Tohru Morisada,Yoshiaki Kubota,Takashi Urano et al.
Tohru Morisada et al.
Vascular network formation requires several endothelial cell growth factors. These factors have a potent angiogenic effect, and their precise coordination is essential for vascular development. Among them, angiopoietins function through the...
Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E [0.03%]
血管内皮生长因子(VEGF)受体2：其生物学功能、主要信号通路和特异性配体VEGF-E
Masabumi Shibuya
Masabumi Shibuya
Two high-affinity receptors for vascular endothelial growth factor (VEGF)-A, VEGFR1 and VEGFR2, cooperate for physiological vasculogenesis and angiogenesis in embryogenesis. VEGFR2 transduces the major signals for angiogenesis via its stron...
Sphingosine-1-phosphate-induced intracellular Ca2+ mobilization in human endothelial cells [0.03%]
鞘氨醇-1-磷酸盐使人类内皮细胞内的Ca2+活化
Geun Hee Seol,Moon Young Kim,Guo Hua Liang et al.
Geun Hee Seol et al.
The authors have studied the effect of sphingosine-1-phosphate (S1P) on Ca2+ release from intracellular stores in cultured human umbilical vein endothelial cells (HUVECs). In the presence of extracellular Ca2+, S1P increased intracellular C...
Vladimir Mironov,Richard P Visconti,Roger R Markwald
Vladimir Mironov
The relative contribution of physical and chemical factors in organogenesis in general and in cardiogenesis in particular is an old and still unsolved question in developmental biology (Chang 1932, Anatomical Record, 51, 253-265). A recent ...
Endostatin down-regulates soluble guanylate cyclase (sGC) in endothelial cells in vivo: influence of endostatin on vascular endothelial growth factor (VEGF) signaling [0.03%]
内皮细胞中内皮抑素下调可溶性鸟苷酸环化酶(sGC): 内皮抑素对血管内皮生长因子(VEGF)信号传导的影响
Annette Schmidt,Daniela Wenzel,Irmgard Thorey et al.
Annette Schmidt et al.
Endostatin was suggested to be an antiangiogenic agent with the potential for clinical use in cancer therapy. Unfortunately, up to now no antiangiogenic effect was seen in clinical trials using this substance. The lack of response might be ...
Endothelial progenitor cells and their potential clinical applications in peripheral arterial disease [0.03%]
内皮祖细胞及其在周围动脉疾病中的潜在临床应用
N Alobaid,M E Alnaeb,K M Sales et al.
N Alobaid et al.
Endothelial progenitor cells (EPCs) were originally thought to be present only during embryonic development. New evidence suggests that they can persist into adult life, circulate in the peripheral blood and may play an important part in en...
Atorvastatin affects several angiogenic mediators in human endothelial cells [0.03%]
阿托伐他汀影响人的内皮细胞中的几种促血管生成介导物
Józef Dulak,Agnieszka Loboda,Agnieszka Jazwa et al.
Józef Dulak et al.
The pleiotropic effects of statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, have been recently extended to the modulation of angiogenesis. Here, to get more insight into the statins action, the authors have ...
Effect of systemic insulin and angiotensin II receptor subtype-1 antagonist on endothelin-1 receptor subtype(s) regulation and binding in diabetic rat heart [0.03%]
胰岛素和血管紧张素II受体拮抗剂对糖尿病大鼠心脏内皮素-1受体亚型调节及结合的影响
Chehade N Karam,Nuha Nuwayri-Salti,Julnar A Usta et al.
Chehade N Karam et al.
This study reports on the regulation and remodeling role of endothelin-1 (ET-1) and its receptor subtypes, ET(A)-Rs/ET(B)-Rs, at the coronary endothelium (CE) and cardiomyocyte (CM) sites. It is carried out in normal and normotensive rats w...
Methodological studies of multiple reference genes as endogenous controls in vascular gene expression studies [0.03%]
血管基因表达研究中同时使用多个内参基因的方法学研究
R Doroudi,M Andersson,P-A Svensson et al.
R Doroudi et al.
Detection and quantification of differentially expressed genes requires valid and reliable references to control for error variability introduced by preparatory procedures or efficiency of reverse transcription and polymerase chain reaction...
Endothelial biomedicine: its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap [0.03%]
血管生物医学：作为交叉学科的地位、作为基础科学的进步及其转化研究的实验室到临床的应用差距
Charlotte Hwa,Anthony Sebastian,William C Aird
Charlotte Hwa
The endothelium, a layer of endothelial cells lining the luminal surface of all blood vessels, functions as a highly metabolically active organ spatially distributed throughout the body. Despite enormous advances in our understanding of end...