Cardioprotective effect of natural products on doxorubicin-induced cardiotoxicity and cardiac ischemia-reperfusion injury: A focus on ion channels modulation [0.03%]
天然产物对多柔比星致心肌毒性和心脏缺血再灌注损伤的保护作用：以离子通道调节为中心的研究焦点
Lucas Andrade De Sá,Lorrane Nere De Lima,Douglas Costa Andrade et al.
Lucas Andrade De Sá et al.
This article reviews the cardioprotective effects of natural products against doxorubicin (DOX)-induced cardiotoxicity and ischemia-reperfusion (I/R) injury, focusing on the modulation of ion channels and oxidative stress. Both conditions s...
Letícia Expedita Alves Dantas,Joana Menezes da Cunha Farias,Igor Guimarães Honorato et al.
Letícia Expedita Alves Dantas et al.
Breast cancer is the leading form of cancer in women worldwide. Despite extensive research efforts to develop detection methods and treatment, mortality remains high. Biomarkers and therapeutic targets are needed. Tumoral cell express ion c...
Possible therapeutic effects of essential oils on voltage dependent Na+ channels in experimental diabetic neuropathy [0.03%]
实验性糖尿病神经病变中精油对电压门控钠通道可能的治疗作用
Francisco Walber Ferreira-da-Silva,Romário Pinheiro-Lustosa,Francisca Edilziane Rodrigues-da-Silva et al.
Francisco Walber Ferreira-da-Silva et al.
Diabetic neuropathy (DN) is the most frequent complication of diabetes mellitus (DM), characterized by derangements of somatic and autonomic nerves, predominantly the longest nerves. DN is clinically relevant because it may seriously damage...
Nerve electrophysiological alterations in experimental diabetic neuropathy [0.03%]
实验性糖尿病神经病变的神经电生理学改变
Kerly Shamyra da Silva-Alves,Francisco Walber Ferreira-da-Silva,Bianca de Sousa Barbosa-Ferreira et al.
Kerly Shamyra da Silva-Alves et al.
Peripheral diabetic neuropathy (PDN) is a complication of diabetes mellitus that affects nerves and has great epidemiological and clinical relevance. It affects more than 2/3 of diabetic patients, compromising their quality of life and life...
Pathophysiological insights into ion channel dysregulation and electrical remodeling in cardiac cells during Trypanosoma cruzi infection [0.03%]
条血虫感染过程中心脏细胞离子通道失调及电重构的病理生理学见解
Ivan Lobo de Sousa Marques,Mario Henrique Veiga Meireles,Julliane Vasconcelos Joviano-Santos et al.
Ivan Lobo de Sousa Marques et al.
Chagas disease (CD), caused by Trypanosoma cruzi, affects 6-7 million people globally. Its most severe form, chagasic cardiomyopathy (CCM), develops in ∼30 % of infected individuals after a long latency and is highly lethal, with sudden ca...
Thyroid hormone deficiency-induced cardiac ion channel dysfunction: Molecular mechanisms and arrhythmic implications [0.03%]
甲状腺激素缺乏诱导的心脏离子通道功能障碍：分子机制和心律失常意义
Luiz Fernando Santos Matos,Emanuel Barbosa Dos Santos,Camila Souza Gama Rocha et al.
Luiz Fernando Santos Matos et al.
Thyroid hormones are essential regulators of cardiac excitability, contractility, and rhythm. Hypothyroidism induces profound electrophysiological remodeling through both genomic and non-genomic pathways, leading to altered expression and f...
Chemically induced cardiotoxicity: Role of voltage dependent ion channels [0.03%]
化学诱导的心脏毒性：电压门控离子通道的作用
Diego Jose Belato Orts,Aimée Obolari Durço,Michael Ramon de Lima Conceição et al.
Diego Jose Belato Orts et al.
Chemicals pervade human environments, with> 350,000 synthetic compounds driving unintentional exposures and pollution-linked deaths exceeding those from infectious diseases or violence. This review discusses the mechanisms of chemically ind...
ATP-sensitive potassium channels in neurons: Roles in and beyond metabolic control [0.03%]
神经元中的ATP敏感型钾通道：作用不止于代谢控制
Ricardo Maurício Leão,Mariane Martins Migliaccio,Daniela Ferreira de Siqueira et al.
Ricardo Maurício Leão et al.
ATP-sensitive potassium (KATP) channels are part of the inwardly rectifying potassium (Kir) channel family and are distinguished by their inhibition by intracellular ATP. Their role in pancreatic β-cells is well understood: increases in AT...