in the licorice roots (glycyrrhiza species), which are widely used in several countries of the world, especially in east asian countries (Chin...
Design, Synthesis, and Molecular Docking Studies of Some New Quinoxaline Derivatives as EGFR Targeting Agents [0.03%]
作为EGFR靶向剂的一些新的喹唑啉衍生物的设计、合成及分子对接研究
Vinitha Badithapuram,Satheesh Kumar Nukala,Narasimha Swamy Thirukovela et al.
Vinitha Badithapuram et al.
The synthesis of some new quinoxaline derivatives (IVa-n) and their structure determination using 1H NMR, 13C NMR and mass spectral analysis was described herein. The in vitro anti-cancer activity of the these compounds (IVa-n) revealed tha...
Methods to Produce Monoclonal Antibodies for the Prevention and Treatment of Viral Infections [0.03%]
用于防治病毒感染的单克隆抗体生产方法
Yu A Merkuleva,D N Shcherbakov,A A Ilyichev
Yu A Merkuleva
A viral threat can arise suddenly and quickly turn into a major epidemic or pandemic. In such a case, it is necessary to develop effective means of therapy and prevention in a short time. Vaccine development takes decades, and the use of an...
Identification of Some Promising Heterocycles Useful in Treatment of Allergic Rhinitis: Virtual Screening, Pharmacophore Mapping, Molecular Docking, and Molecular Dynamics [0.03%]
用于治疗过敏性鼻炎的异环类药物虚拟筛选、药效团单元映射、分子对接及动力学模拟研究某些有前景的杂环化合物
Xiaopeng Sun,Amany Belal,Mohamed A Elanany et al.
Xiaopeng Sun et al.
Rhinitis is an allergic disease that causes troubles and restlessness for patients. In this research work we will focus on finding promising organic molecules with potential ability to target histamine receptor with no sedative side effect....
Rolling Circle Amplification as a Universal Method for the Analysis of a Wide Range of Biological Targets [0.03%]
滚圈扩增技术成为分析多种生物靶标的通用方法
R R Garafutdinov,A R Sakhabutdinova,A R Gilvanov et al.
R R Garafutdinov et al.
Detection and quantification of biotargets are important analytical tasks, which are solved using a wide range of various methods. In recent years, methods based on the isothermal amplification of nucleic acids (NAs) have been extensively d...
Azaadamantanes, a New Promising Scaffold for Medical Chemistry [0.03%]
一种新的用于药物化学的很有前景的骨架结构亚艾萨钻烷类化合物
E V Suslov,K Yu Ponomarev,K P Volcho et al.
E V Suslov et al.
Azaadamantanes are nitrogen-containing analogs of adamantane, which contain one or more nitrogen atoms instead of carbon atoms. This substitution leads to several specific chemical and physical properties. The azaadamantane derivatives have...
Natural Products as Potential Antiviral Drugs: The Specific Case of Marine Biotoxins [0.03%]
天然产物作为潜在的抗病毒药物：海洋生物毒素的具体案例分析
Jean-Louis Kraus
Jean-Louis Kraus
To fight against various viral infections researchers turned to new chemical structures resulting from natural medicinal plants and more recently from "marine origin" as sources of active molecules against viral infections. The present manu...
Zahraa Talib Khudhair,Mehdi Salih Shihab,Baram Hamah-Ameen
Zahraa Talib Khudhair
The drug development process for Coronavirus disease (COVID-19) is the research process to create a preventive vaccine or therapeutic prescription drug to relieve the severity of 2019-2020 (COVID-19). In different stages of preclinical or c...
V A Brylev,I L Lysenko,E A Kokin et al.
V A Brylev et al.
An azido-derivative of a fluorescein bifluorophore was obtained and used for the synthesis of "molecular beacon"-type oligonucleotide fluorogenic probes for RT-PCR. Eight probe variants were synthesized based on an optimized sequence: with ...