Fluorescent cyclopropyl ester probes are efficiently cleaved by endogenous carboxylesterase in mouse blood: implications for preclinical fluorescence imaging [0.03%]
荧光环丙基酯探针可被小鼠血液中的内源性羧酸酯酶有效裂解：对临床前荧光成像的意义
Hailey S Sanders,Kirk M Atkinson,Bradley D Smith
Hailey S Sanders
Prior studies have shown that fluorescent molecular probes based on cyclopropyl esters are good substrates for butyrylcholinesterase (BChE) which is a biomarker of several human diseases. We tested two fluorescent cyclopropyl ester derivati...
Corinne L D Gibb,André J Hebert,Yahya A Ismaiel et al.
Corinne L D Gibb et al.
Octa-acid 1 is a water-soluble deep-cavity cavitand devised in our labs that has found utility in a number of research groups. The host has been used to investigate hydrophobic solvation and Hofmeister effects, control photophysical and phy...
NASC 2023: Showcasing Diversity in North American Supramolecular Chemistry [0.03%]
2023年北美超分子化学的多样性：NASC会议展示
Nathalie Busschaert,Clifton J Stephenson,Kristin Bowman-James et al.
Nathalie Busschaert et al.
Diversity in supramolecular chemistry can showcase itself in many ways. This includes the diversity of thought and topics covered in research (from fundamental science to applications in biology and materials), as well as the diversity of p...
Dynamic Light Scattering - an all-purpose guide for the supramolecular chemist [0.03%]
动态光散射-超分子化学家的全方位指南
Anthony Wishard,Bruce C Gibb
Anthony Wishard
Dynamic light scattering (DLS) is a useful tool for the study of the solution-based behavior of colloids and molecular assemblies. The aim of this methods paper is to provide perspective on how this technique can be used by supramolecular c...
Kimberly G Brady,Bingqing Liu,Xiaopeng Li et al.
Kimberly G Brady et al.
We report preparation of (bis)aniline ligand 4 which contains a central viologen binding domain and its subcomponent self-assembly with aldehyde 5 and Fe(OTf)2 in CH3CN to yield tetrahedral assembly 6. Complexation of ligand 4 with CB[7] in...
Ming Cheng,Lyle Isaacs
Ming Cheng
We report the design and synthesis of the acyclic cucurbit[n]uril-β-cyclodextrin chimeric host H1. The goal of the study is to deepen the cavity of the receptor to allow β-CD complexation of moieties on the guest (especially fentanyl) tha...
Eman A Akam,Ritika Gautam,Elisa Tomat
Eman A Akam
Sirtinol, a Schiff base derived from 2-hydroxy-1-naphthaldehyde, is an inhibitor of sirtuin proteins, a family of deacetylases active in gene regulation and relevant to the study of cancer growth. The formation of copper(II) and zinc(II) co...
Nicholas B Wageling,Daniel A Decato,Orion B Berryman
Nicholas B Wageling
The study of hydrogen bonding organocatalysis is rapidly expanding. Much research has been directed at making catalysts more active and selective, with less attention on fundamental design strategies. This study systematically increases ste...
Self-assembly of emissive metallocycles with tetraphenylethylene, BODIPY and terpyridine in one system [0.03%]
基于四苯乙烷、BODIPY和联吡啶的一类发射型金属大环的自组装研究
Yu Yan,Guang-Qiang Yin,Sandra Khalife et al.
Yu Yan et al.
Tetraphenylethylene (TPE) related (supra)molecules have been intensively investigated due to their aggregation-induced emission (AIE) effect based on the restriction of intramolecular rotation (RIR). Meanwhile, boron-dipyrromethene (BODIPY)...
Conformationally Mobile Acyclic Cucurbit[n]uril-Type Receptors Derived from an S-shaped Methylene Bridged Glycoluril Pentamer [0.03%]
一种S型亚甲基桥连的甘油尿素五聚体的构象移动的无环 cucurbit[n] 尿素型受体
Kimberly G Brady,Laura Gilberg,David Sigwalt et al.
Kimberly G Brady et al.
We report the synthesis of the conformationally mobile S-shaped glycoluril pentamer building block 3a and two new acyclic CB[n]-type receptors P1 and P2. P1 (9 mM) and P2 (11 mM) have moderate aqueous solubility but their host•guest comple...