Diagnostic molecular pathology in an era of genomics and translational bioinformatics [0.03%]
基因组学和转化生物信息学时代的研究分子病理学诊断
Daniel H Farkas
Daniel H Farkas
Optimization of the Affymetrix GeneChip Mapping 10K 2.0 Assay for routine clinical use on formalin-fixed paraffin-embedded tissues [0.03%]
优化Affymetrix基因芯片映射10K 2.0检测流程，以在临床中常规应用于福尔马林固定的石蜡包埋组织样本
Maureen Lyons-Weiler,Jill Hagenkord,Christin Sciulli et al.
Maureen Lyons-Weiler et al.
The use of chromosomal copy number changes as markers for tumor behavior or as prognostic markers for patient outcome has been suggested. However, current clinically used technologies cannot perform genome-wide assessment of chromosome copy...
Detection of FOXO1 (FKHR) gene break-apart by fluorescence in situ hybridization in formalin-fixed, paraffin-embedded alveolar rhabdomyosarcomas and its clinicopathologic correlation [0.03%]
荧光原位杂交检测福尔马林固定石蜡包埋的肺泡横纹肌肉瘤中FOXO1（FKHR）基因断裂及其临床病理相关性
Shveta Mehra,Gustavo de la Roza,Jamie Tull et al.
Shveta Mehra et al.
Chromosomal translocations of t(2;13)(q35;q14) and t(1;13)(p36;q14), resulting in PAX3-FOXO1 (FKHR) and PAX7-FOXO1 (FKHR) gene fusions, have been found to be specific molecular markers for alveolar rhabdomyosarcomas (ARMS) and can be identi...
Viral detection and tumor necrosis factor alpha profile in tracheal aspirates from children with suspicion of myocarditis [0.03%]
疑似心肌炎儿童气管吸引物中的病毒检测和肿瘤坏死因子α谱型
Elisa Carturan,Ornella Milanesi,Yasuchica Kato et al.
Elisa Carturan et al.
Pediatric myocarditis is a serious disease resulting in significant morbidity and mortality. Tracheal aspirate (TA) has been demonstrated to be a sensitive diagnostic tool to detect viral agents responsible for respiratory disorders and myo...
Assessment of RT-PCR detection of human mammaglobin for the diagnosis of breast cancer derived pleural effusions [0.03%]
评估实时RT-PCR检测人乳腺特异性蛋白mammaglobin在诊断癌性胸腔积液中的价值
Silvio Roncella,Paola Ferro,Bartolomeo Bacigalupo et al.
Silvio Roncella et al.
The present study investigates the diagnostic significance of human mammaglobin (hMAM) mRNA expression in pleural effusions (PE) from breast cancer (BC) patients. Two hundred and fifty PE samples, including 32 from patients who had diagnosi...
Quantification of free plasma DNA before and after chemotherapy in patients with advanced epithelial ovarian cancer [0.03%]
晚期上皮性卵巢癌患者化疗前后的血浆游离DNA量化研究
Elisa Capizzi,Elena Gabusi,Antonia D&#x;Errico Grigioni et al.
Elisa Capizzi et al.
Objectives: A nonrandomized trial was planned to investigate the role of free plasma DNA (FPDNA) in patients with epithelial ovarian cancer before and after chemotherapy. Twenty-two patients with advanced stage ovarian ca...
Quantitative measurement of cyclin D1 mRNA, a potent diagnostic tool to separate mantle cell lymphoma from other B-cell lymphoproliferative disorders [0.03%]
定量测量环胞素D1信使核糖核酸，一种将套细胞淋巴瘤与其他B细胞淋巴增生性疾病区分的强有力的诊断工具
Helena Brizova,Marketa Kalinova,Lenka Krskova et al.
Helena Brizova et al.
Cyclin D1 overexpression as a result of t(11;14) is a specific marker for diagnosis of mantle cell lymphoma (MCL) and plays an important role in MCL pathogenesis. To set a highly reliable cutoff value that discriminates MCL from other B-cel...
Effects of processing delay, formalin fixation, and immunohistochemistry on RNA Recovery From Formalin-fixed Paraffin-embedded Tissue Sections [0.03%]
处理延迟、福尔马林固定和免疫组化对从石蜡包埋切片中回收RNA的影响
Febe van Maldegem,Mireille de Wit,Folkert Morsink et al.
Febe van Maldegem et al.
Contemporary pathology involves an emerging role for molecular diagnostics. Current tissue handling procedures [ie, formalin fixation and paraffin embedment (FFPE)] have their origin in the aim to obtain good tissue morphology and optimal r...
Looking for ferns: optimization of digestion pretreatment in fluorescence in situ hybridization (FISH) technique on paraffin-embedded tissues [0.03%]
寻找蕨类植物：优化荧光原位杂交（FISH）技术中石蜡包埋组织消化前处理的方法
Marta Tojo,Raquel Perez-Becerra,Angel Vazquez-Boquete et al.
Marta Tojo et al.
Fluorescence in situ hybridization (FISH) is a useful cytogenetic technique for the detection of chromosome aberrations. However, applying this technique routinely on paraffin-embedded tissue is hampered by technical problems. The efficienc...
Malignant ectomesenchymoma: genetic profile reflects rhabdomyosarcomatous differentiation [0.03%]
恶性外胚层肿瘤的遗传特性体现横纹肌肉瘤分化特点
Giuseppe Floris,Maria Debiec-Rychter,Agnieszka Wozniak et al.
Giuseppe Floris et al.
Malignant ectomesenchymoma (MEM) represents a heterogeneous group of tumors, most likely originating from pluripotent primitive neural crest cells. In this report, we present an 8-month-old infant boy with an MEM on the left scrotum. Retros...