Histologic, viral, and molecular correlates of dengue fever infection of the liver using highly sensitive immunohistochemistry [0.03%]
基于高敏感度免疫组化的肝组织、病毒和分子水平登革热感染的检测及相关性分析
Fabiane Carvalho de Macedo,Alcina F Nicol,Lynn D Cooper et al.
Fabiane Carvalho de Macedo et al.
The mechanism by which the virus associated with dengue fever can cause a fatal hepatitis is not well understood. The purpose of this study was to examine 9 cases of fatal dengue hemorrhagic fever-associated hepatitis, and to correlate the ...
Chromosomal and microsatellite instability of adenocarcinomas and dysplastic lesions (DALM) in ulcerative colitis [0.03%]
溃疡性结肠炎腺癌和不典型增生的染色体及微卫星不稳定性的研究
Jolanda M van Dieren,Josiane C Wink,Kees J Vissers et al.
Jolanda M van Dieren et al.
Longstanding ulcerative colitis (UC) is associated with a high risk of developing UC-related colonic adenocarcinoma (UCC). These carcinomas originate from nonadenomatous dysplastic regions referred to as dysplasia associated lesion or mass ...
Pattern and distribution of immunoglobulin VH gene usage in a cohort of B-CLL patients from a Northeastern region of Italy [0.03%]
意大利东北部一例B细胞慢性淋巴细胞白血病患者的免疫球蛋白VH基因使用模式和分布状况分析
Pietro Maria Donisi,Nadia Di Lorenzo,Manuela Riccardi et al.
Pietro Maria Donisi et al.
We analyzed individual VH gene rearrangements in 55 consecutive B-chronic lymphocytic leukemia (B-CLL) patients collected from a northeastern region of Italy, stressing the possible differences related to geographic characteristics of the c...
Microarray analysis of MRI-defined tissue samples in glioblastoma reveals differences in regional expression of therapeutic targets [0.03%]
胶质母细胞瘤的微阵列分析显示治疗目标的区域表达差异
Timothy Van Meter,Catherine Dumur,Naiel Hafez et al.
Timothy Van Meter et al.
Microarray technologies have come into prominence for the assessment of molecular diagnostic profiles in cancer tissue biopsies. To better understand the effect of sampling bias, we paired image-guided stereotactic biopsy and microarray tec...
Yahya I Elshimali,Wayne W Grody
Yahya I Elshimali
Tumors launch malignant cells into the circulation continuously. In early stages, the immune surveillance system eliminates these cells from the circulation, but at later times they may persist longer and be detected. The first recorded evi...
Simple and effective determination of apolipoprotein E genotypes by positive/negative polymerase chain reaction products [0.03%]
通过正负聚合酶链反应产物简单而有效地确定载脂蛋白E基因型
Davide Seripa,Emanuela Signori,Carolina Gravina et al.
Davide Seripa et al.
Several protein and DNA-based methods have been previously described for the identification of apolipoprotein E isoforms or genotypes. However, all of them generate frequently false-positive results. The purpose of this study was to set up ...
Seminested polymerase chain reaction (PCR) for detecting Helicobacter pylori DNA in carotid atheromas [0.03%]
半嵌套聚合酶链反应检测颈动脉粥样硬化斑块中幽门螺杆菌DNA
Eugenia Arias,Horacio Martinetto,Marcelo Schultz et al.
Eugenia Arias et al.
A polymerase chain reaction (PCR) method for the detection of the glmM gene, selected as Helicobacter pylori target sequence, was improved. While performing pathogenicity island cagA gene detection to discriminate pathogenic strains in athe...
Direct screening of clinical specimens for multiple respiratory pathogens using the Genaco Respiratory Panels 1 and 2 [0.03%]
采用Genaco呼吸道病原体检测 panel 1和panel 2对多种呼吸道病原体进行直接临床标本筛查
John Brunstein,Eva Thomas
John Brunstein
We report here on the results of a pilot study comparing our clinical diagnostic virology laboratory's current methods of respiratory pathogen detection against the Genaco Respiratory Infections Panels 1 and 2. These assays employ xMap (Lum...
Adequacy of colonoscopic biopsy specimens for molecular analysis: a comparative study with colectomy tissue [0.03%]
结肠镜活组织检查标本的分子分析充分性与结肠切除术组织的比较研究
Neil P Zauber,Marlene Sabbath-Solitare,Stephen Marotta et al.
Neil P Zauber et al.
Molecular analyses of tumors are increasingly useful for prognosis and for guiding therapy. Colonoscopic biopsy provides the first source of tissue for most cases of colorectal carcinoma and therefore might become an important source for mo...
Construction and validation of tissue microarrays of ductal carcinoma in situ and terminal duct lobular units associated with invasive breast carcinoma [0.03%]
乳腺导管原位癌及伴发浸润性乳腺癌的终末导管小叶单位组织芯片的制备与验证
Xiaohong Rose Yang,Lori A Charette,Montserrat Garcia-Closas et al.
Xiaohong Rose Yang et al.
Construction of tissue microarrays (TMAs) to efficiently characterize large sets of noninvasive epithelial lesions in the breast by immunohistochemistry is an appealing investigative approach, but presents technical challenges. We report me...