Contrasting effects of phosphatidylinositol- and phosphatidylcholine-specific phospholipase C on apoptosis in cultured endothelial cells [0.03%]
磷脂酶C特异性作用于磷脂idyinositol和磷脂idylcholine对培养内皮细胞凋亡的相反效应
Xia Liu,Qitao Zhao,Satohiko Araki et al.
Xia Liu et al.
In the authors' previous studies, they found that phosphatidylcholine-specific phospholipase C (PC-PLC) and phosphatidylinositol-specific phospholipase C (PI-PLC) played contrary roles in the apoptosis of vascular endothelial cells (VECs), ...
Heterogeneity of capillary endothelial cells for basic fibroblast growth factor-induced paracrine signaling [0.03%]
内皮细胞异质性介导的碱性成纤维细胞生长因子旁分泌信号作用
Tae-Hee Lee,Hyung-Chahn Lee,Young Sook Son et al.
Tae-Hee Lee et al.
In this study, the authors isolated morphologically different capillary endothelial cells, designated as BCE-1 and BCE-2 cells, from bovine adrenal cortex. By a series of experiments involving proliferation, migration, and tubular-like stru...
Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium [0.03%]
罗格列酮拮抗心脏瓣膜内皮细胞的血管内皮生长因子信号转导和活化T细胞核因子的激活
Tara L Sander,LeAnne Noll,Denise B Klinkner et al.
Tara L Sander et al.
Nuclear factor of activated T cells, Cytoplasmic 1 (NFATc1) is required for heart valve formation. Vascular endothelial growth factor (VEGF) signaling, mediated by NFATc1 activation, positively regulates growth of valvular endothelial cells...
Shear stress protects against endothelial regulation of vascular smooth muscle cell migration in a coculture system [0.03%]
剪切应力通过内皮细胞调节血管平滑肌细胞迁移的作用机制的研究
Han Qin Wang,Lang Xian Huang,Ming Juan Qu et al.
Han Qin Wang et al.
Vascular endothelial cells (ECs) are constantly exposed to blood flow-induced shear stress; these forces strongly influence the behaviors of neighboring vascular smooth muscle cells (VSMCs). VSMC migration is a key event in vascular wall re...
Active stress kinases in proliferating endothelial cells associated with cytoskeletal structures [0.03%]
与细胞骨架结构相关的增殖性内皮细胞活性应力蛋白激酶
Marianne Hamel,Daniela Kanyi,Mark D Cipolle et al.
Marianne Hamel et al.
It has become increasingly clear that stress-activated protein kinases have cytoplasmic substrates in addition to well-established transcription factor substrates in cell nuclei. The present study documented specific cytoplasmic locations o...
Yasufumi Sato
Yasufumi Sato
Angiogenesis is regulated by a local balance between the levels of endogenous stimulators and inhibitors of angiogenesis. Understanding of the mechanism of angiogenesis has advanced significantly since the discovery of two members of the fa...
Differentiation of arterial and venous endothelial cells and vascular morphogenesis [0.03%]
动脉内皮细胞和静脉内皮细胞的分化以及血管发生
Masanori Hirashima,Toshio Suda
Masanori Hirashima
The vascular system is comprised of an organized hierarchical structure of arteries, veins, and capillaries. Recent studies in zebrafish, chick, and mouse reveal that the identity of artery and vein is governed by genetic factors as well as...
Vascular integrins in tumor angiogenesis: mediators and therapeutic targets [0.03%]
肿瘤血管生成中的血管整合素：介导物和治疗靶点
Gian Carlo Alghisi,Curzio Rüegg
Gian Carlo Alghisi
The notion that tumor angiogenesis may have therapeutic implications in the control of tumor growth was introduced by Dr. Judah Folkman in 1971. The approval of Avastin in 2004 as the first antiangiogenic systemic drug to treat cancer patie...
Extracellular angiogenic growth factor interactions: an angiogenesis interactome survey [0.03%]
细胞外血管生成生长因子互作：血管生成互作组研究综述
Marco Rusnati,Marco Presta
Marco Rusnati
Angiogenesis plays a key role in various physiological and pathological processes, including inflammation and tumor growth. Numerous angiogenic growth factors (AGFs) have been identified. Usually, the angiogenic process is assumed to repres...
Federico Bussolino,Donatella Valdembri,Francesca Caccavari et al.
Federico Bussolino et al.
In vertebrate embryos, development of an architecturally optimized blood vessel network allows the efficient transport of oxygen and nutrients to all other tissues. The final shape of the vascular system results from vasculogenesis and angi...