Preface [0.03%]
Pathophysiological insights into ion channel dysregulation and electrical remodeling in cardiac cells during Trypanosoma cruzi infection [0.03%]
Ivan Lobo de Sousa Marques,Mario Henrique Veiga Meireles,Julliane Vasconcelos Joviano-Santos et al.
Ivan Lobo de Sousa Marques et al.
Chagas disease (CD), caused by Trypanosoma cruzi, affects 6-7 million people globally. Its most severe form, chagasic cardiomyopathy (CCM), develops in ∼30 % of infected individuals after a long latency and is highly lethal, with sudden ca...
Thyroid hormone deficiency-induced cardiac ion channel dysfunction: Molecular mechanisms and arrhythmic implications [0.03%]
Luiz Fernando Santos Matos,Emanuel Barbosa Dos Santos,Camila Souza Gama Rocha et al.
Luiz Fernando Santos Matos et al.
Thyroid hormones are essential regulators of cardiac excitability, contractility, and rhythm. Hypothyroidism induces profound electrophysiological remodeling through both genomic and non-genomic pathways, leading to altered expression and f...
Diego Jose Belato Orts,Aimée Obolari Durço,Michael Ramon de Lima Conceição et al.
Diego Jose Belato Orts et al.
Chemicals pervade human environments, with> 350,000 synthetic compounds driving unintentional exposures and pollution-linked deaths exceeding those from infectious diseases or violence. This review discusses the mechanisms of chemically ind...
Ricardo Maurício Leão,Mariane Martins Migliaccio,Daniela Ferreira de Siqueira et al.
Ricardo Maurício Leão et al.
ATP-sensitive potassium (KATP) channels are part of the inwardly rectifying potassium (Kir) channel family and are distinguished by their inhibition by intracellular ATP. Their role in pancreatic β-cells is well understood: increases in AT...
Fungal extracellular vesicles: Advances and perspectives in treatments, therapies, and vaccination [0.03%]
菌丝细胞外囊泡：治疗、疗法和疫苗方面的进展与前景
Karen Spadari Ferreira,Sarah Fernandes Lima,Larissa Dos Santos Duarte et al.
Karen Spadari Ferreira et al.
Extracellular vesicles (EVs) are membrane-bound nanostructures secreted by various cell types under physiological and pathological conditions. These vesicles carry a diverse cargo of biologically active molecules, including proteins, lipids...
Cross-species immunomodulation by zoonotic helminths: The roles of excretory/secretory products and extracellular vesicles [0.03%]
人畜共患蠕虫的跨物种免疫调节作用：排泄分泌产物和细胞外囊泡的作用机制
Marilyn Zumbado-Salas,Alicia Rojas,Rick M Maizels et al.
Marilyn Zumbado-Salas et al.
Parasitic helminths display remarkable plasticity in their interactions with the host immune system. Zoonotic species can elicit markedly different immune profiles depending on the host, ranging from balanced responses that allow long-term ...
Juliana Fortes,Gabriela Villa Marin,Náthani Negreiros et al.
Juliana Fortes et al.
Viruses are subcellular structures that depend on the host cell to replicate, sharing several characteristics with extracellular vesicles (EVs). EVs act in intercellular communication and the regulation of the immune system and can be explo...
Marina Malheiros Araújo Silvestrini,Fábio Magalhães-Gama,Andréa Teixeira-Carvalho
Marina Malheiros Araújo Silvestrini
Extracellular vesicles (EVs) have emerged as key mediators in cancer biology, playing critical roles in intercellular communication within the tumor microenvironment. These nano-sized particles carry diverse molecular cargos, including prot...